Top 500 InterPro hits

statistically significant differences are marked in bold (p-value of chi-square test < 0.01 without correction for multiple tests).
Aedes aegypti
15419 total genes
( 70% w domains)
Anopheles gambiae
13277 total genes
( 68% w domains)
Drosophila melanogaster
13450 total genes
( 67% w domains)
Apis mellifera
10157 total genes
( 70% w domains)
FamilyGO terms
243 (4)69 (32)89 (17)26 (61)IPR012934: Zinc finger, AD-type
663 (1)335 (1)314 (1)247 (1)IPR007087: Zinc finger, C2H2-typeMolecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270)
168 (11)40 (56)86 (18)47 (36)IPR001128: Cytochrome P450Molecular Function: monooxygenase activity (GO:0004497), Molecular Function: iron ion binding (GO:0005506), Biological Process: electron transport (GO:0006118), Molecular Function: heme binding (GO:0020037)
26 (108) () () ()IPR000448: Rhabdovirus nucleocapsid proteinCellular Component: viral nucleocapsid (GO:0019013)
41 (66)6 (484)3 (834)4 (567)IPR005055: Insect pheromone-binding protein A10/OS-D
191 (8)98 (17)89 (16)69 (24)IPR003656: Zinc finger, BED-type predictedMolecular Function: DNA binding (GO:0003677)
47 (58)11 (269)6 (473)7 (325)IPR006612: Zinc finger, C2CH-typeMolecular Function: nucleic acid binding (GO:0003676)
233 (6)128 (10)100 (13)31 (46)IPR000618: Insect cuticle proteinMolecular Function: structural constituent of cuticle (GO:0042302)
499 (2)325 (2) () ()IPR000694: Proline-rich region
24 (131)3 (878)4 (695)2 (1155)IPR007588: Zinc finger, FLYWCH-type
18 (193)2 (1300)4 (709)6 (394)IPR010629: Insect allergen related
24 (127)44 (51)17 (148)17 (112)IPR002126: CadherinMolecular Function: calcium ion binding (GO:0005509), Biological Process: homophilic cell adhesion (GO:0007156), Cellular Component: membrane (GO:0016020)
56 (49)79 (25)61 (33)83 (15)IPR004117: Olfactory receptor, DrosophilaMolecular Function: olfactory receptor activity (GO:0004984), Molecular Function: odorant binding (GO:0005549), Biological Process: perception of smell (GO:0007608), Cellular Component: membrane (GO:0016020)
27 (106)8 (337)17 (147)8 (248)IPR000637: HMG-I and HMG-Y, DNA-binding
30 (93)11 (264)18 (139)4 (537)IPR002656: Acyltransferase 3Molecular Function: transferase activity, transferring groups other than amino-acyl groups (GO:0016747)
34 (80)50 (44)14 (205)2 (953)IPR002181: Fibrinogen, alpha/beta/gamma chain, C-terminal globular
31 (91)12 (247)22 (109)4 (586)IPR006693: AB-hydrolase associated lipase regionBiological Process: lipid metabolism (GO:0006629), Molecular Function: carboxylic ester hydrolase activity (GO:0016789)
128 (18)79 (24)81 (21)38 (42)IPR002557: Chitin binding Peritrophin-ACellular Component: extracellular region (GO:0005576), Biological Process: chitin metabolism (GO:0006030), Molecular Function: chitin binding (GO:0008061)
9 (367)1 (1837)1 (1833) ()IPR005195: Glycoside hydrolase family 65, central catalytic
11 (314)2 (1265)3 (902)5 (469)IPR008273: Cellular retinaldehyde-binding/triple function, N-terminal
22 (142)8 (350)10 (270)9 (229)IPR002068: Heat shock protein Hsp20
20 (163)7 (394)2 (1033)5 (427)IPR002119: Histone H2ACellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
47 (55)25 (90)32 (61)14 (144)IPR000734: LipaseMolecular Function: catalytic activity (GO:0003824), Biological Process: lipid metabolism (GO:0006629)
64 (42)37 (65)12 (241)20 (90)IPR007125: Histone coreMolecular Function: DNA binding (GO:0003677)
62 (43)74 (30)61 (34)57 (30)IPR006210: Type I EGF
13 (272)4 (691)5 (568)2 (1173)IPR008274: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin bindingBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
11 (307)3 (816)20 (126)5 (445)IPR004210: BESS motifMolecular Function: DNA binding (GO:0003677)
146 (13)155 (8)121 (8)120 (4)IPR003599: Immunoglobulin subtype
9 (353)16 (173) () ()IPR001309: Caspase, p20 subunitBiological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
155 (12)163 (6)102 (12)97 (12)IPR007110: Immunoglobulin-like
190 (9)134 (9) () ()IPR000379: Esterase/lipase/thioesteraseMolecular Function: catalytic activity (GO:0003824)
19 (177)27 (83)10 (269)9 (228)IPR002007: Animal haem peroxidaseMolecular Function: peroxidase activity (GO:0004601)
25 (118)12 (245)14 (207)7 (321)IPR006047: Alpha amylase, catalytic regionMolecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
7 (437)13 (219)6 (432)3 (669)IPR001599: Alpha-2-macroglobulinMolecular Function: endopeptidase inhibitor activity (GO:0004866)
48 (52)28 (76)40 (48)15 (126)IPR000073: Alpha/beta hydrolase fold
9 (378)15 (196)7 (404)4 (605)IPR011600: Peptidase C14, caspase catalytic subunit p20Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
36 (76)20 (129)15 (193)5 (456)IPR006026: Peptidase, metallopeptidasesBiological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237)
13 (263)5 (542)5 (521)1 (1490)IPR002346: Molybdopterin dehydrogenase, FAD-bindingBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
13 (253)5 (511)5 (496)1 (1299)IPR000674: Aldehyde oxidase and xanthine dehydrogenase, a/b hammerheadBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
13 (264)5 (549)5 (528)1 (1557)IPR002888: [2Fe-2S]-binding
73 (34)47 (47) () ()IPR007124: Histone-fold/TFIID-TAF/NF-YMolecular Function: DNA binding (GO:0003677)
48 (54)29 (73)35 (55)10 (205)IPR001304: C-type lectinMolecular Function: sugar binding (GO:0005529)
12 (288)18 (146)17 (150)9 (238)IPR006076: FAD dependent oxidoreductaseBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (356)3 (758)3 (771)2 (932)IPR001813: Ribosomal protein 60SMolecular Function: structural constituent of ribosome (GO:0003735), Cellular Component: intracellular (GO:0005622), Cellular Component: ribosome (GO:0005840), Biological Process: translational elongation (GO:0006414)
9 (346)3 (704)3 (727)3 (609)IPR000101: Gamma-glutamyltranspeptidaseMolecular Function: gamma-glutamyltransferase activity (GO:0003840)
7 (468)12 (251)6 (480)2 (1215)IPR011626: A-macroglobulin complement component
46 (60)53 (42)24 (98)24 (66)IPR001878: Zinc finger, CCHC-typeMolecular Function: nucleic acid binding (GO:0003676)
39 (71)23 (98)28 (74)15 (129)IPR000873: AMP-dependent synthetase and ligaseMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
7 (442)2 (1059)1 (1612)1 (1514)IPR002670: Ribosomal L18ae proteinMolecular Function: structural constituent of ribosome (GO:0003735), Cellular Component: intracellular (GO:0005622), Cellular Component: ribosome (GO:0005840), Biological Process: protein biosynthesis (GO:0006412)
7 (467)2 (1281) () ()IPR009040: Ferritin-like
7 (426)2 (969)5 (501) ()IPR000875: CecropinCellular Component: extracellular region (GO:0005576), Biological Process: antibacterial humoral response (sensu Protostomia) (GO:0006961)
7 (465)2 (1266)3 (903)2 (1174)IPR008331: Ferritin and DpsBiological Process: iron ion homeostasis (GO:0006879), Molecular Function: ferric iron binding (GO:0008199)
17 (201)8 (364)15 (194)6 (387)IPR006621: Nose resistant to fluoxetine-4, N-terminal
20 (164)10 (286)7 (381)4 (551)IPR003172: E1 protein and Def2/Der2 allergen
20 (169)10 (294)13 (220)5 (461)IPR006589: Alpha amylase, catalytic subdomainMolecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
18 (194)24 (97)17 (156)20 (92)IPR012680: Laminin G, subdomain 2
9 (358)14 (205) () ()IPR002138: Peptidase C14, caspase non-catalytic subunit p10Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: caspase activity (GO:0030693)
12 (287)5 (561)5 (551)1 (1754)IPR005107: CO dehydrogenase flavoprotein, C-terminal
12 (290)5 (585)6 (479)5 (472)IPR010625: CHCH
26 (112)32 (70)16 (170)17 (113)IPR002893: Zinc finger, MYND-type
10 (340)4 (676)3 (853)3 (761)IPR006115: 6-phosphogluconate dehydrogenase, NAD-bindingMolecular Function: phosphogluconate dehydrogenase (decarboxylating) activity (GO:0004616), Biological Process: pentose-phosphate shunt (GO:0006098)
28 (102)16 (174) () ()IPR001311: Solute-binding protein/glutamate receptorMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810)
25 (117)14 (208)15 (191)7 (314)IPR004262: Male sterility protein
87 (28)91 (19)71 (27)55 (31)IPR000276: Rhodopsin-like GPCR superfamilyMolecular Function: rhodopsin-like receptor activity (GO:0001584), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Cellular Component: integral to membrane (GO:0016021)
32 (85)19 (133)25 (91)7 (301)IPR001873: Na+ channel, amiloride-sensitiveMolecular Function: sodium channel activity (GO:0005272), Biological Process: sodium ion transport (GO:0006814), Cellular Component: membrane (GO:0016020)
13 (260)6 (461)4 (631)4 (532)IPR002075: Nuclear transport factor 2Cellular Component: intracellular (GO:0005622), Cellular Component: nucleus (GO:0005634), Biological Process: protein-nucleus import (GO:0006606), Molecular Function: protein transporter activity (GO:0008565)
16 (215)21 (118)16 (177)17 (116)IPR012679: Laminin G, subdomain 1
8 (386)3 (716)2 (950)2 (866)IPR000585: Hemopexin
23 (133)13 (218)7 (358)5 (413)IPR000896: Arthropod hemocyanin/insect LSPMolecular Function: oxygen transporter activity (GO:0005344), Biological Process: transport (GO:0006810)
9 (354)13 (220)12 (230)13 (157)IPR001610: PAC motifBiological Process: regulation of transcription, DNA-dependent (GO:0006355), Biological Process: signal transduction (GO:0007165)
20 (161)11 (260)12 (232)14 (145)IPR002035: von Willebrand factor, type A
38 (73)24 (94) () ()IPR001472: Bipartite nuclear localization signal
17 (198)9 (303)9 (298)4 (502)IPR001041: FerredoxinMolecular Function: electron transporter activity (GO:0005489), Molecular Function: iron ion binding (GO:0005506), Biological Process: electron transport (GO:0006118)
76 (32)53 (43)72 (26)53 (33)IPR005828: General substrate transporterMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
72 (35)75 (29)68 (29)71 (22)IPR000210: BTB/POZMolecular Function: protein binding (GO:0005515)
28 (103)17 (156)13 (212)3 (665)IPR001506: Peptidase M12A, astacinBiological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: astacin activity (GO:0008533)
21 (157)12 (250)17 (155)8 (278)IPR011022: Arrestin, C-terminal
15 (229)19 (135)22 (108)14 (147)IPR002350: Proteinase inhibitor I1, Kazal
9 (372)4 (684)7 (396)6 (389)IPR007123: Gelsolin region
9 (357)4 (629)2 (1014)2 (933)IPR001818: Peptidase M10A and M12B, matrixin and adamalysinMolecular Function: metalloendopeptidase activity (GO:0004222), Cellular Component: extracellular matrix (sensu Metazoa) (GO:0005578), Biological Process: proteolysis and peptidolysis (GO:0006508)
39 (70)43 (52)40 (47)48 (35)IPR000008: C2
40 (68)26 (87)24 (94)23 (69)IPR000626: UbiquitinBiological Process: protein modification (GO:0006464)
34 (79)38 (59)27 (78)28 (52)IPR001214: Nuclear protein SET
15 (227)8 (349)2 (1021)4 (528)IPR001951: Histone H4Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
12 (276)6 (436)6 (413)8 (246)IPR000413: Integrins alpha chainBiological Process: cell adhesion (GO:0007155), Biological Process: cell-matrix adhesion (GO:0007160), Cellular Component: integrin complex (GO:0008305)
21 (152)25 (91)18 (138)23 (72)IPR001791: Laminin G
29 (95)18 (141)23 (100)22 (75)IPR001202: WW/Rsp5/WWP
33 (83)21 (110)24 (96)18 (104)IPR000859: CUB
112 (21)111 (14)100 (14)96 (13)IPR003598: Immunoglobulin C2 type
7 (469)10 (296)6 (481)2 (1216)IPR011627: A-macroglobulin receptor
7 (450)10 (291)4 (659)3 (730)IPR004172: L27
8 (410)11 (270)10 (285)14 (149)IPR006935: Type III restriction enzyme, res subunitMolecular Function: ATP binding (GO:0005524)
27 (105)17 (152)29 (70)7 (282)IPR000215: Proteinase inhibitor I4, serpinMolecular Function: serine-type endopeptidase inhibitor activity (GO:0004867)
31 (90)20 (127)35 (57)11 (187)IPR002213: UDP-glucuronosyl/UDP-glucosyltransferaseBiological Process: metabolism (GO:0008152), Molecular Function: transferase activity, transferring hexosyl groups (GO:0016758)
70 (37)50 (45)36 (54)13 (162)IPR006170: Pheromone/general odorant binding protein, PBP/GOBPMolecular Function: odorant binding (GO:0005549), Biological Process: transport (GO:0006810)
10 (324)5 (535)6 (436)8 (258)IPR001763: Rhodanese-like
10 (331)5 (555)4 (648)4 (550)IPR003165: Stem cell self-renewal protein Piwi
58 (47)60 (36) () ()IPR000742: EGF-like, subtype 2
24 (130)15 (193)51 (42)9 (240)IPR006578: MADF
24 (129)15 (191)10 (281)5 (451)IPR005203: Hemocyanin, C-terminal
11 (298)14 (203)14 (204)12 (173)IPR001876: Zinc finger, RanBP2-type
11 (310)14 (211)16 (173)3 (777)IPR006604: Disulphide knot CLIP
29 (97)32 (69)32 (63)29 (50)IPR001881: EGF-like calcium-bindingMolecular Function: calcium ion binding (GO:0005509)
17 (195)10 (274)6 (410)11 (180)IPR000315: Zinc finger, B-boxCellular Component: intracellular (GO:0005622), Molecular Function: zinc ion binding (GO:0008270)
26 (113)29 (75)39 (51)8 (267)IPR004045: Glutathione S-transferase, N-terminal
15 (237)18 (150)19 (132)13 (165)IPR011705: BTB/Kelch-associated
21 (156)24 (95) () ()IPR005820: Cation channel, non-ligand gatedMolecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
133 (17)101 (15)119 (9)117 (5)IPR001841: Zinc finger, RING-typeCellular Component: ubiquitin ligase complex (GO:0000151), Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Molecular Function: zinc ion binding (GO:0008270), Biological Process: protein ubiquitination (GO:0016567)
18 (192)21 (115)17 (153)19 (101)IPR006670: Cyclin
14 (240)8 (338)11 (246)6 (335)IPR000668: Peptidase C1A, papainBiological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: cysteine-type peptidase activity (GO:0008234)
41 (67)43 (54)40 (50)44 (37)IPR006209: EGF-like
18 (181)11 (254)4 (578)5 (399)IPR000164: Histone H3Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
8 (381)4 (596)8 (315)10 (197)IPR000313: PWWP
8 (407)4 (670)3 (849)1 (1823)IPR006048: Alpha amylase, C-terminal all-betaMolecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975)
31 (89)21 (113)22 (107)10 (208)IPR001930: Peptidase M1, membrane alanine aminopeptidaseMolecular Function: membrane alanyl aminopeptidase activity (GO:0004179), Biological Process: proteolysis and peptidolysis (GO:0006508)
31 (88)21 (108)25 (88)25 (63)IPR000483: Cysteine-rich flanking region, C-terminal
73 (33)54 (40)56 (37)43 (38)IPR002198: Short-chain dehydrogenase/reductase SDRBiological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491)
40 (69)28 (77)28 (75)19 (95)IPR001509: NAD-dependent epimerase/dehydrataseMolecular Function: catalytic activity (GO:0003824), Biological Process: nucleotide-sugar metabolism (GO:0009225), Molecular Function: NAD binding (GO:0051287)
23 (137)15 (188)4 (643)8 (261)IPR002919: Protease inhibitor I8, cysteine-rich trypsin inhibitor-like
12 (284)7 (400)6 (454)4 (549)IPR003146: Proteinase inhibitor, carboxypeptidase propeptideMolecular Function: carboxypeptidase activity (GO:0004180), Biological Process: proteolysis and peptidolysis (GO:0006508)
12 (283)7 (397)6 (449)4 (547)IPR003100: Argonaute and Dicer protein, PAZ
12 (289)7 (424)9 (311)3 (816)IPR008914: PEBP
25 (115)27 (80)16 (166)10 (204)IPR001223: Glycoside hydrolase, family 18Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
6 (500)8 (348)13 (214)2 (939)IPR001916: Glycoside hydrolase, family 22Cellular Component: extracellular region (GO:0005576)
22 (145)24 (96)15 (196)20 (91)IPR007867: GMC oxidoreductaseMolecular Function: oxidoreductase activity, acting on CH-OH group of donors (GO:0016614), Molecular Function: FAD binding (GO:0050660)
7 (453)9 (327)9 (308)8 (274)IPR006575: RWD
7 (464)9 (329)9 (310)9 (241)IPR008145: Guanylate kinase/L-type calcium channel region
7 (423)9 (301)5 (495)6 (334)IPR000651: Guanine nucleotide exchange factor for Ras-like GTPases, N-terminalMolecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: small GTPase mediated signal transduction (GO:0007264)
16 (210)10 (280)12 (229)19 (96)IPR001609: Myosin head, motor regionMolecular Function: motor activity (GO:0003774), Molecular Function: ATP binding (GO:0005524), Cellular Component: myosin (GO:0016459)
24 (122)16 (167)34 (58)18 (102)IPR000301: CD9/CD37/CD63 antigenCellular Component: integral to membrane (GO:0016021)
20 (168)22 (106)21 (121)21 (86)IPR006202: Neurotransmitter-gated ion-channel ligand-bindingMolecular Function: extracellular ligand-gated ion channel activity (GO:0005230), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
51 (51)37 (63)42 (45)40 (39)IPR001965: Zinc finger, PHD-typeMolecular Function: protein binding (GO:0005515), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Molecular Function: zinc ion binding (GO:0008270)
9 (348)5 (505)5 (492)5 (405)IPR000462: CDP-alcohol phosphatidyltransferaseBiological Process: phospholipid biosynthesis (GO:0008654)
9 (355)5 (534)4 (627)5 (425)IPR001747: Lipid transport protein, N-terminalMolecular Function: lipid transporter activity (GO:0005319), Biological Process: lipid transport (GO:0006869)
20 (162)13 (221)7 (374)10 (209)IPR002085: Alcohol dehydrogenase superfamily, zinc-containingMolecular Function: zinc ion binding (GO:0008270), Molecular Function: oxidoreductase activity (GO:0016491)
9 (352)11 (258)6 (427)9 (224)IPR001258: NHL repeat
10 (323)12 (235) () ()IPR001601: Generic methyltransferaseMolecular Function: methyltransferase activity (GO:0008168)
10 (320)12 (232)12 (228)12 (172)IPR001357: BRCTCellular Component: intracellular (GO:0005622)
6 (474)3 (702)3 (724)3 (608)IPR000058: Zinc finger, AN1-typeMolecular Function: molecular function unknown (GO:0005554)
15 (236)17 (164)22 (110)13 (164)IPR011497: Protease inhibitor, Kazal-type
15 (234)17 (162)13 (222)15 (138)IPR006671: Cyclin, N-terminalBiological Process: regulation of progression through cell cycle (GO:0000074)
15 (216)17 (151)14 (198)11 (179)IPR000086: NUDIX hydrolase
11 (306)13 (225)16 (171)14 (148)IPR004161: Elongation factor Tu, domain 2Molecular Function: GTP binding (GO:0005525)
11 (302)13 (223)12 (236)11 (188)IPR003131: K+ channel tetramerisationMolecular Function: voltage-gated potassium channel activity (GO:0005249), Biological Process: potassium ion transport (GO:0006813), Cellular Component: voltage-gated potassium channel complex (GO:0008076), Cellular Component: membrane (GO:0016020)
14 (248)16 (179) () ()IPR006195: Aminoacyl-transfer RNA synthetase, class IIMolecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
38 (75)27 (84)26 (86)21 (83)IPR002867: Zinc finger, C6HC-type
13 (258)8 (346)13 (213)1 (1407)IPR001604: DNA/RNA non-specific endonucleaseMolecular Function: nucleic acid binding (GO:0003676), Molecular Function: endonuclease activity (GO:0004519)
13 (257)8 (345)8 (327)9 (226)IPR001496: SOCS protein, C-terminalBiological Process: intracellular signaling cascade (GO:0007242)
13 (273)8 (370)12 (242)14 (151)IPR008280: Tubulin/FtsZ, C-terminalMolecular Function: GTPase activity (GO:0003924), Molecular Function: GTP binding (GO:0005525), Cellular Component: protein complex (GO:0043234), Biological Process: protein polymerization (GO:0051258)
58 (48)43 (53)58 (35)53 (32)IPR001092: Basic helix-loop-helix dimerisation region bHLHCellular Component: nucleus (GO:0005634), Molecular Function: transcription regulator activity (GO:0030528), Biological Process: regulation of transcription (GO:0045449)
17 (196)11 (256)9 (292)11 (181)IPR000408: Regulator of chromosome condensation, RCC1
17 (200)11 (265)13 (216)10 (212)IPR002999: TudorMolecular Function: nucleic acid binding (GO:0003676)
59 (46)44 (50)35 (56)27 (56)IPR002018: Carboxylesterase, type B
10 (327)6 (467)6 (446)4 (536)IPR002645: Sulfate transporter/antisigma-factor antagonist STAS
10 (339)6 (486)6 (468)6 (384)IPR006092: Acyl-CoA dehydrogenase, N-terminalMolecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118)
10 (343)6 (493)3 (878)2 (1140)IPR007007: NinjurinBiological Process: cell adhesion (GO:0007155), Cellular Component: integral to membrane (GO:0016021), Biological Process: tissue regeneration (GO:0042246)
10 (321)6 (451)1 (1503)2 (913)IPR001360: Glycoside hydrolase, family 1Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
60 (45)45 (49)56 (39)63 (27)IPR011511: Variant SH3
28 (104)29 (74)26 (85)26 (60)IPR002219: Protein kinase C, phorbol ester/diacylglycerol bindingBiological Process: intracellular signaling cascade (GO:0007242)
18 (190)12 (242)7 (385)11 (193)IPR003958: Transcription factor CBF/NF-Y/archaeal histoneMolecular Function: DNA binding (GO:0003677)
18 (185)12 (234)15 (185)13 (156)IPR001507: Endoglin/CD105 antigen
36 (77)26 (89)29 (73)10 (218)IPR006625: Insect pheromone/odorant binding protein PhBP
65 (40)63 (34) () ()IPR001410: DEAD/DEAH box helicaseMolecular Function: ATP binding (GO:0005524), Molecular Function: ATP-dependent helicase activity (GO:0008026)
7 (425)4 (610)3 (746)3 (638)IPR000794: Beta-ketoacyl synthaseMolecular Function: catalytic activity (GO:0003824), Biological Process: fatty acid biosynthesis (GO:0006633)
7 (430)4 (617)4 (602)5 (414)IPR001117: Multicopper oxidase, type 1Molecular Function: copper ion binding (GO:0005507)
7 (462)4 (690) () ()IPR008139: Saposin B
7 (417)4 (597)3 (738)3 (615)IPR000322: Glycoside hydrolase, family 31Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
7 (470)4 (700)5 (575)5 (474)IPR011706: Multicopper oxidase, type 2Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491)
7 (461)4 (687)5 (564)3 (798)IPR007632: Protein of unknown function DUF590
7 (460)4 (683)4 (692)3 (793)IPR007122: GelsolinMolecular Function: actin binding (GO:0003779)
7 (420)4 (602)4 (584)2 (861)IPR000472: TGF-beta receptor/activin receptor, type I/IIMolecular Function: transmembrane receptor protein serine/threonine kinase activity (GO:0004675), Molecular Function: transforming growth factor beta receptor activity (GO:0005024), Cellular Component: membrane (GO:0016020)
7 (445)4 (639)5 (531)7 (307)IPR003034: DNA-binding SAPMolecular Function: DNA binding (GO:0003677)
23 (134)16 (172)22 (104)13 (154)IPR001140: ABC transporter, transmembrane regionMolecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
28 (101)20 (125)26 (82)4 (510)IPR001283: Allergen V5/Tpx-1 relatedCellular Component: extracellular region (GO:0005576)
15 (220)10 (275)20 (124)11 (183)IPR000953: ChromoCellular Component: chromatin (GO:0000785), Molecular Function: chromatin binding (GO:0003682), Cellular Component: nucleus (GO:0005634), Biological Process: chromatin assembly or disassembly (GO:0006333)
15 (228)10 (282)11 (250)9 (230)IPR002086: Aldehyde dehydrogenaseBiological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491)
11 (295)7 (378)9 (293)15 (128)IPR000560: Histidine acid phosphataseMolecular Function: acid phosphatase activity (GO:0003993)
11 (313)7 (420) () ()IPR007107: LIM homeoboxMolecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Molecular Function: zinc ion binding (GO:0008270)
11 (299)7 (395)8 (330)8 (260)IPR002165: PlexinMolecular Function: receptor activity (GO:0004872), Cellular Component: membrane (GO:0016020)
11 (297)7 (391)7 (371)6 (355)IPR001737: Ribosomal RNA adenine methylase transferaseBiological Process: rRNA modification (GO:0000154), Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179), Molecular Function: rRNA methyltransferase activity (GO:0008649)
17 (199)18 (140)18 (135)18 (106)IPR001163: Like-Sm ribonucleoprotein, coreCellular Component: nucleus (GO:0005634), Cellular Component: small nucleolar ribonucleoprotein complex (GO:0005732), Biological Process: mRNA processing (GO:0006397)
29 (98)21 (116) () ()IPR011527: ABC transporter, transmembrane region, type 1Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
15 (225)16 (177)23 (101)19 (98)IPR001828: Extracellular ligand-binding receptor
15 (217)16 (166)16 (158)15 (127)IPR000242: Tyrosine specific protein phosphataseMolecular Function: protein tyrosine phosphatase activity (GO:0004725), Biological Process: protein amino acid dephosphorylation (GO:0006470)
15 (219)16 (170)18 (134)16 (123)IPR000795: Protein synthesis factor, GTP-bindingMolecular Function: GTP binding (GO:0005525), Biological Process: protein biosynthesis (GO:0006412)
20 (171)14 (215)17 (154)7 (329)IPR011021: Arrestin, N-terminal
14 (243)15 (187)11 (249)13 (158)IPR002049: Laminin-type EGF-likeMolecular Function: structural molecule activity (GO:0005198)
14 (245)15 (189)15 (188)13 (159)IPR003595: Protein tyrosine phosphatase, catalytic regionMolecular Function: protein tyrosine phosphatase activity (GO:0004725)
14 (249)15 (194)18 (141)16 (125)IPR006594: Lissencephaly type-1-like homology motif
14 (239)15 (181)9 (291)4 (481)IPR000157: TIRMolecular Function: transmembrane receptor activity (GO:0004888), Cellular Component: membrane (GO:0016020)
14 (241)15 (184)16 (163)21 (81)IPR000884: Thrombospondin, type I
13 (255)14 (200)13 (210)12 (170)IPR001159: Double-stranded RNA bindingMolecular Function: double-stranded RNA binding (GO:0003725), Cellular Component: intracellular (GO:0005622)
13 (256)14 (201)11 (248)9 (225)IPR001395: Aldo/keto reductaseMolecular Function: oxidoreductase activity (GO:0016491)
13 (259)14 (202) () ()IPR001682: Ca2+/Na+ channel, pore regionMolecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
13 (261)14 (204)10 (271)12 (174)IPR002123: Phospholipid/glycerol acyltransferaseBiological Process: metabolism (GO:0008152), Molecular Function: acyltransferase activity (GO:0008415)
30 (92)22 (102) () ()IPR000205: NAD-binding site
8 (388)5 (512)6 (417)7 (287)IPR000679: Zinc finger, GATA-typeMolecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
8 (401)5 (544)5 (525)5 (433)IPR002562: 3'-5' exonucleaseMolecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622), Molecular Function: 3'-5' exonuclease activity (GO:0008408)
8 (384)5 (506) () ()IPR000513: 5'3'-Exonuclease N- and I-domainMolecular Function: DNA binding (GO:0003677), Molecular Function: nuclease activity (GO:0004518)
8 (396)5 (531)5 (510)3 (662)IPR001424: Superoxide dismutase, copper/zinc bindingMolecular Function: copper, zinc superoxide dismutase activity (GO:0004785), Biological Process: superoxide metabolism (GO:0006801), Molecular Function: metal ion binding (GO:0046872)
10 (345)11 (271)9 (312)9 (243)IPR011547: Sulphate transporterMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
41 (65)40 (58)41 (46)39 (41)IPR003959: AAA ATPase, central regionMolecular Function: ATP binding (GO:0005524)
21 (155)15 (192)8 (343)5 (452)IPR005204: Hemocyanin, N-terminal
8 (409)9 (325)17 (151)7 (322)IPR006186: Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphataseMolecular Function: hydrolase activity (GO:0016787)
8 (404)9 (321)11 (255)11 (194)IPR004344: Tubulin-tyrosine ligaseMolecular Function: tubulin-tyrosine ligase activity (GO:0004835), Biological Process: protein modification (GO:0006464)
8 (383)9 (297)10 (263)10 (198)IPR000337: GPCR, family 3, metabotropic glutamate receptor-likeMolecular Function: metabotropic glutamate, GABA-B-like receptor activity (GO:0008067), Cellular Component: membrane (GO:0016020)
8 (397)9 (309)6 (431)10 (206)IPR001590: Peptidase M12B, ADAM/reprolysinMolecular Function: metalloendopeptidase activity (GO:0004222), Biological Process: proteolysis and peptidolysis (GO:0006508)
27 (107)27 (82)27 (79)25 (64)IPR001715: Calponin-like actin-binding
7 (435)8 (344)7 (369)4 (518)IPR001464: AnnexinMolecular Function: calcium ion binding (GO:0005509), Molecular Function: calcium-dependent phospholipid binding (GO:0005544)
7 (438)8 (347)6 (434)5 (424)IPR001627: Semaphorin/CD100 antigen
7 (466)8 (373) () ()IPR009038: GOLD
7 (463)8 (369)7 (398)7 (327)IPR008144: Guanylate kinase
7 (432)8 (342)6 (426)7 (296)IPR001247: 3' exoribonucleaseMolecular Function: 3'-5'-exoribonuclease activity (GO:0000175), Molecular Function: RNA binding (GO:0003723), Biological Process: RNA processing (GO:0006396)
6 (493)7 (390)7 (366)6 (347)IPR001345: Phosphoglycerate/bisphosphoglycerate mutaseMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
6 (488)7 (381)7 (360)4 (500)IPR000990: InnexinCellular Component: gap junction (GO:0005921)
6 (498)7 (392)5 (515)6 (356)IPR001762: Disintegrin
6 (492)7 (388)8 (324)6 (345)IPR001279: Beta-lactamase-like
6 (490)7 (383)6 (421)7 (292)IPR001025: Bromo adjacent regionMolecular Function: DNA binding (GO:0003677)
6 (484)7 (380)9 (295)7 (290)IPR000866: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
24 (124)24 (93)18 (133)19 (94)IPR000595: Cyclic nucleotide-binding
23 (135)23 (99)22 (106)22 (76)IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2Molecular Function: cysteine-type endopeptidase activity (GO:0004197), Molecular Function: ubiquitin thiolesterase activity (GO:0004221), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511)
13 (268)9 (323)11 (256)10 (217)IPR006020: Phosphotyrosine interaction region
13 (252)9 (298)14 (199)12 (169)IPR000433: Zinc finger, ZZ-typeMolecular Function: zinc ion binding (GO:0008270)
123 (19)99 (16)130 (5)98 (10)IPR011701: Major facilitator superfamily MFS_1
22 (140)22 (101)21 (114)21 (79)IPR000195: RabGAP/TBC
22 (144)22 (105)32 (64)6 (378)IPR004046: Glutathione S-transferase, C-terminal
22 (139)22 (100)15 (178)20 (87)IPR000172: Glucose-methanol-choline oxidoreductaseBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (375)6 (495)4 (698)4 (592)IPR008011: Complex 1 LYR proteinCellular Component: mitochondrial inner membrane (GO:0005743), Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity, acting on NADH or NADPH (GO:0016651)
9 (349)6 (438)7 (356)6 (333)IPR000577: Carbohydrate kinase, FGGYBiological Process: carbohydrate metabolism (GO:0005975)
9 (374)6 (494)9 (309)7 (326)IPR007889: Helix-turn-helix, PsqMolecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
9 (364)6 (477)8 (337)8 (266)IPR003903: Ubiquitin interacting motif
21 (159)21 (117)20 (130)13 (166)IPR012464: Protein of unknown function DUF1676
94 (24)87 (22)99 (15)89 (14)IPR001356: HomeoboxMolecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
18 (188)13 (222)16 (168)15 (133)IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin typeBiological Process: protein folding (GO:0006457)
28 (100)21 (109)24 (93)26 (57)IPR000571: Zinc finger, CCCH-typeMolecular Function: nucleic acid binding (GO:0003676)
23 (138)17 (159)28 (76)21 (84)IPR004088: KH, type 1Molecular Function: nucleic acid binding (GO:0003676)
23 (136)17 (158)20 (125)14 (146)IPR002076: GNS1/SUR4 membrane proteinCellular Component: integral to membrane (GO:0016021)
23 (132)17 (154)15 (180)16 (120)IPR000372: Cysteine-rich flanking region, N-terminal
19 (176)19 (131)16 (161)18 (103)IPR000536: Nuclear hormone receptor, ligand-bindingMolecular Function: transcription factor activity (GO:0003700), Molecular Function: steroid hormone receptor activity (GO:0003707), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
42 (63)40 (57)43 (44)33 (43)IPR002172: Low density lipoprotein-receptor, class A
18 (189)18 (144)17 (149)17 (114)IPR002917: GTP-binding protein, HSR1-related
236 (5)212 (4)207 (3)201 (2)IPR000719: Protein kinaseMolecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
24 (128)18 (145)29 (72)23 (73)IPR004087: KHMolecular Function: nucleic acid binding (GO:0003676)
19 (175)14 (198)16 (159)11 (182)IPR000436: Sushi/SCR/CCP
19 (178)14 (207)15 (189)15 (135)IPR004000: Actin/actin-likeMolecular Function: protein binding (GO:0005515)
51 (50)48 (46)55 (40)51 (34)IPR001806: Ras GTPaseMolecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264)
369 (3)307 (3)243 (2)58 (28)IPR001254: Peptidase S1 and S6, chymotrypsin/HapMolecular Function: trypsin activity (GO:0004295), Biological Process: proteolysis and peptidolysis (GO:0006508)
88 (27)81 (23)76 (23)74 (19)IPR001650: Helicase, C-terminalMolecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524)
16 (211)16 (176)16 (167)9 (227)IPR001734: Na+/solute symporterMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
16 (214)16 (180)19 (131)17 (115)IPR006662: Thioredoxin-relatedMolecular Function: electron transporter activity (GO:0005489), Biological Process: electron transport (GO:0006118)
16 (206)16 (169)14 (201)16 (122)IPR000717: Proteasome component region PCI
16 (203)16 (165)16 (157)13 (153)IPR000014: PASMolecular Function: signal transducer activity (GO:0004871), Biological Process: signal transduction (GO:0007165)
16 (205)16 (168)12 (225)16 (118)IPR000306: Zinc finger, FYVE-typeMolecular Function: zinc ion binding (GO:0008270)
10 (337)7 (410)7 (392)7 (320)IPR005817: Wnt superfamilyMolecular Function: signal transducer activity (GO:0004871), Cellular Component: extracellular region (GO:0005576), Biological Process: frizzled-2 signaling pathway (GO:0007223), Biological Process: development (GO:0007275)
10 (341)7 (416)1 (1887)1 (1839)IPR006163: Phosphopantetheine-bindingMolecular Function: cofactor binding (GO:0048037)
25 (116)19 (134) () ()IPR002293: Amino acid/polyamine transporter IMolecular Function: amino acid-polyamine transporter activity (GO:0005279), Biological Process: amino acid transport (GO:0006865), Cellular Component: membrane (GO:0016020)
112 (20)91 (20)82 (20)97 (11)IPR002110: Ankyrin
15 (233)15 (195)20 (129)8 (275)IPR006631: Protein of unknown function DM4/12
15 (221)15 (185)26 (83)13 (155)IPR001353: 20S proteasome, A and B subunitsMolecular Function: threonine endopeptidase activity (GO:0004298), Cellular Component: proteasome core complex (sensu Eukaryota) (GO:0005839), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511)
48 (53)45 (48)30 (68)20 (88)IPR001251: Cellular retinaldehyde-binding/triple function, C-terminal
15 (223)11 (259)21 (117)11 (185)IPR001594: Zinc finger, DHHC-typeMolecular Function: metal ion binding (GO:0046872)
20 (165)15 (190)15 (192)15 (137)IPR004841: Amino acid permease-associated regionBiological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
6 (482)4 (608)3 (743)3 (631)IPR000716: Thyroglobulin type-1
6 (491)4 (616)3 (751)3 (646)IPR001026: Epsin, N-terminal
14 (247)14 (209)10 (283)8 (270)IPR006090: Acyl-CoA dehydrogenase, C-terminalBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
26 (109)20 (123)24 (95)10 (201)IPR000834: Peptidase M14, carboxypeptidase AMolecular Function: carboxypeptidase A activity (GO:0004182), Biological Process: proteolysis and peptidolysis (GO:0006508)
12 (281)12 (238)12 (233)9 (231)IPR002159: CD36 antigenBiological Process: cell adhesion (GO:0007155), Cellular Component: membrane (GO:0016020)
12 (275)12 (227)11 (245)12 (168)IPR000403: Phosphatidylinositol 3- and 4-kinase, catalyticMolecular Function: phosphotransferase activity, alcohol group as acceptor (GO:0016773)
11 (308)8 (362)21 (119)7 (318)IPR005123: 2OG-Fe(II) oxygenase
11 (294)8 (336)1 (1423)4 (491)IPR000558: Histone H2BCellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001)
11 (312)8 (366) () ()IPR007104: Paired-like homeoboxMolecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
11 (315)8 (372)6 (478)3 (814)IPR008758: Peptidase S28Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: serine-type peptidase activity (GO:0008236)
16 (209)12 (231)16 (165)12 (171)IPR001199: Cytochrome b5
16 (208)12 (228)14 (202)6 (336)IPR000772: Ricin B lectin
11 (309)11 (267)12 (240)10 (216)IPR005135: Endonuclease/exonuclease/phosphatase
11 (301)11 (262)13 (215)10 (211)IPR002423: Chaperonin Cpn60/TCP-1Molecular Function: protein binding (GO:0005515), Molecular Function: ATP binding (GO:0005524), Biological Process: cellular protein metabolism (GO:0044267)
11 (296)11 (257)8 (320)9 (221)IPR000594: UBA/THIF-type NAD/FAD binding foldMolecular Function: catalytic activity (GO:0003824)
11 (292)11 (253)10 (261)7 (279)IPR000033: Low-density lipoprotein receptor, YWTD repeatCellular Component: membrane (GO:0016020)
87 (29)79 (26)74 (25)78 (17)IPR011545: DEAD/DEAH box helicase, N-terminalMolecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524)
33 (82)26 (86)31 (66)28 (51)IPR000048: IQ calmodulin-binding region
22 (141)21 (112)21 (118)21 (82)IPR001628: Nuclear hormone receptor, DNA-bindingMolecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
22 (143)21 (114) () ()IPR002111: Cation (not K+) channel, TM regionMolecular Function: cation channel activity (GO:0005261), Biological Process: cation transport (GO:0006812), Cellular Component: membrane (GO:0016020)
10 (336)10 (293)8 (341)7 (317)IPR005018: DOMONMolecular Function: dopamine beta-monooxygenase activity (GO:0004500), Biological Process: catecholamine metabolism (GO:0006584)
10 (332)10 (288)7 (383)8 (264)IPR003594: ATP-binding region, ATPase-likeMolecular Function: ATP binding (GO:0005524)
10 (325)10 (281)8 (329)7 (302)IPR001895: Guanine-nucleotide dissociation stimulator CDC25Molecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: intracellular signaling cascade (GO:0007242)
60 (44)55 (39)56 (36)67 (25)IPR000357: HEAT
77 (30)70 (31)67 (30)78 (16)IPR001849: Pleckstrin-like
21 (147)20 (122)22 (102)10 (200)IPR000832: GPCR, family 2, secretin-likeMolecular Function: G-protein coupled receptor activity (GO:0004930), Cellular Component: membrane (GO:0016020)
21 (149)20 (124)16 (164)10 (203)IPR001173: Glycosyl transferase, family 2
21 (154)20 (128)30 (69)22 (77)IPR003579: Ras small GTPase, Rab typeMolecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264), Biological Process: protein transport (GO:0015031)
17 (197)13 (216)16 (160)16 (121)IPR000467: D111/G-patchMolecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622)
31 (87)29 (72) () ()IPR000387: Tyrosine specific protein phosphatase and dual specificity protein phosphataseMolecular Function: phosphoprotein phosphatase activity (GO:0004721), Biological Process: protein amino acid dephosphorylation (GO:0006470)
7 (440)5 (539) () ()IPR001870: B302, (SPRY)-like
7 (456)5 (570)8 (347)3 (779)IPR006616: Protein of unknown function DM9
7 (459)5 (571)5 (559)5 (463)IPR006630: RNA-binding protein Lupus La
7 (421)5 (509)2 (949)5 (407)IPR000566: Lipocalin-related protein and Bos/Can/Equ allergenMolecular Function: binding (GO:0005488)
7 (439)5 (538)5 (517)6 (357)IPR001846: von Willebrand factor, type D
7 (424)5 (513) () ()IPR000690: Zinc finger, C2H2-type matrinMolecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634)
7 (471)5 (590)4 (718)5 (475)IPR011707: Multicopper oxidase, type 3Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491)
9 (377)9 (331)7 (401)2 (1186)IPR009318: Trehalose receptor
9 (360)9 (313) () ()IPR002341: HSF/ETS, DNA-bindingMolecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
76 (31)62 (35)71 (28)73 (20)IPR001452: SH3
12 (278)9 (304)6 (422)2 (892)IPR001079: Galectin, galactose-binding lectinMolecular Function: sugar binding (GO:0005529)
12 (280)9 (311)12 (231)3 (676)IPR001952: Alkaline phosphataseBiological Process: metabolism (GO:0008152)
12 (279)9 (310)14 (203)10 (207)IPR001753: Enoyl-CoA hydratase/isomeraseMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
20 (167)19 (136)21 (120)21 (85)IPR006029: Neurotransmitter-gated ion-channel transmembrane regionBiological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020), Molecular Function: neurotransmitter receptor activity (GO:0030594)
20 (172)19 (138)18 (143)18 (110)IPR011700: Basic leucine zipperMolecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
8 (389)8 (339) () ()IPR000731: Sterol-sensing 5TM box
8 (415)8 (374) () ()IPR013017: NHL
8 (398)8 (351)6 (441)8 (259)IPR002073: 3'5'-cyclic nucleotide phosphodiesteraseMolecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114), Biological Process: signal transduction (GO:0007165)
8 (405)8 (361)7 (390)7 (315)IPR004365: nucleic acid binding, OB-fold, tRNA/helicase-typeMolecular Function: nucleic acid binding (GO:0003676)
8 (411)8 (367)10 (286)6 (390)IPR007248: Mpv17/PMP22Cellular Component: integral to membrane (GO:0016021)
29 (94)27 (79)32 (60)27 (54)IPR000608: Ubiquitin-conjugating enzyme, E2Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512), Molecular Function: ubiquitin-like activating enzyme activity (GO:0008642)
19 (180)18 (148)16 (175)18 (109)IPR011498: Kelch
19 (174)18 (139)17 (145)16 (119)IPR000330: SNF2-relatedMolecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524)
135 (16)112 (13)122 (7)116 (6)IPR003593: AAA ATPaseMolecular Function: nucleotide binding (GO:0000166), Molecular Function: nucleoside-triphosphatase activity (GO:0017111)
47 (57)38 (62)54 (41)13 (160)IPR004119: Protein of unknown function DUF227Molecular Function: molecular function unknown (GO:0005554)
47 (56)38 (61)36 (53)28 (53)IPR001810: Cyclin-like F-box
7 (451)7 (412)8 (344)8 (268)IPR005824: KOW
7 (441)7 (396)7 (376)7 (304)IPR002553: Adaptin, N-terminal
7 (447)7 (404)12 (238)6 (373)IPR003650: OrangeMolecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
7 (429)7 (384)6 (423)7 (294)IPR001093: IMP dehydrogenase/GMP reductaseMolecular Function: catalytic activity (GO:0003824)
7 (472)7 (428)6 (482)5 (476)IPR011765: Peptidase M16, N-terminal
7 (418)7 (376)10 (264)6 (331)IPR000348: emp24/gp25L/p24Biological Process: intracellular protein transport (GO:0006886), Molecular Function: protein carrier activity (GO:0008320), Cellular Component: membrane (GO:0016020)
7 (433)7 (389)4 (614)3 (657)IPR001310: Histidine triad (HIT) protein
7 (454)7 (418)8 (345)7 (324)IPR006595: CTLH, C-terminal to LisH motif
7 (452)7 (417)6 (472)9 (239)IPR006560: AWS
7 (431)7 (386) () ()IPR001201: PAP/25A coreMolecular Function: nucleic acid binding (GO:0003676)
7 (416)7 (375)6 (407)5 (397)IPR000095: PAK-box/P21-Rho-binding
7 (457)7 (419)11 (259)4 (585)IPR006619: Animal peptidoglycan recognition protein PGRPMolecular Function: protein binding (GO:0005515)
46 (59)42 (55) () ()IPR000051: SAM (and some other nucleotide) binding motifMolecular Function: S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)
24 (123)19 (130)26 (81)19 (93)IPR000449: Ubiquitin-associated
18 (187)17 (157)9 (300)15 (132)IPR002017: Spectrin repeat
13 (265)10 (284)12 (235)15 (134)IPR003008: Tubulin/FtsZ, GTPase
6 (483)6 (443)2 (963)1 (1310)IPR000757: Glycoside hydrolase, family 16Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975)
6 (480)6 (434)4 (583)5 (402)IPR000331: Rap/ran-GAP
6 (479)6 (432)4 (582)4 (486)IPR000323: Copper type II, ascorbate-dependent monooxygenaseMolecular Function: monooxygenase activity (GO:0004497), Molecular Function: copper ion binding (GO:0005507)
6 (473)6 (429)4 (576)5 (396)IPR000034: Laminin B
6 (485)6 (444)6 (419)6 (338)IPR000904: SEC7-like
6 (499)6 (460)7 (373)4 (526)IPR001879: Hormone receptor, extracellularMolecular Function: G-protein coupled receptor activity (GO:0004930), Cellular Component: membrane (GO:0016020)
6 (475)6 (431)6 (408)4 (480)IPR000120: AmidaseMolecular Function: amidase activity (GO:0004040)
6 (497)6 (456)4 (623)3 (668)IPR001597: Aromatic amino acid beta-eliminating lyase/threonine aldolaseBiological Process: amino acid metabolism (GO:0006520), Molecular Function: lyase activity (GO:0016829)
6 (481)6 (439)6 (415)5 (408)IPR000591: Pleckstrin/ G-protein, interacting regionBiological Process: intracellular signaling cascade (GO:0007242)
6 (487)6 (445)7 (359)7 (291)IPR000938: CAP-Gly
8 (395)6 (453)7 (368)7 (297)IPR001375: Peptidase S9, prolyl oligopeptidase active site regionBiological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: serine-type peptidase activity (GO:0008236)
8 (393)6 (449)4 (611)5 (417)IPR001298: Filamin/ABP280 repeat
8 (400)6 (465)7 (375)6 (360)IPR002524: Cation efflux proteinBiological Process: cation transport (GO:0006812), Molecular Function: cation transporter activity (GO:0008324), Cellular Component: membrane (GO:0016020)
8 (402)6 (472)7 (380)7 (308)IPR003107: RNA-processing protein, HAT helixCellular Component: intracellular (GO:0005622), Biological Process: RNA processing (GO:0006396)
8 (387)6 (441)5 (494)7 (286)IPR000644: CBS
8 (406)6 (482)6 (462)6 (380)IPR004367: Cyclin, C-terminalBiological Process: regulation of progression through cell cycle (GO:0000074), Cellular Component: nucleus (GO:0005634)
8 (382)6 (433)10 (262)5 (401)IPR000326: Phosphoesterase, PA-phosphatase related
8 (394)6 (452)7 (367)6 (348)IPR001373: CullinBiological Process: cell cycle (GO:0007049)
8 (380)6 (430)6 (406)7 (281)IPR000089: Biotin/lipoyl attachment
8 (385)6 (437)5 (493)3 (621)IPR000539: Frizzled proteinMolecular Function: non-G-protein coupled 7TM receptor activity (GO:0004926), Biological Process: cell surface receptor linked signal transduction (GO:0007166), Cellular Component: membrane (GO:0016020)
93 (25)77 (27)76 (22)75 (18)IPR001440: TPR repeat
19 (173)15 (182)17 (144)21 (80)IPR000225: Armadillo
25 (114)20 (120)21 (113)17 (111)IPR000182: GCN5-related N-acetyltransferaseMolecular Function: N-acetyltransferase activity (GO:0008080)
42 (62)38 (60) () ()IPR001622: K+ channel, pore regionMolecular Function: potassium channel activity (GO:0005267), Biological Process: potassium ion transport (GO:0006813), Cellular Component: membrane (GO:0016020)
67 (39)60 (37)61 (32)58 (29)IPR003961: Fibronectin, type III
26 (110)21 (111)22 (103)23 (70)IPR000910: HMG1/2 (high mobility group) boxMolecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
15 (218)14 (199)14 (200)14 (143)IPR000569: HECTMolecular Function: ubiquitin-protein ligase activity (GO:0004842), Cellular Component: intracellular (GO:0005622), Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512)
15 (231)14 (210)13 (219)8 (271)IPR006091: Acyl-CoA dehydrogenase, central regionMolecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118)
15 (235)14 (214)14 (208)14 (150)IPR007502: Helicase-associated regionMolecular Function: helicase activity (GO:0004386)
24 (125)22 (104)25 (90)18 (105)IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclaseBiological Process: intracellular signaling cascade (GO:0007242), Biological Process: cyclic nucleotide biosynthesis (GO:0009190), Molecular Function: phosphorus-oxygen lyase activity (GO:0016849)
64 (41)53 (41) () ()IPR001687: ATP/GTP-binding site motif A (P-loop)Molecular Function: ATP binding (GO:0005524)
9 (365)7 (406)6 (461)6 (377)IPR004038: Ribosomal protein L7Ae/L30e/S12e/Gadd45
9 (350)7 (385)11 (247)8 (252)IPR001107: Band 7 protein
9 (366)7 (409)8 (342)6 (381)IPR005024: Snf7Molecular Function: molecular function unknown (GO:0005554)
9 (369)7 (414)2 (1201)1 (1828)IPR006088: Sterol desaturaseMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
9 (379)7 (426)9 (313)12 (178)IPR011704: ATPase associated with various cellular activities, AAA_5Molecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887)
9 (368)7 (411)3 (846)4 (573)IPR005818: Histone H1/H5Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334)
14 (244)13 (224)13 (218)24 (67)IPR003534: Major royal jelly protein
15 (232)12 (246)13 (221)1 (1851)IPR006593: Cytochrome b561 / ferric reductase transmembrane
15 (230)12 (239)8 (334)6 (366)IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferaseBiological Process: nitrogen compound metabolism (GO:0006807), Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)
15 (226)12 (237)15 (187)11 (186)IPR001932: Protein phosphatase 2C-likeMolecular Function: catalytic activity (GO:0003824)
15 (222)12 (233)15 (184)8 (256)IPR001494: Importin-beta, N-terminalBiological Process: protein-nucleus import, docking (GO:0000059), Cellular Component: nucleus (GO:0005634), Cellular Component: nuclear pore (GO:0005643), Cellular Component: cytoplasm (GO:0005737), Molecular Function: protein transporter activity (GO:0008565)
15 (224)12 (236)8 (328)6 (353)IPR001699: Transcription factor, T-boxMolecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
15 (238)12 (252)13 (224)11 (196)IPR011709: Protein of unknown function DUF1605Molecular Function: ATP binding (GO:0005524), Molecular Function: ATP-dependent helicase activity (GO:0008026)
21 (148)17 (155)24 (97)24 (65)IPR001005: Myb, DNA-bindingMolecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634)
72 (36)64 (33)63 (31)66 (26)IPR001478: PDZ/DHR/GLGFMolecular Function: protein binding (GO:0005515)
34 (81)28 (78)32 (65)19 (99)IPR004843: MetallophosphoesteraseMolecular Function: hydrolase activity (GO:0016787)
13 (266)12 (240)12 (237)11 (191)IPR003604: Zinc finger, U1-typeMolecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270)
13 (271)12 (249)15 (197)9 (242)IPR008191: Maternal tudor protein
13 (270)12 (248) () ()IPR007092: Leucine-rich repeat, SDS22+-like
13 (250)12 (226)12 (226)12 (167)IPR000340: Dual specificity protein phosphataseBiological Process: protein amino acid dephosphorylation (GO:0006470), Molecular Function: protein tyrosine/serine/threonine phosphatase activity (GO:0008138)
13 (254)12 (230)15 (183)10 (202)IPR001148: Carbonic anhydrase, eukaryoticMolecular Function: carbonate dehydratase activity (GO:0004089), Biological Process: one-carbon compound metabolism (GO:0006730), Molecular Function: zinc ion binding (GO:0008270)
13 (267)12 (244)10 (282)9 (237)IPR005804: Fatty acid desaturaseMolecular Function: oxidoreductase activity (GO:0016491)
21 (151)19 (132)18 (137)15 (131)IPR001766: Fork head transcription factorMolecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
16 (207)13 (217)12 (227)9 (222)IPR000727: Target SNARE coiled-coil region
10 (322)8 (343)6 (429)6 (350)IPR001433: Oxidoreductase FAD/NAD(P)-bindingBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
10 (326)8 (352)8 (331)9 (232)IPR002300: Aminoacyl-tRNA synthetase, class IaMolecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
10 (330)8 (356)9 (304)5 (436)IPR002939: Chaperone DnaJ, C-terminalBiological Process: protein folding (GO:0006457), Molecular Function: unfolded protein binding (GO:0051082)
10 (316)8 (335)8 (318)7 (284)IPR000488: DeathMolecular Function: protein binding (GO:0005515), Biological Process: signal transduction (GO:0007165)
12 (285)11 (266)10 (279)15 (136)IPR004273: Dynein heavy chainMolecular Function: microtubule motor activity (GO:0003777), Biological Process: microtubule-based movement (GO:0007018), Cellular Component: dynein complex (GO:0030286)
29 (96)26 (88)29 (71)26 (58)IPR001660: Sterile alpha motif SAM
198 (7)173 (5)184 (4)184 (3)IPR001680: WD-40 repeat
20 (170)18 (147)17 (152)19 (100)IPR006652: Kelch repeat
144 (14)126 (11)128 (6)114 (7)IPR000504: RNA-binding region RNP-1 (RNA recognition motif)Molecular Function: nucleic acid binding (GO:0003676)
11 (303)10 (287)10 (276)11 (190)IPR003577: Ras small GTPase, Ras typeMolecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264)
11 (311)10 (295)13 (223)13 (163)IPR006689: ARF/SAR superfamilyMolecular Function: GTP binding (GO:0005525)
11 (291)10 (273)8 (314)5 (395)IPR000024: Frizzled CRD region
11 (305)10 (290)11 (252)11 (192)IPR003659: Plexin/semaphorin/integrinBiological Process: development (GO:0007275)
11 (304)10 (289)10 (277)10 (214)IPR003607: Metal-dependent phosphohydrolase, HD regionMolecular Function: catalytic activity (GO:0003824)
17 (202)14 (213) () ()IPR007089: Leucine-rich repeat, cysteine-containing
19 (179)17 (160)20 (127)20 (89)IPR004827: Basic-leucine zipper (bZIP) transcription factorMolecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
35 (78)31 (71)32 (62)31 (47)IPR000980: SH2 motifBiological Process: intracellular signaling cascade (GO:0007242)
11 (293)9 (300)10 (265)9 (220)IPR000555: Mov34/MPN/PAD-1
11 (300)9 (312)12 (234)12 (175)IPR002225: 3-beta hydroxysteroid dehydrogenase/isomeraseMolecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity (GO:0003854), Biological Process: steroid biosynthesis (GO:0006694)
24 (126)20 (126)26 (84)26 (59)IPR001752: Kinesin, motor regionMolecular Function: microtubule motor activity (GO:0003777), Molecular Function: ATP binding (GO:0005524), Cellular Component: microtubule associated complex (GO:0005875), Biological Process: microtubule-based movement (GO:0007018)
24 (119)20 (119)21 (112)14 (141)IPR000175: Sodium:neurotransmitter symporterMolecular Function: neurotransmitter:sodium symporter activity (GO:0005328), Cellular Component: integral to plasma membrane (GO:0005887), Biological Process: neurotransmitter transport (GO:0006836), Cellular Component: membrane (GO:0016020)
24 (121)20 (121)21 (115)22 (74)IPR000299: Band 4.1Cellular Component: cytoskeleton (GO:0005856)
10 (319)9 (307)4 (612)4 (512)IPR001300: Peptidase C2, calpainMolecular Function: calpain activity (GO:0004198), Cellular Component: intracellular (GO:0005622), Biological Process: proteolysis and peptidolysis (GO:0006508)
10 (317)9 (305)7 (363)9 (223)IPR001164: Arf GTPase activating proteinBiological Process: regulation of GTPase activity (GO:0043087)
10 (318)9 (306)8 (322)7 (295)IPR001179: Peptidylprolyl isomerase, FKBP-typeBiological Process: protein folding (GO:0006457)
10 (329)9 (316)18 (140)6 (363)IPR002933: Peptidase M20Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237)
10 (335)9 (322)8 (340)7 (316)IPR004837: Sodium/calcium exchanger membrane regionCellular Component: integral to membrane (GO:0016021)
10 (338)9 (324) () ()IPR006087: SUR2-type hydroxylase/desaturase, catalytic regionMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
10 (342)9 (326)11 (257)7 (323)IPR006569: Regulation of nuclear pre-mRNA protein
10 (334)9 (320)14 (206)16 (124)IPR004148: BARMolecular Function: protein binding (GO:0005515), Cellular Component: cytoplasm (GO:0005737)
10 (333)9 (319)9 (305)8 (265)IPR003689: Zinc/iron permeaseCellular Component: membrane (GO:0016020), Biological Process: metal ion transport (GO:0030001), Molecular Function: metal ion transporter activity (GO:0046873)
10 (328)9 (315)10 (273)7 (305)IPR002909: Cell surface receptor IPT/TIG
10 (344)9 (328)15 (195)5 (467)IPR007484: Peptidase M28Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: peptidase activity (GO:0008233)
18 (182)15 (183)17 (146)14 (142)IPR000412: ABC-2Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626)
18 (184)15 (186)18 (136)18 (107)IPR001487: Bromodomain
38 (74)32 (68)40 (49)27 (55)IPR001623: Heat shock protein DnaJ, N-terminalBiological Process: protein folding (GO:0006457), Molecular Function: heat shock protein binding (GO:0031072), Molecular Function: unfolded protein binding (GO:0051082)
18 (183)16 (171)10 (267)7 (289)IPR000863: SulfotransferaseMolecular Function: sulfotransferase activity (GO:0008146)
18 (191)16 (178)28 (77)13 (161)IPR004272: Odorant binding proteinMolecular Function: molecular function unknown (GO:0005554)
18 (186)16 (175)15 (186)19 (97)IPR001683: Phox-likeBiological Process: intracellular signaling cascade (GO:0007242)
107 (23)91 (21)103 (11)100 (9)IPR002290: Serine/threonine protein kinaseMolecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
32 (86)27 (85) () ()IPR006663: Thioredoxin domain 2Molecular Function: electron transporter activity (GO:0005489), Biological Process: electron transport (GO:0006118)
32 (84)27 (81)30 (67)30 (49)IPR001245: Tyrosine protein kinaseMolecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
12 (286)10 (292)10 (280)10 (215)IPR004839: Aminotransferase, class I and IIBiological Process: biosynthesis (GO:0009058), Molecular Function: transferase activity, transferring nitrogenous groups (GO:0016769)
12 (277)10 (276)9 (296)8 (251)IPR000994: Peptidase M24Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metalloexopeptidase activity (GO:0008235)
12 (282)10 (285)10 (274)10 (213)IPR003029: RNA binding S1Molecular Function: RNA binding (GO:0003723)
136 (15)116 (12)76 (24)72 (21)IPR003591: Leucine-rich repeat, typical subtype
39 (72)33 (67)34 (59)31 (48)IPR001781: LIM, zinc-bindingMolecular Function: zinc ion binding (GO:0008270)
9 (376)8 (371)6 (477)3 (812)IPR008334: 5'-Nucleotidase, C-terminalBiological Process: nucleotide catabolism (GO:0009166), Molecular Function: hydrolase activity (GO:0016787)
9 (371)8 (365)10 (284)10 (219)IPR006688: ADP-ribosylation factorMolecular Function: GTP binding (GO:0005525)
9 (359)8 (353)9 (301)9 (233)IPR002314: tRNA synthetase, class II (G, H, P and S)Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418)
9 (363)8 (357)4 (654)9 (234)IPR003616: SET-related region
9 (362)8 (355)8 (333)6 (364)IPR002937: Amine oxidaseBiological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491)
9 (351)8 (341)7 (364)8 (254)IPR001208: MCMMolecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524), Biological Process: DNA replication initiation (GO:0006270), Molecular Function: DNA-dependent ATPase activity (GO:0008094)
9 (370)8 (363)4 (689)4 (584)IPR006603: Cystinosin/ERS1p repeat
9 (347)8 (334)8 (317)8 (247)IPR000418: EtsMolecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
9 (361)8 (354)11 (251)5 (432)IPR002502: N-acetylmuramoyl-L-alanine amidase, family 2Molecular Function: N-acetylmuramoyl-L-alanine amidase activity (GO:0008745), Biological Process: peptidoglycan catabolism (GO:0009253)
9 (373)8 (368)7 (397)8 (276)IPR007863: Peptidase M16, C-terminal
26 (111)22 (103)25 (89)23 (71)IPR000961: Protein kinase, C-terminalMolecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468)
6 (476)5 (498)2 (936)1 (1257)IPR000183: Orn/DAP/Arg decarboxylase 2Molecular Function: catalytic activity (GO:0003824)
6 (478)5 (502)5 (488)4 (485)IPR000286: Histone deacetylase superfamily
6 (495)5 (528)4 (618)5 (420)IPR001392: Clathrin adaptor complex, medium chainBiological Process: intracellular protein transport (GO:0006886), Cellular Component: clathrin vesicle coat (GO:0030125)
6 (489)5 (523)6 (420)6 (341)IPR001017: Dehydrogenase, E1 componentBiological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624)
6 (486)5 (522)4 (598)6 (339)IPR000909: Phosphatidylinositol-specific phospholipase C, X regionMolecular Function: phospholipase C activity (GO:0004629), Biological Process: signal transduction (GO:0007165), Biological Process: intracellular signaling cascade (GO:0007242)
6 (496)5 (530)3 (764)4 (516)IPR001404: Heat shock protein Hsp90Biological Process: protein folding (GO:0006457), Molecular Function: unfolded protein binding (GO:0051082)
6 (494)5 (527)8 (326)4 (513)IPR001365: Adenosine/AMP deaminaseBiological Process: purine ribonucleoside monophosphate biosynthesis (GO:0009168), Molecular Function: deaminase activity (GO:0019239)
6 (477)5 (499)5 (486)6 (330)IPR000209: Peptidase S8 and S53, subtilisin, kexin, sedolisinMolecular Function: subtilase activity (GO:0004289), Biological Process: proteolysis and peptidolysis (GO:0006508)
24 (120)21 (107)20 (122)23 (68)IPR000198: RhoGAP
68 (38)58 (38)56 (38)39 (40)IPR003439: ABC transporter relatedMolecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887)
16 (204)14 (197)11 (244)14 (140)IPR000159: RABiological Process: signal transduction (GO:0007165)
16 (212)14 (206)13 (217)11 (189)IPR003347: Transcription factor jumonji, jmjC
16 (213)14 (212)16 (174)6 (388)IPR006629: LPS-induced tumor necrosis factor alpha factor
13 (269)11 (268)9 (307)8 (273)IPR006553: Leucine-rich repeat, cysteine-containing subtype
13 (262)11 (261)10 (272)10 (210)IPR002129: Pyridoxal-dependent decarboxylaseBiological Process: amino acid metabolism (GO:0006520), Molecular Function: carboxy-lyase activity (GO:0016831)
13 (274)11 (272)14 (209)14 (152)IPR011616: bZIP transcription factor, bZIP_1Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355)
13 (251)11 (255)8 (316)10 (199)IPR000342: Regulator of G protein signallingMolecular Function: signal transducer activity (GO:0004871)
112 (22)97 (18) () ()IPR007114: Major facilitator superfamilyMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021)
90 (26)77 (28)84 (19)69 (23)IPR002048: Calcium-binding EF-handMolecular Function: calcium ion binding (GO:0005509)
20 (166)17 (161)26 (87)18 (108)IPR005834: Haloacid dehalogenase-like hydrolaseMolecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152)
20 (160)17 (153)15 (179)16 (117)IPR000253: Forkhead-associated
41 (64)35 (66)46 (43)32 (45)IPR001993: Mitochondrial substrate carrierMolecular Function: binding (GO:0005488), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
8 (408)7 (413)7 (393)8 (269)IPR006055: ExonucleaseMolecular Function: exonuclease activity (GO:0004527), Cellular Component: intracellular (GO:0005622)
8 (391)7 (382)7 (361)6 (342)IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunitMolecular Function: signal transducer activity (GO:0004871), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Molecular Function: guanyl nucleotide binding (GO:0019001)
8 (403)7 (405)10 (278)6 (374)IPR003890: Initiation factor eIF-4 gamma, middleMolecular Function: RNA binding (GO:0003723)
8 (413)7 (423)8 (349)11 (195)IPR008250: E1-E2 ATPase-associated regionMolecular Function: ATP binding (GO:0005524), Cellular Component: membrane (GO:0016020), Molecular Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)
8 (412)7 (422)6 (476)5 (468)IPR008211: Laminin, N-terminalCellular Component: extracellular matrix (sensu Metazoa) (GO:0005578)
8 (399)7 (393)5 (519)5 (426)IPR002083: MATH
8 (392)7 (387)8 (323)8 (253)IPR001206: Diacylglycerol kinase, catalytic regionMolecular Function: diacylglycerol kinase activity (GO:0004143), Biological Process: protein kinase C activation (GO:0007205)
8 (390)7 (379) () ()IPR000862: Replication factor C conserved regionMolecular Function: DNA binding (GO:0003677), Biological Process: DNA replication (GO:0006260), Cellular Component: protein complex (GO:0043234)
8 (414)7 (427) () ()IPR011761: ATP-grasp foldMolecular Function: catalytic activity (GO:0003824)
28 (99)24 (92)20 (123)25 (62)IPR000219: DH
21 (150)18 (142)22 (105)15 (130)IPR001320: Ionotropic glutamate receptorMolecular Function: ionotropic glutamate receptor activity (GO:0004970), Molecular Function: glutamate-gated ion channel activity (GO:0005234), Cellular Component: membrane (GO:0016020)
21 (153)18 (143)16 (169)12 (176)IPR002422: Amino acid/polyamine transporter IIMolecular Function: amino acid-polyamine transporter activity (GO:0005279), Biological Process: amino acid transport (GO:0006865), Cellular Component: membrane (GO:0016020)
21 (158)18 (149)22 (111)22 (78)IPR011510: Sterile alpha motif homology 2
14 (246)12 (241)12 (239)12 (177)IPR003877: SPla/RYanodine receptor SPRY
14 (242)12 (229)15 (181)11 (184)IPR001007: von Willebrand factor, type C
22 (146)19 (137)16 (176)9 (244)IPR011583: Chitinase IIMolecular Function: chitinase activity (GO:0004568), Biological Process: chitin catabolism (GO:0006032)
181 (10)156 (7)107 (10)107 (8)IPR001611: Leucine-rich repeat
7 (458)6 (491)24 (99)6 (386)IPR006620: Prolyl 4-hydroxylase, alpha subunitMolecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706), Biological Process: protein metabolism (GO:0019538)
7 (443)6 (468)6 (448)6 (362)IPR002877: Ribosomal RNA methyltransferase RrmJ/FtsJ
7 (446)6 (471)6 (450)6 (367)IPR003104: Actin-binding FH2Molecular Function: actin binding (GO:0003779), Biological Process: cell organization and biogenesis (GO:0016043)
7 (455)6 (489)7 (394)5 (462)IPR006596: Nucleotide binding protein, PINc
7 (434)6 (450)8 (325)6 (346)IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductaseBiological Process: electron transport (GO:0006118), Molecular Function: disulfide oxidoreductase activity (GO:0015036)
7 (449)6 (479)8 (339)7 (312)IPR004156: Organic anion transporter polypeptide OATPMolecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020)
7 (444)6 (469) () ()IPR003009: FMN/related compound-binding core
7 (436)6 (455)7 (370)8 (257)IPR001529: DNA-directed RNA polymerase, M/15 kDa subunitMolecular Function: DNA binding (GO:0003677), Molecular Function: DNA-directed RNA polymerase activity (GO:0003899), Biological Process: transcription (GO:0006350)
7 (419)6 (435)5 (490)5 (403)IPR000409: Beige/BEACH
7 (422)6 (440)6 (416)7 (285)IPR000640: Elongation factor G, C-terminalMolecular Function: GTP binding (GO:0005525)
7 (448)6 (478)8 (338)9 (235)IPR004012: RUN
7 (428)6 (447)5 (504)7 (293)IPR001060: Cdc15/Fes/CIP4
7 (427)6 (446)9 (297)6 (340)IPR001012: UBX
43 (61)37 (64)38 (52)33 (44)IPR005821: Ion transport proteinMolecular Function: ion channel activity (GO:0005216), Biological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020)