Insect Immune-Related Genes and Gene Families

A simple access point to view gene family assignments, annotations and phylogenetic data.
To access the archived version of the ImmunoDB resource released with the publication, “Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes”, Science, 2007, please click here.
This updated ImmunoDB resource includes data on additional immune-related gene families and more insect species.

Keyword Search:

View expert annotations for D. melanogaster, A. gambiae, A. aegypti and C. quinquefasciatus
Select a Family:
Select a Species:
The predicted gene models have been examined for each gene family to improve the annotations and build accurate multiple sequence alignments from which to estimate evolutionary relationships among the genes in each of the three mosquito species and the fruitfly.

Search for Orthologous Groups of Immune-Related Genes From 23 Arthropod Species
Select a Family:
Select a Search Level:
Employing characteristic protein domains (InterPro) and keyword annotations, the catalogue of arthropod orthologues can be searched at different levels of the species phylogeny to identify immune-related genes in additional species to the four above for which expert annotations are available. NB: when using this search feature, please bear in mind that these are automatic gene predictions that have not been manually curated and the orthologous groups are unlikely to encompass all homologous genes in any given species.

Citing ImmunoDB: Waterhouse et al, Science, 2007, Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes PMID:17588928
Download Original Research Article: pdf    Download Online Supporting Material: pdf
Please visit the support page for further details on methods employed and tips on viewing and manipulating multiple sequence alignments and phylogenetic trees.
Please note, these data represent comprehensive manual efforts to check and correct automatic gene predictions followed by building of alignments and phylogenetic trees. Please contact RMW with any comments, suggestions, or corrections.

Contacts: robert.waterhouse [at] Robert M Waterhouse
  evgenia.kriventseva [at] Evgenia V Kriventseva
  g.christophides [at] George K Christophides
  evgeny.zdobnov [at] Evgeny M Zdobnov
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