Protein Design: Tailoring Sequence, Structure, and Folding Properties
Protein design algorithms identify protein sequences consistent with a particular fold, and often simultaneously quantify the many subtle, non-covalent interactions that govern protein folding, stability and function. Eﬀorts in protein design stand to advance our knowledge of protein folding and function and also can identify new proteins with applications to biotechnology, catalysis, and materials research. Here, recent developments in protein design are discussed with a focus on features common to many of the computational design methods. A sampling of studies is presented in which computationally designed proteins have been experimentally realized, exemplifying what may be learned and accomplished with protein design.
Victor Muñoz (Editor)