Top 500 InterPro hits

statistically significant differences are marked in bold (p-value of chi-square test < 0.01 without correction for multiple tests).

Aedes aegypti 15419 total genes ( 70% w domains)	Anopheles gambiae 13277 total genes ( 68% w domains)	Drosophila melanogaster 13450 total genes ( 67% w domains)	Apis mellifera 10157 total genes ( 70% w domains)	Family	GO terms
243 (4)	69 (32)	89 (17)	26 (61)	IPR012934: Zinc finger, AD-type
663 (1)	335 (1)	314 (1)	247 (1)	IPR007087: Zinc finger, C2H2-type	Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270)
168 (11)	40 (56)	86 (18)	47 (36)	IPR001128: Cytochrome P450	Molecular Function: monooxygenase activity (GO:0004497), Molecular Function: iron ion binding (GO:0005506), Biological Process: electron transport (GO:0006118), Molecular Function: heme binding (GO:0020037)
26 (108)	()	()	()	IPR000448: Rhabdovirus nucleocapsid protein	Cellular Component: viral nucleocapsid (GO:0019013)
41 (66)	6 (484)	3 (834)	4 (567)	IPR005055: Insect pheromone-binding protein A10/OS-D
191 (8)	98 (17)	89 (16)	69 (24)	IPR003656: Zinc finger, BED-type predicted	Molecular Function: DNA binding (GO:0003677)
47 (58)	11 (269)	6 (473)	7 (325)	IPR006612: Zinc finger, C2CH-type	Molecular Function: nucleic acid binding (GO:0003676)
233 (6)	128 (10)	100 (13)	31 (46)	IPR000618: Insect cuticle protein	Molecular Function: structural constituent of cuticle (GO:0042302)
499 (2)	325 (2)	()	()	IPR000694: Proline-rich region
24 (131)	3 (878)	4 (695)	2 (1155)	IPR007588: Zinc finger, FLYWCH-type
18 (193)	2 (1300)	4 (709)	6 (394)	IPR010629: Insect allergen related
24 (127)	44 (51)	17 (148)	17 (112)	IPR002126: Cadherin	Molecular Function: calcium ion binding (GO:0005509), Biological Process: homophilic cell adhesion (GO:0007156), Cellular Component: membrane (GO:0016020)
56 (49)	79 (25)	61 (33)	83 (15)	IPR004117: Olfactory receptor, Drosophila	Molecular Function: olfactory receptor activity (GO:0004984), Molecular Function: odorant binding (GO:0005549), Biological Process: perception of smell (GO:0007608), Cellular Component: membrane (GO:0016020)
27 (106)	8 (337)	17 (147)	8 (248)	IPR000637: HMG-I and HMG-Y, DNA-binding
30 (93)	11 (264)	18 (139)	4 (537)	IPR002656: Acyltransferase 3	Molecular Function: transferase activity, transferring groups other than amino-acyl groups (GO:0016747)
34 (80)	50 (44)	14 (205)	2 (953)	IPR002181: Fibrinogen, alpha/beta/gamma chain, C-terminal globular
31 (91)	12 (247)	22 (109)	4 (586)	IPR006693: AB-hydrolase associated lipase region	Biological Process: lipid metabolism (GO:0006629), Molecular Function: carboxylic ester hydrolase activity (GO:0016789)
128 (18)	79 (24)	81 (21)	38 (42)	IPR002557: Chitin binding Peritrophin-A	Cellular Component: extracellular region (GO:0005576), Biological Process: chitin metabolism (GO:0006030), Molecular Function: chitin binding (GO:0008061)
9 (367)	1 (1837)	1 (1833)	()	IPR005195: Glycoside hydrolase family 65, central catalytic
11 (314)	2 (1265)	3 (902)	5 (469)	IPR008273: Cellular retinaldehyde-binding/triple function, N-terminal
22 (142)	8 (350)	10 (270)	9 (229)	IPR002068: Heat shock protein Hsp20
20 (163)	7 (394)	2 (1033)	5 (427)	IPR002119: Histone H2A	Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
47 (55)	25 (90)	32 (61)	14 (144)	IPR000734: Lipase	Molecular Function: catalytic activity (GO:0003824), Biological Process: lipid metabolism (GO:0006629)
64 (42)	37 (65)	12 (241)	20 (90)	IPR007125: Histone core	Molecular Function: DNA binding (GO:0003677)
62 (43)	74 (30)	61 (34)	57 (30)	IPR006210: Type I EGF
13 (272)	4 (691)	5 (568)	2 (1173)	IPR008274: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
11 (307)	3 (816)	20 (126)	5 (445)	IPR004210: BESS motif	Molecular Function: DNA binding (GO:0003677)
146 (13)	155 (8)	121 (8)	120 (4)	IPR003599: Immunoglobulin subtype
9 (353)	16 (173)	()	()	IPR001309: Caspase, p20 subunit	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
155 (12)	163 (6)	102 (12)	97 (12)	IPR007110: Immunoglobulin-like
190 (9)	134 (9)	()	()	IPR000379: Esterase/lipase/thioesterase	Molecular Function: catalytic activity (GO:0003824)
19 (177)	27 (83)	10 (269)	9 (228)	IPR002007: Animal haem peroxidase	Molecular Function: peroxidase activity (GO:0004601)
25 (118)	12 (245)	14 (207)	7 (321)	IPR006047: Alpha amylase, catalytic region	Molecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
7 (437)	13 (219)	6 (432)	3 (669)	IPR001599: Alpha-2-macroglobulin	Molecular Function: endopeptidase inhibitor activity (GO:0004866)
48 (52)	28 (76)	40 (48)	15 (126)	IPR000073: Alpha/beta hydrolase fold
9 (378)	15 (196)	7 (404)	4 (605)	IPR011600: Peptidase C14, caspase catalytic subunit p20	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
36 (76)	20 (129)	15 (193)	5 (456)	IPR006026: Peptidase, metallopeptidases	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237)
13 (263)	5 (542)	5 (521)	1 (1490)	IPR002346: Molybdopterin dehydrogenase, FAD-binding	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
13 (253)	5 (511)	5 (496)	1 (1299)	IPR000674: Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
13 (264)	5 (549)	5 (528)	1 (1557)	IPR002888: [2Fe-2S]-binding
73 (34)	47 (47)	()	()	IPR007124: Histone-fold/TFIID-TAF/NF-Y	Molecular Function: DNA binding (GO:0003677)
48 (54)	29 (73)	35 (55)	10 (205)	IPR001304: C-type lectin	Molecular Function: sugar binding (GO:0005529)
12 (288)	18 (146)	17 (150)	9 (238)	IPR006076: FAD dependent oxidoreductase	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (356)	3 (758)	3 (771)	2 (932)	IPR001813: Ribosomal protein 60S	Molecular Function: structural constituent of ribosome (GO:0003735), Cellular Component: intracellular (GO:0005622), Cellular Component: ribosome (GO:0005840), Biological Process: translational elongation (GO:0006414)
9 (346)	3 (704)	3 (727)	3 (609)	IPR000101: Gamma-glutamyltranspeptidase	Molecular Function: gamma-glutamyltransferase activity (GO:0003840)
7 (468)	12 (251)	6 (480)	2 (1215)	IPR011626: A-macroglobulin complement component
46 (60)	53 (42)	24 (98)	24 (66)	IPR001878: Zinc finger, CCHC-type	Molecular Function: nucleic acid binding (GO:0003676)
39 (71)	23 (98)	28 (74)	15 (129)	IPR000873: AMP-dependent synthetase and ligase	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
7 (442)	2 (1059)	1 (1612)	1 (1514)	IPR002670: Ribosomal L18ae protein	Molecular Function: structural constituent of ribosome (GO:0003735), Cellular Component: intracellular (GO:0005622), Cellular Component: ribosome (GO:0005840), Biological Process: protein biosynthesis (GO:0006412)
7 (467)	2 (1281)	()	()	IPR009040: Ferritin-like
7 (426)	2 (969)	5 (501)	()	IPR000875: Cecropin	Cellular Component: extracellular region (GO:0005576), Biological Process: antibacterial humoral response (sensu Protostomia) (GO:0006961)
7 (465)	2 (1266)	3 (903)	2 (1174)	IPR008331: Ferritin and Dps	Biological Process: iron ion homeostasis (GO:0006879), Molecular Function: ferric iron binding (GO:0008199)
17 (201)	8 (364)	15 (194)	6 (387)	IPR006621: Nose resistant to fluoxetine-4, N-terminal
20 (164)	10 (286)	7 (381)	4 (551)	IPR003172: E1 protein and Def2/Der2 allergen
20 (169)	10 (294)	13 (220)	5 (461)	IPR006589: Alpha amylase, catalytic subdomain	Molecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
18 (194)	24 (97)	17 (156)	20 (92)	IPR012680: Laminin G, subdomain 2
9 (358)	14 (205)	()	()	IPR002138: Peptidase C14, caspase non-catalytic subunit p10	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
12 (287)	5 (561)	5 (551)	1 (1754)	IPR005107: CO dehydrogenase flavoprotein, C-terminal
12 (290)	5 (585)	6 (479)	5 (472)	IPR010625: CHCH
26 (112)	32 (70)	16 (170)	17 (113)	IPR002893: Zinc finger, MYND-type
10 (340)	4 (676)	3 (853)	3 (761)	IPR006115: 6-phosphogluconate dehydrogenase, NAD-binding	Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616), Biological Process: pentose-phosphate shunt (GO:0006098)
28 (102)	16 (174)	()	()	IPR001311: Solute-binding protein/glutamate receptor	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810)
25 (117)	14 (208)	15 (191)	7 (314)	IPR004262: Male sterility protein
87 (28)	91 (19)	71 (27)	55 (31)	IPR000276: Rhodopsin-like GPCR superfamily	Molecular Function: rhodopsin-like receptor activity (GO:0001584), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Cellular Component: integral to membrane (GO:0016021)
32 (85)	19 (133)	25 (91)	7 (301)	IPR001873: Na+ channel, amiloride-sensitive	Molecular Function: sodium channel activity (GO:0005272), Biological Process: sodium ion transport (GO:0006814), Cellular Component: membrane (GO:0016020)
13 (260)	6 (461)	4 (631)	4 (532)	IPR002075: Nuclear transport factor 2	Cellular Component: intracellular (GO:0005622), Cellular Component: nucleus (GO:0005634), Biological Process: protein-nucleus import (GO:0006606), Molecular Function: protein transporter activity (GO:0008565)
16 (215)	21 (118)	16 (177)	17 (116)	IPR012679: Laminin G, subdomain 1
8 (386)	3 (716)	2 (950)	2 (866)	IPR000585: Hemopexin
23 (133)	13 (218)	7 (358)	5 (413)	IPR000896: Arthropod hemocyanin/insect LSP	Molecular Function: oxygen transporter activity (GO:0005344), Biological Process: transport (GO:0006810)
9 (354)	13 (220)	12 (230)	13 (157)	IPR001610: PAC motif	Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Biological Process: signal transduction (GO:0007165)
20 (161)	11 (260)	12 (232)	14 (145)	IPR002035: von Willebrand factor, type A
38 (73)	24 (94)	()	()	IPR001472: Bipartite nuclear localization signal
17 (198)	9 (303)	9 (298)	4 (502)	IPR001041: Ferredoxin	Molecular Function: electron transporter activity (GO:0005489), Molecular Function: iron ion binding (GO:0005506), Biological Process: electron transport (GO:0006118)
76 (32)	53 (43)	72 (26)	53 (33)	IPR005828: General substrate transporter	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
72 (35)	75 (29)	68 (29)	71 (22)	IPR000210: BTB/POZ	Molecular Function: protein binding (GO:0005515)
28 (103)	17 (156)	13 (212)	3 (665)	IPR001506: Peptidase M12A, astacin	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: astacin activity (GO:0008533)
21 (157)	12 (250)	17 (155)	8 (278)	IPR011022: Arrestin, C-terminal
15 (229)	19 (135)	22 (108)	14 (147)	IPR002350: Proteinase inhibitor I1, Kazal
9 (372)	4 (684)	7 (396)	6 (389)	IPR007123: Gelsolin region
9 (357)	4 (629)	2 (1014)	2 (933)	IPR001818: Peptidase M10A and M12B, matrixin and adamalysin	Molecular Function: metalloendopeptidase activity (GO:0004222), Cellular Component: extracellular matrix (sensu Metazoa) (GO:0005578), Biological Process: proteolysis and peptidolysis (GO:0006508)
39 (70)	43 (52)	40 (47)	48 (35)	IPR000008: C2
40 (68)	26 (87)	24 (94)	23 (69)	IPR000626: Ubiquitin	Biological Process: protein modification (GO:0006464)
34 (79)	38 (59)	27 (78)	28 (52)	IPR001214: Nuclear protein SET
15 (227)	8 (349)	2 (1021)	4 (528)	IPR001951: Histone H4	Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
12 (276)	6 (436)	6 (413)	8 (246)	IPR000413: Integrins alpha chain	Biological Process: cell adhesion (GO:0007155), Biological Process: cell-matrix adhesion (GO:0007160), Cellular Component: integrin complex (GO:0008305)
21 (152)	25 (91)	18 (138)	23 (72)	IPR001791: Laminin G
29 (95)	18 (141)	23 (100)	22 (75)	IPR001202: WW/Rsp5/WWP
33 (83)	21 (110)	24 (96)	18 (104)	IPR000859: CUB
112 (21)	111 (14)	100 (14)	96 (13)	IPR003598: Immunoglobulin C2 type
7 (469)	10 (296)	6 (481)	2 (1216)	IPR011627: A-macroglobulin receptor
7 (450)	10 (291)	4 (659)	3 (730)	IPR004172: L27
8 (410)	11 (270)	10 (285)	14 (149)	IPR006935: Type III restriction enzyme, res subunit	Molecular Function: ATP binding (GO:0005524)
27 (105)	17 (152)	29 (70)	7 (282)	IPR000215: Proteinase inhibitor I4, serpin	Molecular Function: serine-type endopeptidase inhibitor activity (GO:0004867)
31 (90)	20 (127)	35 (57)	11 (187)	IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase	Biological Process: metabolism (GO:0008152), Molecular Function: transferase activity, transferring hexosyl groups (GO:0016758)
70 (37)	50 (45)	36 (54)	13 (162)	IPR006170: Pheromone/general odorant binding protein, PBP/GOBP	Molecular Function: odorant binding (GO:0005549), Biological Process: transport (GO:0006810)
10 (324)	5 (535)	6 (436)	8 (258)	IPR001763: Rhodanese-like
10 (331)	5 (555)	4 (648)	4 (550)	IPR003165: Stem cell self-renewal protein Piwi
58 (47)	60 (36)	()	()	IPR000742: EGF-like, subtype 2
24 (130)	15 (193)	51 (42)	9 (240)	IPR006578: MADF
24 (129)	15 (191)	10 (281)	5 (451)	IPR005203: Hemocyanin, C-terminal
11 (298)	14 (203)	14 (204)	12 (173)	IPR001876: Zinc finger, RanBP2-type
11 (310)	14 (211)	16 (173)	3 (777)	IPR006604: Disulphide knot CLIP
29 (97)	32 (69)	32 (63)	29 (50)	IPR001881: EGF-like calcium-binding	Molecular Function: calcium ion binding (GO:0005509)
17 (195)	10 (274)	6 (410)	11 (180)	IPR000315: Zinc finger, B-box	Cellular Component: intracellular (GO:0005622), Molecular Function: zinc ion binding (GO:0008270)
26 (113)	29 (75)	39 (51)	8 (267)	IPR004045: Glutathione S-transferase, N-terminal
15 (237)	18 (150)	19 (132)	13 (165)	IPR011705: BTB/Kelch-associated
21 (156)	24 (95)	()	()	IPR005820: Cation channel, non-ligand gated	Molecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
133 (17)	101 (15)	119 (9)	117 (5)	IPR001841: Zinc finger, RING-type	Cellular Component: ubiquitin ligase complex (GO:0000151), Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Molecular Function: zinc ion binding (GO:0008270), Biological Process: protein ubiquitination (GO:0016567)
18 (192)	21 (115)	17 (153)	19 (101)	IPR006670: Cyclin
14 (240)	8 (338)	11 (246)	6 (335)	IPR000668: Peptidase C1A, papain	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: cysteine-type peptidase activity (GO:0008234)
41 (67)	43 (54)	40 (50)	44 (37)	IPR006209: EGF-like
18 (181)	11 (254)	4 (578)	5 (399)	IPR000164: Histone H3	Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
8 (381)	4 (596)	8 (315)	10 (197)	IPR000313: PWWP
8 (407)	4 (670)	3 (849)	1 (1823)	IPR006048: Alpha amylase, C-terminal all-beta	Molecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
31 (89)	21 (113)	22 (107)	10 (208)	IPR001930: Peptidase M1, membrane alanine aminopeptidase	Molecular Function: membrane alanyl aminopeptidase activity (GO:0004179), Biological Process: proteolysis and peptidolysis (GO:0006508)
31 (88)	21 (108)	25 (88)	25 (63)	IPR000483: Cysteine-rich flanking region, C-terminal
73 (33)	54 (40)	56 (37)	43 (38)	IPR002198: Short-chain dehydrogenase/reductase SDR	Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491)
40 (69)	28 (77)	28 (75)	19 (95)	IPR001509: NAD-dependent epimerase/dehydratase	Molecular Function: catalytic activity (GO:0003824), Biological Process: nucleotide-sugar metabolism (GO:0009225), Molecular Function: NAD binding (GO:0051287)
23 (137)	15 (188)	4 (643)	8 (261)	IPR002919: Protease inhibitor I8, cysteine-rich trypsin inhibitor-like
12 (284)	7 (400)	6 (454)	4 (549)	IPR003146: Proteinase inhibitor, carboxypeptidase propeptide	Molecular Function: carboxypeptidase activity (GO:0004180), Biological Process: proteolysis and peptidolysis (GO:0006508)
12 (283)	7 (397)	6 (449)	4 (547)	IPR003100: Argonaute and Dicer protein, PAZ
12 (289)	7 (424)	9 (311)	3 (816)	IPR008914: PEBP
25 (115)	27 (80)	16 (166)	10 (204)	IPR001223: Glycoside hydrolase, family 18	Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
6 (500)	8 (348)	13 (214)	2 (939)	IPR001916: Glycoside hydrolase, family 22	Cellular Component: extracellular region (GO:0005576)
22 (145)	24 (96)	15 (196)	20 (91)	IPR007867: GMC oxidoreductase	Molecular Function: oxidoreductase activity, acting on CH-OH group of donors (GO:0016614), Molecular Function: FAD binding (GO:0050660)
7 (453)	9 (327)	9 (308)	8 (274)	IPR006575: RWD
7 (464)	9 (329)	9 (310)	9 (241)	IPR008145: Guanylate kinase/L-type calcium channel region
7 (423)	9 (301)	5 (495)	6 (334)	IPR000651: Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal	Molecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: small GTPase mediated signal transduction (GO:0007264)
16 (210)	10 (280)	12 (229)	19 (96)	IPR001609: Myosin head, motor region	Molecular Function: motor activity (GO:0003774), Molecular Function: ATP binding (GO:0005524), Cellular Component: myosin (GO:0016459)
24 (122)	16 (167)	34 (58)	18 (102)	IPR000301: CD9/CD37/CD63 antigen	Cellular Component: integral to membrane (GO:0016021)
20 (168)	22 (106)	21 (121)	21 (86)	IPR006202: Neurotransmitter-gated ion-channel ligand-binding	Molecular Function: extracellular ligand-gated ion channel activity (GO:0005230), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
51 (51)	37 (63)	42 (45)	40 (39)	IPR001965: Zinc finger, PHD-type	Molecular Function: protein binding (GO:0005515), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Molecular Function: zinc ion binding (GO:0008270)
9 (348)	5 (505)	5 (492)	5 (405)	IPR000462: CDP-alcohol phosphatidyltransferase	Biological Process: phospholipid biosynthesis (GO:0008654)
9 (355)	5 (534)	4 (627)	5 (425)	IPR001747: Lipid transport protein, N-terminal	Molecular Function: lipid transporter activity (GO:0005319), Biological Process: lipid transport (GO:0006869)
20 (162)	13 (221)	7 (374)	10 (209)	IPR002085: Alcohol dehydrogenase superfamily, zinc-containing	Molecular Function: zinc ion binding (GO:0008270), Molecular Function: oxidoreductase activity (GO:0016491)
9 (352)	11 (258)	6 (427)	9 (224)	IPR001258: NHL repeat
10 (323)	12 (235)	()	()	IPR001601: Generic methyltransferase	Molecular Function: methyltransferase activity (GO:0008168)
10 (320)	12 (232)	12 (228)	12 (172)	IPR001357: BRCT	Cellular Component: intracellular (GO:0005622)
6 (474)	3 (702)	3 (724)	3 (608)	IPR000058: Zinc finger, AN1-type	Molecular Function: molecular function unknown (GO:0005554)
15 (236)	17 (164)	22 (110)	13 (164)	IPR011497: Protease inhibitor, Kazal-type
15 (234)	17 (162)	13 (222)	15 (138)	IPR006671: Cyclin, N-terminal	Biological Process: regulation of progression through cell cycle (GO:0000074)
15 (216)	17 (151)	14 (198)	11 (179)	IPR000086: NUDIX hydrolase
11 (306)	13 (225)	16 (171)	14 (148)	IPR004161: Elongation factor Tu, domain 2	Molecular Function: GTP binding (GO:0005525)
11 (302)	13 (223)	12 (236)	11 (188)	IPR003131: K+ channel tetramerisation	Molecular Function: voltage-gated potassium channel activity (GO:0005249), Biological Process: potassium ion transport (GO:0006813), Cellular Component: voltage-gated potassium channel complex (GO:0008076), Cellular Component: membrane (GO:0016020)
14 (248)	16 (179)	()	()	IPR006195: Aminoacyl-transfer RNA synthetase, class II	Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
38 (75)	27 (84)	26 (86)	21 (83)	IPR002867: Zinc finger, C6HC-type
13 (258)	8 (346)	13 (213)	1 (1407)	IPR001604: DNA/RNA non-specific endonuclease	Molecular Function: nucleic acid binding (GO:0003676), Molecular Function: endonuclease activity (GO:0004519)
13 (257)	8 (345)	8 (327)	9 (226)	IPR001496: SOCS protein, C-terminal	Biological Process: intracellular signaling cascade (GO:0007242)
13 (273)	8 (370)	12 (242)	14 (151)	IPR008280: Tubulin/FtsZ, C-terminal	Molecular Function: GTPase activity (GO:0003924), Molecular Function: GTP binding (GO:0005525), Cellular Component: protein complex (GO:0043234), Biological Process: protein polymerization (GO:0051258)
58 (48)	43 (53)	58 (35)	53 (32)	IPR001092: Basic helix-loop-helix dimerisation region bHLH	Cellular Component: nucleus (GO:0005634), Molecular Function: transcription regulator activity (GO:0030528), Biological Process: regulation of transcription (GO:0045449)
17 (196)	11 (256)	9 (292)	11 (181)	IPR000408: Regulator of chromosome condensation, RCC1
17 (200)	11 (265)	13 (216)	10 (212)	IPR002999: Tudor	Molecular Function: nucleic acid binding (GO:0003676)
59 (46)	44 (50)	35 (56)	27 (56)	IPR002018: Carboxylesterase, type B
10 (327)	6 (467)	6 (446)	4 (536)	IPR002645: Sulfate transporter/antisigma-factor antagonist STAS
10 (339)	6 (486)	6 (468)	6 (384)	IPR006092: Acyl-CoA dehydrogenase, N-terminal	Molecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118)
10 (343)	6 (493)	3 (878)	2 (1140)	IPR007007: Ninjurin	Biological Process: cell adhesion (GO:0007155), Cellular Component: integral to membrane (GO:0016021), Biological Process: tissue regeneration (GO:0042246)
10 (321)	6 (451)	1 (1503)	2 (913)	IPR001360: Glycoside hydrolase, family 1	Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
60 (45)	45 (49)	56 (39)	63 (27)	IPR011511: Variant SH3
28 (104)	29 (74)	26 (85)	26 (60)	IPR002219: Protein kinase C, phorbol ester/diacylglycerol binding	Biological Process: intracellular signaling cascade (GO:0007242)
18 (190)	12 (242)	7 (385)	11 (193)	IPR003958: Transcription factor CBF/NF-Y/archaeal histone	Molecular Function: DNA binding (GO:0003677)
18 (185)	12 (234)	15 (185)	13 (156)	IPR001507: Endoglin/CD105 antigen
36 (77)	26 (89)	29 (73)	10 (218)	IPR006625: Insect pheromone/odorant binding protein PhBP
65 (40)	63 (34)	()	()	IPR001410: DEAD/DEAH box helicase	Molecular Function: ATP binding (GO:0005524), Molecular Function: ATP-dependent helicase activity (GO:0008026)
7 (425)	4 (610)	3 (746)	3 (638)	IPR000794: Beta-ketoacyl synthase	Molecular Function: catalytic activity (GO:0003824), Biological Process: fatty acid biosynthesis (GO:0006633)
7 (430)	4 (617)	4 (602)	5 (414)	IPR001117: Multicopper oxidase, type 1	Molecular Function: copper ion binding (GO:0005507)
7 (462)	4 (690)	()	()	IPR008139: Saposin B
7 (417)	4 (597)	3 (738)	3 (615)	IPR000322: Glycoside hydrolase, family 31	Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
7 (470)	4 (700)	5 (575)	5 (474)	IPR011706: Multicopper oxidase, type 2	Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491)
7 (461)	4 (687)	5 (564)	3 (798)	IPR007632: Protein of unknown function DUF590
7 (460)	4 (683)	4 (692)	3 (793)	IPR007122: Gelsolin	Molecular Function: actin binding (GO:0003779)
7 (420)	4 (602)	4 (584)	2 (861)	IPR000472: TGF-beta receptor/activin receptor, type I/II	Molecular Function: transmembrane receptor protein serine/threonine kinase activity (GO:0004675), Molecular Function: transforming growth factor beta receptor activity (GO:0005024), Cellular Component: membrane (GO:0016020)
7 (445)	4 (639)	5 (531)	7 (307)	IPR003034: DNA-binding SAP	Molecular Function: DNA binding (GO:0003677)
23 (134)	16 (172)	22 (104)	13 (154)	IPR001140: ABC transporter, transmembrane region	Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
28 (101)	20 (125)	26 (82)	4 (510)	IPR001283: Allergen V5/Tpx-1 related	Cellular Component: extracellular region (GO:0005576)
15 (220)	10 (275)	20 (124)	11 (183)	IPR000953: Chromo	Cellular Component: chromatin (GO:0000785), Molecular Function: chromatin binding (GO:0003682), Cellular Component: nucleus (GO:0005634), Biological Process: chromatin assembly or disassembly (GO:0006333)
15 (228)	10 (282)	11 (250)	9 (230)	IPR002086: Aldehyde dehydrogenase	Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491)
11 (295)	7 (378)	9 (293)	15 (128)	IPR000560: Histidine acid phosphatase	Molecular Function: acid phosphatase activity (GO:0003993)
11 (313)	7 (420)	()	()	IPR007107: LIM homeobox	Molecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Molecular Function: zinc ion binding (GO:0008270)
11 (299)	7 (395)	8 (330)	8 (260)	IPR002165: Plexin	Molecular Function: receptor activity (GO:0004872), Cellular Component: membrane (GO:0016020)
11 (297)	7 (391)	7 (371)	6 (355)	IPR001737: Ribosomal RNA adenine methylase transferase	Biological Process: rRNA modification (GO:0000154), Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179), Molecular Function: rRNA methyltransferase activity (GO:0008649)
17 (199)	18 (140)	18 (135)	18 (106)	IPR001163: Like-Sm ribonucleoprotein, core	Cellular Component: nucleus (GO:0005634), Cellular Component: small nucleolar ribonucleoprotein complex (GO:0005732), Biological Process: mRNA processing (GO:0006397)
29 (98)	21 (116)	()	()	IPR011527: ABC transporter, transmembrane region, type 1	Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
15 (225)	16 (177)	23 (101)	19 (98)	IPR001828: Extracellular ligand-binding receptor
15 (217)	16 (166)	16 (158)	15 (127)	IPR000242: Tyrosine specific protein phosphatase	Molecular Function: protein tyrosine phosphatase activity (GO:0004725), Biological Process: protein amino acid dephosphorylation (GO:0006470)
15 (219)	16 (170)	18 (134)	16 (123)	IPR000795: Protein synthesis factor, GTP-binding	Molecular Function: GTP binding (GO:0005525), Biological Process: protein biosynthesis (GO:0006412)
20 (171)	14 (215)	17 (154)	7 (329)	IPR011021: Arrestin, N-terminal
14 (243)	15 (187)	11 (249)	13 (158)	IPR002049: Laminin-type EGF-like	Molecular Function: structural molecule activity (GO:0005198)
14 (245)	15 (189)	15 (188)	13 (159)	IPR003595: Protein tyrosine phosphatase, catalytic region	Molecular Function: protein tyrosine phosphatase activity (GO:0004725)
14 (249)	15 (194)	18 (141)	16 (125)	IPR006594: Lissencephaly type-1-like homology motif
14 (239)	15 (181)	9 (291)	4 (481)	IPR000157: TIR	Molecular Function: transmembrane receptor activity (GO:0004888), Cellular Component: membrane (GO:0016020)
14 (241)	15 (184)	16 (163)	21 (81)	IPR000884: Thrombospondin, type I
13 (255)	14 (200)	13 (210)	12 (170)	IPR001159: Double-stranded RNA binding	Molecular Function: double-stranded RNA binding (GO:0003725), Cellular Component: intracellular (GO:0005622)
13 (256)	14 (201)	11 (248)	9 (225)	IPR001395: Aldo/keto reductase	Molecular Function: oxidoreductase activity (GO:0016491)
13 (259)	14 (202)	()	()	IPR001682: Ca2+/Na+ channel, pore region	Molecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
13 (261)	14 (204)	10 (271)	12 (174)	IPR002123: Phospholipid/glycerol acyltransferase	Biological Process: metabolism (GO:0008152), Molecular Function: acyltransferase activity (GO:0008415)
30 (92)	22 (102)	()	()	IPR000205: NAD-binding site
8 (388)	5 (512)	6 (417)	7 (287)	IPR000679: Zinc finger, GATA-type	Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
8 (401)	5 (544)	5 (525)	5 (433)	IPR002562: 3'-5' exonuclease	Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622), Molecular Function: 3'-5' exonuclease activity (GO:0008408)
8 (384)	5 (506)	()	()	IPR000513: 5'3'-Exonuclease N- and I-domain	Molecular Function: DNA binding (GO:0003677), Molecular Function: nuclease activity (GO:0004518)
8 (396)	5 (531)	5 (510)	3 (662)	IPR001424: Superoxide dismutase, copper/zinc binding	Molecular Function: copper, zinc superoxide dismutase activity (GO:0004785), Biological Process: superoxide metabolism (GO:0006801), Molecular Function: metal ion binding (GO:0046872)
10 (345)	11 (271)	9 (312)	9 (243)	IPR011547: Sulphate transporter	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
41 (65)	40 (58)	41 (46)	39 (41)	IPR003959: AAA ATPase, central region	Molecular Function: ATP binding (GO:0005524)
21 (155)	15 (192)	8 (343)	5 (452)	IPR005204: Hemocyanin, N-terminal
8 (409)	9 (325)	17 (151)	7 (322)	IPR006186: Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase	Molecular Function: hydrolase activity (GO:0016787)
8 (404)	9 (321)	11 (255)	11 (194)	IPR004344: Tubulin-tyrosine ligase	Molecular Function: tubulin-tyrosine ligase activity (GO:0004835), Biological Process: protein modification (GO:0006464)
8 (383)	9 (297)	10 (263)	10 (198)	IPR000337: GPCR, family 3, metabotropic glutamate receptor-like	Molecular Function: metabotropic glutamate, GABA-B-like receptor activity (GO:0008067), Cellular Component: membrane (GO:0016020)
8 (397)	9 (309)	6 (431)	10 (206)	IPR001590: Peptidase M12B, ADAM/reprolysin	Molecular Function: metalloendopeptidase activity (GO:0004222), Biological Process: proteolysis and peptidolysis (GO:0006508)
27 (107)	27 (82)	27 (79)	25 (64)	IPR001715: Calponin-like actin-binding
7 (435)	8 (344)	7 (369)	4 (518)	IPR001464: Annexin	Molecular Function: calcium ion binding (GO:0005509), Molecular Function: calcium-dependent phospholipid binding (GO:0005544)
7 (438)	8 (347)	6 (434)	5 (424)	IPR001627: Semaphorin/CD100 antigen
7 (466)	8 (373)	()	()	IPR009038: GOLD
7 (463)	8 (369)	7 (398)	7 (327)	IPR008144: Guanylate kinase
7 (432)	8 (342)	6 (426)	7 (296)	IPR001247: 3' exoribonuclease	Molecular Function: 3'-5'-exoribonuclease activity (GO:0000175), Molecular Function: RNA binding (GO:0003723), Biological Process: RNA processing (GO:0006396)
6 (493)	7 (390)	7 (366)	6 (347)	IPR001345: Phosphoglycerate/bisphosphoglycerate mutase	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
6 (488)	7 (381)	7 (360)	4 (500)	IPR000990: Innexin	Cellular Component: gap junction (GO:0005921)
6 (498)	7 (392)	5 (515)	6 (356)	IPR001762: Disintegrin
6 (492)	7 (388)	8 (324)	6 (345)	IPR001279: Beta-lactamase-like
6 (490)	7 (383)	6 (421)	7 (292)	IPR001025: Bromo adjacent region	Molecular Function: DNA binding (GO:0003677)
6 (484)	7 (380)	9 (295)	7 (290)	IPR000866: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
24 (124)	24 (93)	18 (133)	19 (94)	IPR000595: Cyclic nucleotide-binding
23 (135)	23 (99)	22 (106)	22 (76)	IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2	Molecular Function: cysteine-type endopeptidase activity (GO:0004197), Molecular Function: ubiquitin thiolesterase activity (GO:0004221), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511)
13 (268)	9 (323)	11 (256)	10 (217)	IPR006020: Phosphotyrosine interaction region
13 (252)	9 (298)	14 (199)	12 (169)	IPR000433: Zinc finger, ZZ-type	Molecular Function: zinc ion binding (GO:0008270)
123 (19)	99 (16)	130 (5)	98 (10)	IPR011701: Major facilitator superfamily MFS_1
22 (140)	22 (101)	21 (114)	21 (79)	IPR000195: RabGAP/TBC
22 (144)	22 (105)	32 (64)	6 (378)	IPR004046: Glutathione S-transferase, C-terminal
22 (139)	22 (100)	15 (178)	20 (87)	IPR000172: Glucose-methanol-choline oxidoreductase	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (375)	6 (495)	4 (698)	4 (592)	IPR008011: Complex 1 LYR protein	Cellular Component: mitochondrial inner membrane (GO:0005743), Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity, acting on NADH or NADPH (GO:0016651)
9 (349)	6 (438)	7 (356)	6 (333)	IPR000577: Carbohydrate kinase, FGGY	Biological Process: carbohydrate metabolism (GO:0005975)
9 (374)	6 (494)	9 (309)	7 (326)	IPR007889: Helix-turn-helix, Psq	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
9 (364)	6 (477)	8 (337)	8 (266)	IPR003903: Ubiquitin interacting motif
21 (159)	21 (117)	20 (130)	13 (166)	IPR012464: Protein of unknown function DUF1676
94 (24)	87 (22)	99 (15)	89 (14)	IPR001356: Homeobox	Molecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
18 (188)	13 (222)	16 (168)	15 (133)	IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin type	Biological Process: protein folding (GO:0006457)
28 (100)	21 (109)	24 (93)	26 (57)	IPR000571: Zinc finger, CCCH-type	Molecular Function: nucleic acid binding (GO:0003676)
23 (138)	17 (159)	28 (76)	21 (84)	IPR004088: KH, type 1	Molecular Function: nucleic acid binding (GO:0003676)
23 (136)	17 (158)	20 (125)	14 (146)	IPR002076: GNS1/SUR4 membrane protein	Cellular Component: integral to membrane (GO:0016021)
23 (132)	17 (154)	15 (180)	16 (120)	IPR000372: Cysteine-rich flanking region, N-terminal
19 (176)	19 (131)	16 (161)	18 (103)	IPR000536: Nuclear hormone receptor, ligand-binding	Molecular Function: transcription factor activity (GO:0003700), Molecular Function: steroid hormone receptor activity (GO:0003707), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
42 (63)	40 (57)	43 (44)	33 (43)	IPR002172: Low density lipoprotein-receptor, class A
18 (189)	18 (144)	17 (149)	17 (114)	IPR002917: GTP-binding protein, HSR1-related
236 (5)	212 (4)	207 (3)	201 (2)	IPR000719: Protein kinase	Molecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
24 (128)	18 (145)	29 (72)	23 (73)	IPR004087: KH	Molecular Function: nucleic acid binding (GO:0003676)
19 (175)	14 (198)	16 (159)	11 (182)	IPR000436: Sushi/SCR/CCP
19 (178)	14 (207)	15 (189)	15 (135)	IPR004000: Actin/actin-like	Molecular Function: protein binding (GO:0005515)
51 (50)	48 (46)	55 (40)	51 (34)	IPR001806: Ras GTPase	Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264)
369 (3)	307 (3)	243 (2)	58 (28)	IPR001254: Peptidase S1 and S6, chymotrypsin/Hap	Molecular Function: trypsin activity (GO:0004295), Biological Process: proteolysis and peptidolysis (GO:0006508)
88 (27)	81 (23)	76 (23)	74 (19)	IPR001650: Helicase, C-terminal	Molecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524)
16 (211)	16 (176)	16 (167)	9 (227)	IPR001734: Na+/solute symporter	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
16 (214)	16 (180)	19 (131)	17 (115)	IPR006662: Thioredoxin-related	Molecular Function: electron transporter activity (GO:0005489), Biological Process: electron transport (GO:0006118)
16 (206)	16 (169)	14 (201)	16 (122)	IPR000717: Proteasome component region PCI
16 (203)	16 (165)	16 (157)	13 (153)	IPR000014: PAS	Molecular Function: signal transducer activity (GO:0004871), Biological Process: signal transduction (GO:0007165)
16 (205)	16 (168)	12 (225)	16 (118)	IPR000306: Zinc finger, FYVE-type	Molecular Function: zinc ion binding (GO:0008270)
10 (337)	7 (410)	7 (392)	7 (320)	IPR005817: Wnt superfamily	Molecular Function: signal transducer activity (GO:0004871), Cellular Component: extracellular region (GO:0005576), Biological Process: frizzled-2 signaling pathway (GO:0007223), Biological Process: development (GO:0007275)
10 (341)	7 (416)	1 (1887)	1 (1839)	IPR006163: Phosphopantetheine-binding	Molecular Function: cofactor binding (GO:0048037)
25 (116)	19 (134)	()	()	IPR002293: Amino acid/polyamine transporter I	Molecular Function: amino acid-polyamine transporter activity (GO:0005279), Biological Process: amino acid transport (GO:0006865), Cellular Component: membrane (GO:0016020)
112 (20)	91 (20)	82 (20)	97 (11)	IPR002110: Ankyrin
15 (233)	15 (195)	20 (129)	8 (275)	IPR006631: Protein of unknown function DM4/12
15 (221)	15 (185)	26 (83)	13 (155)	IPR001353: 20S proteasome, A and B subunits	Molecular Function: threonine endopeptidase activity (GO:0004298), Cellular Component: proteasome core complex (sensu Eukaryota) (GO:0005839), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511)
48 (53)	45 (48)	30 (68)	20 (88)	IPR001251: Cellular retinaldehyde-binding/triple function, C-terminal
15 (223)	11 (259)	21 (117)	11 (185)	IPR001594: Zinc finger, DHHC-type	Molecular Function: metal ion binding (GO:0046872)
20 (165)	15 (190)	15 (192)	15 (137)	IPR004841: Amino acid permease-associated region	Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
6 (482)	4 (608)	3 (743)	3 (631)	IPR000716: Thyroglobulin type-1
6 (491)	4 (616)	3 (751)	3 (646)	IPR001026: Epsin, N-terminal
14 (247)	14 (209)	10 (283)	8 (270)	IPR006090: Acyl-CoA dehydrogenase, C-terminal	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
26 (109)	20 (123)	24 (95)	10 (201)	IPR000834: Peptidase M14, carboxypeptidase A	Molecular Function: carboxypeptidase A activity (GO:0004182), Biological Process: proteolysis and peptidolysis (GO:0006508)
12 (281)	12 (238)	12 (233)	9 (231)	IPR002159: CD36 antigen	Biological Process: cell adhesion (GO:0007155), Cellular Component: membrane (GO:0016020)
12 (275)	12 (227)	11 (245)	12 (168)	IPR000403: Phosphatidylinositol 3- and 4-kinase, catalytic	Molecular Function: phosphotransferase activity, alcohol group as acceptor (GO:0016773)
11 (308)	8 (362)	21 (119)	7 (318)	IPR005123: 2OG-Fe(II) oxygenase
11 (294)	8 (336)	1 (1423)	4 (491)	IPR000558: Histone H2B	Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
11 (312)	8 (366)	()	()	IPR007104: Paired-like homeobox	Molecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
11 (315)	8 (372)	6 (478)	3 (814)	IPR008758: Peptidase S28	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: serine-type peptidase activity (GO:0008236)
16 (209)	12 (231)	16 (165)	12 (171)	IPR001199: Cytochrome b5
16 (208)	12 (228)	14 (202)	6 (336)	IPR000772: Ricin B lectin
11 (309)	11 (267)	12 (240)	10 (216)	IPR005135: Endonuclease/exonuclease/phosphatase
11 (301)	11 (262)	13 (215)	10 (211)	IPR002423: Chaperonin Cpn60/TCP-1	Molecular Function: protein binding (GO:0005515), Molecular Function: ATP binding (GO:0005524), Biological Process: cellular protein metabolism (GO:0044267)
11 (296)	11 (257)	8 (320)	9 (221)	IPR000594: UBA/THIF-type NAD/FAD binding fold	Molecular Function: catalytic activity (GO:0003824)
11 (292)	11 (253)	10 (261)	7 (279)	IPR000033: Low-density lipoprotein receptor, YWTD repeat	Cellular Component: membrane (GO:0016020)
87 (29)	79 (26)	74 (25)	78 (17)	IPR011545: DEAD/DEAH box helicase, N-terminal	Molecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524)
33 (82)	26 (86)	31 (66)	28 (51)	IPR000048: IQ calmodulin-binding region
22 (141)	21 (112)	21 (118)	21 (82)	IPR001628: Nuclear hormone receptor, DNA-binding	Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
22 (143)	21 (114)	()	()	IPR002111: Cation (not K+) channel, TM region	Molecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
10 (336)	10 (293)	8 (341)	7 (317)	IPR005018: DOMON	Molecular Function: dopamine beta-monooxygenase activity (GO:0004500), Biological Process: catecholamine metabolism (GO:0006584)
10 (332)	10 (288)	7 (383)	8 (264)	IPR003594: ATP-binding region, ATPase-like	Molecular Function: ATP binding (GO:0005524)
10 (325)	10 (281)	8 (329)	7 (302)	IPR001895: Guanine-nucleotide dissociation stimulator CDC25	Molecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: intracellular signaling cascade (GO:0007242)
60 (44)	55 (39)	56 (36)	67 (25)	IPR000357: HEAT
77 (30)	70 (31)	67 (30)	78 (16)	IPR001849: Pleckstrin-like
21 (147)	20 (122)	22 (102)	10 (200)	IPR000832: GPCR, family 2, secretin-like	Molecular Function: G-protein coupled receptor activity (GO:0004930), Cellular Component: membrane (GO:0016020)
21 (149)	20 (124)	16 (164)	10 (203)	IPR001173: Glycosyl transferase, family 2
21 (154)	20 (128)	30 (69)	22 (77)	IPR003579: Ras small GTPase, Rab type	Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264), Biological Process: protein transport (GO:0015031)
17 (197)	13 (216)	16 (160)	16 (121)	IPR000467: D111/G-patch	Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622)
31 (87)	29 (72)	()	()	IPR000387: Tyrosine specific protein phosphatase and dual specificity protein phosphatase	Molecular Function: phosphoprotein phosphatase activity (GO:0004721), Biological Process: protein amino acid dephosphorylation (GO:0006470)
7 (440)	5 (539)	()	()	IPR001870: B302, (SPRY)-like
7 (456)	5 (570)	8 (347)	3 (779)	IPR006616: Protein of unknown function DM9
7 (459)	5 (571)	5 (559)	5 (463)	IPR006630: RNA-binding protein Lupus La
7 (421)	5 (509)	2 (949)	5 (407)	IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen	Molecular Function: binding (GO:0005488)
7 (439)	5 (538)	5 (517)	6 (357)	IPR001846: von Willebrand factor, type D
7 (424)	5 (513)	()	()	IPR000690: Zinc finger, C2H2-type matrin	Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634)
7 (471)	5 (590)	4 (718)	5 (475)	IPR011707: Multicopper oxidase, type 3	Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491)
9 (377)	9 (331)	7 (401)	2 (1186)	IPR009318: Trehalose receptor
9 (360)	9 (313)	()	()	IPR002341: HSF/ETS, DNA-binding	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
76 (31)	62 (35)	71 (28)	73 (20)	IPR001452: SH3
12 (278)	9 (304)	6 (422)	2 (892)	IPR001079: Galectin, galactose-binding lectin	Molecular Function: sugar binding (GO:0005529)
12 (280)	9 (311)	12 (231)	3 (676)	IPR001952: Alkaline phosphatase	Biological Process: metabolism (GO:0008152)
12 (279)	9 (310)	14 (203)	10 (207)	IPR001753: Enoyl-CoA hydratase/isomerase	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
20 (167)	19 (136)	21 (120)	21 (85)	IPR006029: Neurotransmitter-gated ion-channel transmembrane region	Biological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020), Molecular Function: neurotransmitter receptor activity (GO:0030594)
20 (172)	19 (138)	18 (143)	18 (110)	IPR011700: Basic leucine zipper	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
8 (389)	8 (339)	()	()	IPR000731: Sterol-sensing 5TM box
8 (415)	8 (374)	()	()	IPR013017: NHL
8 (398)	8 (351)	6 (441)	8 (259)	IPR002073: 3'5'-cyclic nucleotide phosphodiesterase	Molecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114), Biological Process: signal transduction (GO:0007165)
8 (405)	8 (361)	7 (390)	7 (315)	IPR004365: nucleic acid binding, OB-fold, tRNA/helicase-type	Molecular Function: nucleic acid binding (GO:0003676)
8 (411)	8 (367)	10 (286)	6 (390)	IPR007248: Mpv17/PMP22	Cellular Component: integral to membrane (GO:0016021)
29 (94)	27 (79)	32 (60)	27 (54)	IPR000608: Ubiquitin-conjugating enzyme, E2	Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512), Molecular Function: ubiquitin-like activating enzyme activity (GO:0008642)
19 (180)	18 (148)	16 (175)	18 (109)	IPR011498: Kelch
19 (174)	18 (139)	17 (145)	16 (119)	IPR000330: SNF2-related	Molecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524)
135 (16)	112 (13)	122 (7)	116 (6)	IPR003593: AAA ATPase	Molecular Function: nucleotide binding (GO:0000166), Molecular Function: nucleoside-triphosphatase activity (GO:0017111)
47 (57)	38 (62)	54 (41)	13 (160)	IPR004119: Protein of unknown function DUF227	Molecular Function: molecular function unknown (GO:0005554)
47 (56)	38 (61)	36 (53)	28 (53)	IPR001810: Cyclin-like F-box
7 (451)	7 (412)	8 (344)	8 (268)	IPR005824: KOW
7 (441)	7 (396)	7 (376)	7 (304)	IPR002553: Adaptin, N-terminal
7 (447)	7 (404)	12 (238)	6 (373)	IPR003650: Orange	Molecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
7 (429)	7 (384)	6 (423)	7 (294)	IPR001093: IMP dehydrogenase/GMP reductase	Molecular Function: catalytic activity (GO:0003824)
7 (472)	7 (428)	6 (482)	5 (476)	IPR011765: Peptidase M16, N-terminal
7 (418)	7 (376)	10 (264)	6 (331)	IPR000348: emp24/gp25L/p24	Biological Process: intracellular protein transport (GO:0006886), Molecular Function: protein carrier activity (GO:0008320), Cellular Component: membrane (GO:0016020)
7 (433)	7 (389)	4 (614)	3 (657)	IPR001310: Histidine triad (HIT) protein
7 (454)	7 (418)	8 (345)	7 (324)	IPR006595: CTLH, C-terminal to LisH motif
7 (452)	7 (417)	6 (472)	9 (239)	IPR006560: AWS
7 (431)	7 (386)	()	()	IPR001201: PAP/25A core	Molecular Function: nucleic acid binding (GO:0003676)
7 (416)	7 (375)	6 (407)	5 (397)	IPR000095: PAK-box/P21-Rho-binding
7 (457)	7 (419)	11 (259)	4 (585)	IPR006619: Animal peptidoglycan recognition protein PGRP	Molecular Function: protein binding (GO:0005515)
46 (59)	42 (55)	()	()	IPR000051: SAM (and some other nucleotide) binding motif	Molecular Function: S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)
24 (123)	19 (130)	26 (81)	19 (93)	IPR000449: Ubiquitin-associated
18 (187)	17 (157)	9 (300)	15 (132)	IPR002017: Spectrin repeat
13 (265)	10 (284)	12 (235)	15 (134)	IPR003008: Tubulin/FtsZ, GTPase
6 (483)	6 (443)	2 (963)	1 (1310)	IPR000757: Glycoside hydrolase, family 16	Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
6 (480)	6 (434)	4 (583)	5 (402)	IPR000331: Rap/ran-GAP
6 (479)	6 (432)	4 (582)	4 (486)	IPR000323: Copper type II, ascorbate-dependent monooxygenase	Molecular Function: monooxygenase activity (GO:0004497), Molecular Function: copper ion binding (GO:0005507)
6 (473)	6 (429)	4 (576)	5 (396)	IPR000034: Laminin B
6 (485)	6 (444)	6 (419)	6 (338)	IPR000904: SEC7-like
6 (499)	6 (460)	7 (373)	4 (526)	IPR001879: Hormone receptor, extracellular	Molecular Function: G-protein coupled receptor activity (GO:0004930), Cellular Component: membrane (GO:0016020)
6 (475)	6 (431)	6 (408)	4 (480)	IPR000120: Amidase	Molecular Function: amidase activity (GO:0004040)
6 (497)	6 (456)	4 (623)	3 (668)	IPR001597: Aromatic amino acid beta-eliminating lyase/threonine aldolase	Biological Process: amino acid metabolism (GO:0006520), Molecular Function: lyase activity (GO:0016829)
6 (481)	6 (439)	6 (415)	5 (408)	IPR000591: Pleckstrin/ G-protein, interacting region	Biological Process: intracellular signaling cascade (GO:0007242)
6 (487)	6 (445)	7 (359)	7 (291)	IPR000938: CAP-Gly
8 (395)	6 (453)	7 (368)	7 (297)	IPR001375: Peptidase S9, prolyl oligopeptidase active site region	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: serine-type peptidase activity (GO:0008236)
8 (393)	6 (449)	4 (611)	5 (417)	IPR001298: Filamin/ABP280 repeat
8 (400)	6 (465)	7 (375)	6 (360)	IPR002524: Cation efflux protein	Biological Process: cation transport (GO:0006812), Molecular Function: cation transporter activity (GO:0008324), Cellular Component: membrane (GO:0016020)
8 (402)	6 (472)	7 (380)	7 (308)	IPR003107: RNA-processing protein, HAT helix	Cellular Component: intracellular (GO:0005622), Biological Process: RNA processing (GO:0006396)
8 (387)	6 (441)	5 (494)	7 (286)	IPR000644: CBS
8 (406)	6 (482)	6 (462)	6 (380)	IPR004367: Cyclin, C-terminal	Biological Process: regulation of progression through cell cycle (GO:0000074), Cellular Component: nucleus (GO:0005634)
8 (382)	6 (433)	10 (262)	5 (401)	IPR000326: Phosphoesterase, PA-phosphatase related
8 (394)	6 (452)	7 (367)	6 (348)	IPR001373: Cullin	Biological Process: cell cycle (GO:0007049)
8 (380)	6 (430)	6 (406)	7 (281)	IPR000089: Biotin/lipoyl attachment
8 (385)	6 (437)	5 (493)	3 (621)	IPR000539: Frizzled protein	Molecular Function: non-G-protein coupled 7TM receptor activity (GO:0004926), Biological Process: cell surface receptor linked signal transduction (GO:0007166), Cellular Component: membrane (GO:0016020)
93 (25)	77 (27)	76 (22)	75 (18)	IPR001440: TPR repeat
19 (173)	15 (182)	17 (144)	21 (80)	IPR000225: Armadillo
25 (114)	20 (120)	21 (113)	17 (111)	IPR000182: GCN5-related N-acetyltransferase	Molecular Function: N-acetyltransferase activity (GO:0008080)
42 (62)	38 (60)	()	()	IPR001622: K+ channel, pore region	Molecular Function: potassium channel activity (GO:0005267), Biological Process: potassium ion transport (GO:0006813), Cellular Component: membrane (GO:0016020)
67 (39)	60 (37)	61 (32)	58 (29)	IPR003961: Fibronectin, type III
26 (110)	21 (111)	22 (103)	23 (70)	IPR000910: HMG1/2 (high mobility group) box	Molecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
15 (218)	14 (199)	14 (200)	14 (143)	IPR000569: HECT	Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Cellular Component: intracellular (GO:0005622), Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512)
15 (231)	14 (210)	13 (219)	8 (271)	IPR006091: Acyl-CoA dehydrogenase, central region	Molecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118)
15 (235)	14 (214)	14 (208)	14 (150)	IPR007502: Helicase-associated region	Molecular Function: helicase activity (GO:0004386)
24 (125)	22 (104)	25 (90)	18 (105)	IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase	Biological Process: intracellular signaling cascade (GO:0007242), Biological Process: cyclic nucleotide biosynthesis (GO:0009190), Molecular Function: phosphorus-oxygen lyase activity (GO:0016849)
64 (41)	53 (41)	()	()	IPR001687: ATP/GTP-binding site motif A (P-loop)	Molecular Function: ATP binding (GO:0005524)
9 (365)	7 (406)	6 (461)	6 (377)	IPR004038: Ribosomal protein L7Ae/L30e/S12e/Gadd45
9 (350)	7 (385)	11 (247)	8 (252)	IPR001107: Band 7 protein
9 (366)	7 (409)	8 (342)	6 (381)	IPR005024: Snf7	Molecular Function: molecular function unknown (GO:0005554)
9 (369)	7 (414)	2 (1201)	1 (1828)	IPR006088: Sterol desaturase	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
9 (379)	7 (426)	9 (313)	12 (178)	IPR011704: ATPase associated with various cellular activities, AAA_5	Molecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887)
9 (368)	7 (411)	3 (846)	4 (573)	IPR005818: Histone H1/H5	Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334)
14 (244)	13 (224)	13 (218)	24 (67)	IPR003534: Major royal jelly protein
15 (232)	12 (246)	13 (221)	1 (1851)	IPR006593: Cytochrome b561 / ferric reductase transmembrane
15 (230)	12 (239)	8 (334)	6 (366)	IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase	Biological Process: nitrogen compound metabolism (GO:0006807), Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)
15 (226)	12 (237)	15 (187)	11 (186)	IPR001932: Protein phosphatase 2C-like	Molecular Function: catalytic activity (GO:0003824)
15 (222)	12 (233)	15 (184)	8 (256)	IPR001494: Importin-beta, N-terminal	Biological Process: protein-nucleus import, docking (GO:0000059), Cellular Component: nucleus (GO:0005634), Cellular Component: nuclear pore (GO:0005643), Cellular Component: cytoplasm (GO:0005737), Molecular Function: protein transporter activity (GO:0008565)
15 (224)	12 (236)	8 (328)	6 (353)	IPR001699: Transcription factor, T-box	Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
15 (238)	12 (252)	13 (224)	11 (196)	IPR011709: Protein of unknown function DUF1605	Molecular Function: ATP binding (GO:0005524), Molecular Function: ATP-dependent helicase activity (GO:0008026)
21 (148)	17 (155)	24 (97)	24 (65)	IPR001005: Myb, DNA-binding	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
72 (36)	64 (33)	63 (31)	66 (26)	IPR001478: PDZ/DHR/GLGF	Molecular Function: protein binding (GO:0005515)
34 (81)	28 (78)	32 (65)	19 (99)	IPR004843: Metallophosphoesterase	Molecular Function: hydrolase activity (GO:0016787)
13 (266)	12 (240)	12 (237)	11 (191)	IPR003604: Zinc finger, U1-type	Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270)
13 (271)	12 (249)	15 (197)	9 (242)	IPR008191: Maternal tudor protein
13 (270)	12 (248)	()	()	IPR007092: Leucine-rich repeat, SDS22+-like
13 (250)	12 (226)	12 (226)	12 (167)	IPR000340: Dual specificity protein phosphatase	Biological Process: protein amino acid dephosphorylation (GO:0006470), Molecular Function: protein tyrosine/serine/threonine phosphatase activity (GO:0008138)
13 (254)	12 (230)	15 (183)	10 (202)	IPR001148: Carbonic anhydrase, eukaryotic	Molecular Function: carbonate dehydratase activity (GO:0004089), Biological Process: one-carbon compound metabolism (GO:0006730), Molecular Function: zinc ion binding (GO:0008270)
13 (267)	12 (244)	10 (282)	9 (237)	IPR005804: Fatty acid desaturase	Molecular Function: oxidoreductase activity (GO:0016491)
21 (151)	19 (132)	18 (137)	15 (131)	IPR001766: Fork head transcription factor	Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
16 (207)	13 (217)	12 (227)	9 (222)	IPR000727: Target SNARE coiled-coil region
10 (322)	8 (343)	6 (429)	6 (350)	IPR001433: Oxidoreductase FAD/NAD(P)-binding	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
10 (326)	8 (352)	8 (331)	9 (232)	IPR002300: Aminoacyl-tRNA synthetase, class Ia	Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
10 (330)	8 (356)	9 (304)	5 (436)	IPR002939: Chaperone DnaJ, C-terminal	Biological Process: protein folding (GO:0006457), Molecular Function: unfolded protein binding (GO:0051082)
10 (316)	8 (335)	8 (318)	7 (284)	IPR000488: Death	Molecular Function: protein binding (GO:0005515), Biological Process: signal transduction (GO:0007165)
12 (285)	11 (266)	10 (279)	15 (136)	IPR004273: Dynein heavy chain	Molecular Function: microtubule motor activity (GO:0003777), Biological Process: microtubule-based movement (GO:0007018), Cellular Component: dynein complex (GO:0030286)
29 (96)	26 (88)	29 (71)	26 (58)	IPR001660: Sterile alpha motif SAM
198 (7)	173 (5)	184 (4)	184 (3)	IPR001680: WD-40 repeat
20 (170)	18 (147)	17 (152)	19 (100)	IPR006652: Kelch repeat
144 (14)	126 (11)	128 (6)	114 (7)	IPR000504: RNA-binding region RNP-1 (RNA recognition motif)	Molecular Function: nucleic acid binding (GO:0003676)
11 (303)	10 (287)	10 (276)	11 (190)	IPR003577: Ras small GTPase, Ras type	Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264)
11 (311)	10 (295)	13 (223)	13 (163)	IPR006689: ARF/SAR superfamily	Molecular Function: GTP binding (GO:0005525)
11 (291)	10 (273)	8 (314)	5 (395)	IPR000024: Frizzled CRD region
11 (305)	10 (290)	11 (252)	11 (192)	IPR003659: Plexin/semaphorin/integrin	Biological Process: development (GO:0007275)
11 (304)	10 (289)	10 (277)	10 (214)	IPR003607: Metal-dependent phosphohydrolase, HD region	Molecular Function: catalytic activity (GO:0003824)
17 (202)	14 (213)	()	()	IPR007089: Leucine-rich repeat, cysteine-containing
19 (179)	17 (160)	20 (127)	20 (89)	IPR004827: Basic-leucine zipper (bZIP) transcription factor	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
35 (78)	31 (71)	32 (62)	31 (47)	IPR000980: SH2 motif	Biological Process: intracellular signaling cascade (GO:0007242)
11 (293)	9 (300)	10 (265)	9 (220)	IPR000555: Mov34/MPN/PAD-1
11 (300)	9 (312)	12 (234)	12 (175)	IPR002225: 3-beta hydroxysteroid dehydrogenase/isomerase	Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity (GO:0003854), Biological Process: steroid biosynthesis (GO:0006694)
24 (126)	20 (126)	26 (84)	26 (59)	IPR001752: Kinesin, motor region	Molecular Function: microtubule motor activity (GO:0003777), Molecular Function: ATP binding (GO:0005524), Cellular Component: microtubule associated complex (GO:0005875), Biological Process: microtubule-based movement (GO:0007018)
24 (119)	20 (119)	21 (112)	14 (141)	IPR000175: Sodium:neurotransmitter symporter	Molecular Function: neurotransmitter:sodium symporter activity (GO:0005328), Cellular Component: integral to plasma membrane (GO:0005887), Biological Process: neurotransmitter transport (GO:0006836), Cellular Component: membrane (GO:0016020)
24 (121)	20 (121)	21 (115)	22 (74)	IPR000299: Band 4.1	Cellular Component: cytoskeleton (GO:0005856)
10 (319)	9 (307)	4 (612)	4 (512)	IPR001300: Peptidase C2, calpain	Molecular Function: calpain activity (GO:0004198), Cellular Component: intracellular (GO:0005622), Biological Process: proteolysis and peptidolysis (GO:0006508)
10 (317)	9 (305)	7 (363)	9 (223)	IPR001164: Arf GTPase activating protein	Biological Process: regulation of GTPase activity (GO:0043087)
10 (318)	9 (306)	8 (322)	7 (295)	IPR001179: Peptidylprolyl isomerase, FKBP-type	Biological Process: protein folding (GO:0006457)
10 (329)	9 (316)	18 (140)	6 (363)	IPR002933: Peptidase M20	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237)
10 (335)	9 (322)	8 (340)	7 (316)	IPR004837: Sodium/calcium exchanger membrane region	Cellular Component: integral to membrane (GO:0016021)
10 (338)	9 (324)	()	()	IPR006087: SUR2-type hydroxylase/desaturase, catalytic region	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
10 (342)	9 (326)	11 (257)	7 (323)	IPR006569: Regulation of nuclear pre-mRNA protein
10 (334)	9 (320)	14 (206)	16 (124)	IPR004148: BAR	Molecular Function: protein binding (GO:0005515), Cellular Component: cytoplasm (GO:0005737)
10 (333)	9 (319)	9 (305)	8 (265)	IPR003689: Zinc/iron permease	Cellular Component: membrane (GO:0016020), Biological Process: metal ion transport (GO:0030001), Molecular Function: metal ion transporter activity (GO:0046873)
10 (328)	9 (315)	10 (273)	7 (305)	IPR002909: Cell surface receptor IPT/TIG
10 (344)	9 (328)	15 (195)	5 (467)	IPR007484: Peptidase M28	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: peptidase activity (GO:0008233)
18 (182)	15 (183)	17 (146)	14 (142)	IPR000412: ABC-2	Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
18 (184)	15 (186)	18 (136)	18 (107)	IPR001487: Bromodomain
38 (74)	32 (68)	40 (49)	27 (55)	IPR001623: Heat shock protein DnaJ, N-terminal	Biological Process: protein folding (GO:0006457), Molecular Function: heat shock protein binding (GO:0031072), Molecular Function: unfolded protein binding (GO:0051082)
18 (183)	16 (171)	10 (267)	7 (289)	IPR000863: Sulfotransferase	Molecular Function: sulfotransferase activity (GO:0008146)
18 (191)	16 (178)	28 (77)	13 (161)	IPR004272: Odorant binding protein	Molecular Function: molecular function unknown (GO:0005554)
18 (186)	16 (175)	15 (186)	19 (97)	IPR001683: Phox-like	Biological Process: intracellular signaling cascade (GO:0007242)
107 (23)	91 (21)	103 (11)	100 (9)	IPR002290: Serine/threonine protein kinase	Molecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
32 (86)	27 (85)	()	()	IPR006663: Thioredoxin domain 2	Molecular Function: electron transporter activity (GO:0005489), Biological Process: electron transport (GO:0006118)
32 (84)	27 (81)	30 (67)	30 (49)	IPR001245: Tyrosine protein kinase	Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
12 (286)	10 (292)	10 (280)	10 (215)	IPR004839: Aminotransferase, class I and II	Biological Process: biosynthesis (GO:0009058), Molecular Function: transferase activity, transferring nitrogenous groups (GO:0016769)
12 (277)	10 (276)	9 (296)	8 (251)	IPR000994: Peptidase M24	Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metalloexopeptidase activity (GO:0008235)
12 (282)	10 (285)	10 (274)	10 (213)	IPR003029: RNA binding S1	Molecular Function: RNA binding (GO:0003723)
136 (15)	116 (12)	76 (24)	72 (21)	IPR003591: Leucine-rich repeat, typical subtype
39 (72)	33 (67)	34 (59)	31 (48)	IPR001781: LIM, zinc-binding	Molecular Function: zinc ion binding (GO:0008270)
9 (376)	8 (371)	6 (477)	3 (812)	IPR008334: 5'-Nucleotidase, C-terminal	Biological Process: nucleotide catabolism (GO:0009166), Molecular Function: hydrolase activity (GO:0016787)
9 (371)	8 (365)	10 (284)	10 (219)	IPR006688: ADP-ribosylation factor	Molecular Function: GTP binding (GO:0005525)
9 (359)	8 (353)	9 (301)	9 (233)	IPR002314: tRNA synthetase, class II (G, H, P and S)	Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
9 (363)	8 (357)	4 (654)	9 (234)	IPR003616: SET-related region
9 (362)	8 (355)	8 (333)	6 (364)	IPR002937: Amine oxidase	Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (351)	8 (341)	7 (364)	8 (254)	IPR001208: MCM	Molecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524), Biological Process: DNA replication initiation (GO:0006270), Molecular Function: DNA-dependent ATPase activity (GO:0008094)
9 (370)	8 (363)	4 (689)	4 (584)	IPR006603: Cystinosin/ERS1p repeat
9 (347)	8 (334)	8 (317)	8 (247)	IPR000418: Ets	Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
9 (361)	8 (354)	11 (251)	5 (432)	IPR002502: N-acetylmuramoyl-L-alanine amidase, family 2	Molecular Function: N-acetylmuramoyl-L-alanine amidase activity (GO:0008745), Biological Process: peptidoglycan catabolism (GO:0009253)
9 (373)	8 (368)	7 (397)	8 (276)	IPR007863: Peptidase M16, C-terminal
26 (111)	22 (103)	25 (89)	23 (71)	IPR000961: Protein kinase, C-terminal	Molecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
6 (476)	5 (498)	2 (936)	1 (1257)	IPR000183: Orn/DAP/Arg decarboxylase 2	Molecular Function: catalytic activity (GO:0003824)
6 (478)	5 (502)	5 (488)	4 (485)	IPR000286: Histone deacetylase superfamily
6 (495)	5 (528)	4 (618)	5 (420)	IPR001392: Clathrin adaptor complex, medium chain	Biological Process: intracellular protein transport (GO:0006886), Cellular Component: clathrin vesicle coat (GO:0030125)
6 (489)	5 (523)	6 (420)	6 (341)	IPR001017: Dehydrogenase, E1 component	Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624)
6 (486)	5 (522)	4 (598)	6 (339)	IPR000909: Phosphatidylinositol-specific phospholipase C, X region	Molecular Function: phospholipase C activity (GO:0004629), Biological Process: signal transduction (GO:0007165), Biological Process: intracellular signaling cascade (GO:0007242)
6 (496)	5 (530)	3 (764)	4 (516)	IPR001404: Heat shock protein Hsp90	Biological Process: protein folding (GO:0006457), Molecular Function: unfolded protein binding (GO:0051082)
6 (494)	5 (527)	8 (326)	4 (513)	IPR001365: Adenosine/AMP deaminase	Biological Process: purine ribonucleoside monophosphate biosynthesis (GO:0009168), Molecular Function: deaminase activity (GO:0019239)
6 (477)	5 (499)	5 (486)	6 (330)	IPR000209: Peptidase S8 and S53, subtilisin, kexin, sedolisin	Molecular Function: subtilase activity (GO:0004289), Biological Process: proteolysis and peptidolysis (GO:0006508)
24 (120)	21 (107)	20 (122)	23 (68)	IPR000198: RhoGAP
68 (38)	58 (38)	56 (38)	39 (40)	IPR003439: ABC transporter related	Molecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887)
16 (204)	14 (197)	11 (244)	14 (140)	IPR000159: RA	Biological Process: signal transduction (GO:0007165)
16 (212)	14 (206)	13 (217)	11 (189)	IPR003347: Transcription factor jumonji, jmjC
16 (213)	14 (212)	16 (174)	6 (388)	IPR006629: LPS-induced tumor necrosis factor alpha factor
13 (269)	11 (268)	9 (307)	8 (273)	IPR006553: Leucine-rich repeat, cysteine-containing subtype
13 (262)	11 (261)	10 (272)	10 (210)	IPR002129: Pyridoxal-dependent decarboxylase	Biological Process: amino acid metabolism (GO:0006520), Molecular Function: carboxy-lyase activity (GO:0016831)
13 (274)	11 (272)	14 (209)	14 (152)	IPR011616: bZIP transcription factor, bZIP_1	Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
13 (251)	11 (255)	8 (316)	10 (199)	IPR000342: Regulator of G protein signalling	Molecular Function: signal transducer activity (GO:0004871)
112 (22)	97 (18)	()	()	IPR007114: Major facilitator superfamily	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
90 (26)	77 (28)	84 (19)	69 (23)	IPR002048: Calcium-binding EF-hand	Molecular Function: calcium ion binding (GO:0005509)
20 (166)	17 (161)	26 (87)	18 (108)	IPR005834: Haloacid dehalogenase-like hydrolase	Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
20 (160)	17 (153)	15 (179)	16 (117)	IPR000253: Forkhead-associated
41 (64)	35 (66)	46 (43)	32 (45)	IPR001993: Mitochondrial substrate carrier	Molecular Function: binding (GO:0005488), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
8 (408)	7 (413)	7 (393)	8 (269)	IPR006055: Exonuclease	Molecular Function: exonuclease activity (GO:0004527), Cellular Component: intracellular (GO:0005622)
8 (391)	7 (382)	7 (361)	6 (342)	IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit	Molecular Function: signal transducer activity (GO:0004871), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Molecular Function: guanyl nucleotide binding (GO:0019001)
8 (403)	7 (405)	10 (278)	6 (374)	IPR003890: Initiation factor eIF-4 gamma, middle	Molecular Function: RNA binding (GO:0003723)
8 (413)	7 (423)	8 (349)	11 (195)	IPR008250: E1-E2 ATPase-associated region	Molecular Function: ATP binding (GO:0005524), Cellular Component: membrane (GO:0016020), Molecular Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)
8 (412)	7 (422)	6 (476)	5 (468)	IPR008211: Laminin, N-terminal	Cellular Component: extracellular matrix (sensu Metazoa) (GO:0005578)
8 (399)	7 (393)	5 (519)	5 (426)	IPR002083: MATH
8 (392)	7 (387)	8 (323)	8 (253)	IPR001206: Diacylglycerol kinase, catalytic region	Molecular Function: diacylglycerol kinase activity (GO:0004143), Biological Process: protein kinase C activation (GO:0007205)
8 (390)	7 (379)	()	()	IPR000862: Replication factor C conserved region	Molecular Function: DNA binding (GO:0003677), Biological Process: DNA replication (GO:0006260), Cellular Component: protein complex (GO:0043234)
8 (414)	7 (427)	()	()	IPR011761: ATP-grasp fold	Molecular Function: catalytic activity (GO:0003824)
28 (99)	24 (92)	20 (123)	25 (62)	IPR000219: DH
21 (150)	18 (142)	22 (105)	15 (130)	IPR001320: Ionotropic glutamate receptor	Molecular Function: ionotropic glutamate receptor activity (GO:0004970), Molecular Function: glutamate-gated ion channel activity (GO:0005234), Cellular Component: membrane (GO:0016020)
21 (153)	18 (143)	16 (169)	12 (176)	IPR002422: Amino acid/polyamine transporter II	Molecular Function: amino acid-polyamine transporter activity (GO:0005279), Biological Process: amino acid transport (GO:0006865), Cellular Component: membrane (GO:0016020)
21 (158)	18 (149)	22 (111)	22 (78)	IPR011510: Sterile alpha motif homology 2
14 (246)	12 (241)	12 (239)	12 (177)	IPR003877: SPla/RYanodine receptor SPRY
14 (242)	12 (229)	15 (181)	11 (184)	IPR001007: von Willebrand factor, type C
22 (146)	19 (137)	16 (176)	9 (244)	IPR011583: Chitinase II	Molecular Function: chitinase activity (GO:0004568), Biological Process: chitin catabolism (GO:0006032)
181 (10)	156 (7)	107 (10)	107 (8)	IPR001611: Leucine-rich repeat
7 (458)	6 (491)	24 (99)	6 (386)	IPR006620: Prolyl 4-hydroxylase, alpha subunit	Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706), Biological Process: protein metabolism (GO:0019538)
7 (443)	6 (468)	6 (448)	6 (362)	IPR002877: Ribosomal RNA methyltransferase RrmJ/FtsJ
7 (446)	6 (471)	6 (450)	6 (367)	IPR003104: Actin-binding FH2	Molecular Function: actin binding (GO:0003779), Biological Process: cell organization and biogenesis (GO:0016043)
7 (455)	6 (489)	7 (394)	5 (462)	IPR006596: Nucleotide binding protein, PINc
7 (434)	6 (450)	8 (325)	6 (346)	IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase	Biological Process: electron transport (GO:0006118), Molecular Function: disulfide oxidoreductase activity (GO:0015036)
7 (449)	6 (479)	8 (339)	7 (312)	IPR004156: Organic anion transporter polypeptide OATP	Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
7 (444)	6 (469)	()	()	IPR003009: FMN/related compound-binding core
7 (436)	6 (455)	7 (370)	8 (257)	IPR001529: DNA-directed RNA polymerase, M/15 kDa subunit	Molecular Function: DNA binding (GO:0003677), Molecular Function: DNA-directed RNA polymerase activity (GO:0003899), Biological Process: transcription (GO:0006350)
7 (419)	6 (435)	5 (490)	5 (403)	IPR000409: Beige/BEACH
7 (422)	6 (440)	6 (416)	7 (285)	IPR000640: Elongation factor G, C-terminal	Molecular Function: GTP binding (GO:0005525)
7 (448)	6 (478)	8 (338)	9 (235)	IPR004012: RUN
7 (428)	6 (447)	5 (504)	7 (293)	IPR001060: Cdc15/Fes/CIP4
7 (427)	6 (446)	9 (297)	6 (340)	IPR001012: UBX
43 (61)	37 (64)	38 (52)	33 (44)	IPR005821: Ion transport protein	Molecular Function: ion channel activity (GO:0005216), Biological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020)