Welcome

We focus on comparative analyses of genome sequences to understand principles of molecular evolution and approach the fundamental questions of the origin and evolution of biological complexity. Through analysis of multiple species, we aim to quantify evolutionary processes that shape repertoires of functional genomic elements such as
  • protein coding genes
  • non-coding RNA genes (e.g. microRNAs), and
  • conserved non-genic sequences (CNS)
as well as to interrogate and predict their functions, analysing sequence variability patterns among different species and within populations. Prioritising medical and evolutionary questions, we are focusing on two strategic directions of vertebrate and insect genomics, where we are participating in international collaborative projects to analyze new genomes and collaborating with experimental functional genomics laboratories.
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rhinovir2

Genomics and Pathogenomics of the Culex Mosquito

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Selected recent publications

Social insect genomes: dramatic evolution in gene composition & regulation, preserving regulatory features linked to sociality

Simola DF, Wissler L, Donahue G, Waterhouse RM, Helmkampf M, Roux J, Nygaard S, Glastad K, Hagen DE, Viljakainen L, Reese JT, Hunt BG, Graur D, Elhaik E, Kriventseva E, Wen J, Parker BJ, Cash E, Privman E, Childers CP, Munos-Torres MC, Boomsma JJ, Bornberg-Bauer E, Currie C, Elsik CG, Suen G, Goodisman MA, Keller L, Liebig J, Rawls A, Reinberg D, Smith CD, Smith CR, Tsutsui N, Wurm Y, Zdobnov EM, Berger SL, Gadau J.
Genome Research
PMID: 23636946

Identification of Site-Specific Adaptations Conferring Increased Neural Cell Tropism during Human Enterovirus 71 Infection.

Cordey S, Petty TJ, Schibler M, Martinez Y, Gerlach D, van Belle S, Turin L, Zdobnov EM, Kaiser L, Tapparel C.
PLoS Pathog
PMID: 22910880

The ecoresponsive genome of Daphnia pulex

Colbourne JK, Pfrender ME, Gilbert D, Thomas WK, Tucker A, Oakley TH, Tokishita S, Aerts A, Arnold GJ, Basu MK, Bauer DJ, Cáceres CE, Carmel L, Casola C, Choi JH, Detter JC, Dong Q, Dusheyko S, Eads BD, Fröhlich T, Geiler-Samerotte KA, Gerlach D, Hatcher P, Jogdeo S, Krijgsveld J, Kriventseva EV, Kültz D, Laforsch C, Lindquist E, Lopez J, Manak JR, Muller J, Pangilinan J, Patwardhan RP, Pitluck S, Pritham EJ, Rechtsteiner A, Rho M, Rogozin IB, Sakarya O, Salamov A, Schaack S, Shapiro H, Shiga Y, Skalitzky C, Smith Z, Souvorov A, Sung W, Tang Z, Tsuchiya D, Tu H, Vos H, Wang M, Wolf YI, Yamagata H, Yamada T, Ye Y, Shaw JR, Andrews J, Crease TJ, Tang H, Lucas SM, Robertson HM, Bork P, Koonin EV, Zdobnov EM, Grigoriev IV, Lynch M, Boore JL.
Science
PMID: 21292972

Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle

Kirkness EF, Haas BJ, Sun W, Braig HR, Perotti MA, Clark JM, Lee SH, Robertson HM, Kennedy RC, Elhaik E, Gerlach D, Kriventseva EV, Elsik CG, Graur D, Hill CA, Veenstra JA, Walenz B, Tubío JM, Ribeiro JM, Rozas J, Johnston JS, Reese JT, Popadic A, Tojo M, Raoult D, Reed DL, Tomoyasu Y, Krause E, Mittapalli O, Margam VM, Li HM, Meyer JM, Johnson RM, Romero-Severson J, Vanzee JP, Alvarez-Ponce D, Vieira FG, Aguadé M, Guirao-Rico S, Anzola JM, Yoon KS, Strycharz JP, Unger MF, Christley S, Lobo NF, Seufferheld MJ, Wang N, Dasch GA, Struchiner CJ, Madey G, Hannick LI, Bidwell S, Joardar V, Caler E, Shao R, Barker SC, Cameron S, Bruggner RV, Regier A, Johnson J, Viswanathan L, Utterback TR, Sutton GG, Lawson D, Waterhouse RM, Venter JC, Strausberg RL, Berenbaum MR, Collins FH, Zdobnov EM, Pittendrigh BR
Proc Natl Acad Sci U S A. 2010 Jun 21. [Epub ahead of print]
PMID: 20566863

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species

The Nasonia Genome Working Group (incl. Junier T, Gerlach D, Waterhouse RM, Kriventseva EV, Wyder S, Zdobnov EM)
Science. 2010 Jan 15;327(5963):343-8.
PMID: 20075255

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

The Bovine Genome Sequencing and Analysis Consortium (incl. Gerlach D, Junier T, Kriventseva EV, Zdobnov EM)
Science. 2009 Apr 24;324(5926):522-528
PMID: 19390049