Apis mellifera (honey bee)
10157 total genes
( 71% w domains) | Drosophila melanogaster (fruit fly)
13450 total genes
( 68% w domains) | Homo sapiens (man)
22218 total genes
( 72% w domains) | Family | GO terms |
| 2275 | 3171 | 5083 | Transmembrane | |
| 1081 | 2895 | 4083 | Signal peptide | |
| 247 (1) | 314 (1) | 778 (1) | IPR007087: Zinc finger, C2H2-type | Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270) |
| 201 (2) | 207 (3) | 464 (3) | IPR000719: Protein kinase | Molecular Function: protein kinase activity (GO:0004672), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468) |
| 184 (3) | 184 (4) | 261 (9) | IPR001680: WD-40 repeat | |
| 120 (4) | 121 (8) | 462 (4) | IPR003599: Immunoglobulin subtype | |
| 117 (5) | 119 (9) | 285 (7) | IPR001841: Zinc finger, RING-type | Cellular Component: ubiquitin ligase complex (GO:0000151), Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Molecular Function: zinc ion binding (GO:0008270), Biological Process: protein ubiquitination (GO:0016567) |
| 116 (6) | 122 (7) | 133 (28) | IPR003593: AAA ATPase | Molecular Function: nucleotide binding (GO:0000166), Molecular Function: nucleoside-triphosphatase activity (GO:0017111) |
| 114 (7) | 128 (6) | 236 (12) | IPR000504: RNA-binding region RNP-1 (RNA recognition motif) | Molecular Function: nucleic acid binding (GO:0003676) |
| 107 (8) | 107 (10) | 221 (15) | IPR001611: Leucine-rich repeat | |
| 100 (9) | 103 (11) | 244 (11) | IPR002290: Serine/threonine protein kinase | Molecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468) |
| 98 (10) | 130 (5) | 99 (38) | IPR011701: Major facilitator superfamily MFS_1 | |
| 97 (11) | 82 (20) | 247 (10) | IPR002110: Ankyrin | |
| 97 (12) | 102 (12) | 369 (5) | IPR007110: Immunoglobulin-like | |
| 96 (13) | 100 (14) | 220 (16) | IPR003598: Immunoglobulin C2 type | |
| 89 (14) | 99 (15) | 226 (14) | IPR001356: Homeobox | Molecular Function: DNA binding (GO:0003677), Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 83 (15) | 61 (33) | () | IPR004117: Olfactory receptor, Drosophila | Molecular Function: olfactory receptor activity (GO:0004984), Molecular Function: odorant binding (GO:0005549), Biological Process: perception of smell (GO:0007608), Cellular Component: membrane (GO:0016020) |
| 78 (16) | 67 (30) | 265 (8) | IPR001849: Pleckstrin-like | |
| 78 (17) | 74 (25) | 109 (34) | IPR011545: DEAD/DEAH box helicase, N-terminal | Molecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524) |
| 75 (18) | 76 (22) | 140 (26) | IPR001440: TPR repeat | |
| 74 (19) | 76 (23) | 107 (35) | IPR001650: Helicase, C-terminal | Molecular Function: nucleic acid binding (GO:0003676), Molecular Function: helicase activity (GO:0004386), Molecular Function: ATP binding (GO:0005524) |
| 73 (20) | 71 (28) | 208 (17) | IPR001452: SH3 | |
| 72 (21) | 76 (24) | 160 (23) | IPR003591: Leucine-rich repeat, typical subtype | |
| 71 (22) | 68 (29) | 166 (22) | IPR000210: BTB/POZ | Molecular Function: protein binding (GO:0005515) |
| 69 (23) | 84 (19) | 183 (19) | IPR002048: Calcium-binding EF-hand | Molecular Function: calcium ion binding (GO:0005509) |
| 69 (24) | 89 (16) | 232 (13) | IPR003656: Zinc finger, BED-type predicted | Molecular Function: DNA binding (GO:0003677) |
| 67 (25) | 56 (36) | 102 (37) | IPR000357: HEAT | |
| 66 (26) | 63 (31) | 143 (25) | IPR001478: PDZ/DHR/GLGF | Molecular Function: protein binding (GO:0005515) |
| 63 (27) | 56 (39) | 180 (20) | IPR011511: Variant SH3 | |
| 58 (28) | 243 (2) | 120 (30) | IPR001254: Peptidase S1 and S6, chymotrypsin/Hap | Molecular Function: trypsin activity (GO:0004295), Biological Process: proteolysis and peptidolysis (GO:0006508) |
| 58 (29) | 61 (32) | 179 (21) | IPR003961: Fibronectin, type III | |
| 57 (30) | 61 (34) | 191 (18) | IPR006210: Type I EGF | |
| 55 (31) | 71 (27) | 704 (2) | IPR000276: Rhodopsin-like GPCR superfamily | Molecular Function: rhodopsin-like receptor activity (GO:0001584), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Cellular Component: integral to membrane (GO:0016021) |
| 53 (32) | 58 (35) | 112 (31) | IPR001092: Basic helix-loop-helix dimerisation region bHLH | Cellular Component: nucleus (GO:0005634), Molecular Function: transcription regulator activity (GO:0030528), Biological Process: regulation of transcription (GO:0045449) |
| 53 (33) | 72 (26) | 38 (116) | IPR005828: General substrate transporter | Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021) |
| 51 (34) | 55 (40) | 130 (29) | IPR001806: Ras GTPase | Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264) |
| 48 (35) | 40 (47) | 134 (27) | IPR000008: C2 | |
| 47 (36) | 86 (18) | 61 (64) | IPR001128: Cytochrome P450 | Molecular Function: monooxygenase activity (GO:0004497), Molecular Function: iron ion binding (GO:0005506), Biological Process: electron transport (GO:0006118), Molecular Function: heme binding (GO:0020037) |
| 44 (37) | 40 (50) | 150 (24) | IPR006209: EGF-like | |
| 43 (38) | 56 (37) | 57 (68) | IPR002198: Short-chain dehydrogenase/reductase SDR | Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491) |
| 40 (39) | 42 (45) | 81 (48) | IPR001965: Zinc finger, PHD-type | Molecular Function: protein binding (GO:0005515), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Molecular Function: zinc ion binding (GO:0008270) |
| 39 (40) | 56 (38) | 49 (83) | IPR003439: ABC transporter related | Molecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887) |
| 39 (41) | 41 (46) | 44 (102) | IPR003959: AAA ATPase, central region | Molecular Function: ATP binding (GO:0005524) |
| 38 (42) | 81 (21) | 2 (1621) | IPR002557: Chitin binding Peritrophin-A | Cellular Component: extracellular region (GO:0005576), Biological Process: chitin metabolism (GO:0006030), Molecular Function: chitin binding (GO:0008061) |
| 33 (43) | 43 (44) | 44 (101) | IPR002172: Low density lipoprotein-receptor, class A | |
| 33 (44) | 38 (52) | 111 (32) | IPR005821: Ion transport protein | Molecular Function: ion channel activity (GO:0005216), Biological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020) |
| 32 (45) | 46 (43) | 54 (71) | IPR001993: Mitochondrial substrate carrier | Molecular Function: binding (GO:0005488), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 31 (46) | 100 (13) | () | IPR000618: Insect cuticle protein | Molecular Function: structural constituent of cuticle (GO:0042302) |
| 31 (47) | 32 (62) | 109 (33) | IPR000980: SH2 motif | Biological Process: intracellular signaling cascade (GO:0007242) |
| 31 (48) | 34 (59) | 69 (54) | IPR001781: LIM, zinc-binding | Molecular Function: zinc ion binding (GO:0008270) |
| 30 (49) | 30 (67) | 92 (39) | IPR001245: Tyrosine protein kinase | Molecular Function: protein-tyrosine kinase activity (GO:0004713), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468) |
| 29 (50) | 32 (63) | 103 (36) | IPR001881: EGF-like calcium-binding | Molecular Function: calcium ion binding (GO:0005509) |
| 28 (51) | 31 (66) | 86 (42) | IPR000048: IQ calmodulin-binding region | |
| 28 (52) | 27 (78) | 44 (98) | IPR001214: Nuclear protein SET | |
| 28 (53) | 36 (53) | 60 (66) | IPR001810: Cyclin-like F-box | |
| 27 (54) | 32 (60) | 46 (90) | IPR000608: Ubiquitin-conjugating enzyme, E2 | Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512), Molecular Function: ubiquitin-like activating enzyme activity (GO:0008642) |
| 27 (55) | 40 (49) | 49 (81) | IPR001623: Heat shock protein DnaJ, N-terminal | Biological Process: protein folding (GO:0006457), Molecular Function: heat shock protein binding (GO:0031072), Molecular Function: unfolded protein binding (GO:0051082) |
| 27 (56) | 35 (56) | 15 (317) | IPR002018: Carboxylesterase, type B | |
| 26 (57) | 24 (93) | 50 (77) | IPR000571: Zinc finger, CCCH-type | Molecular Function: nucleic acid binding (GO:0003676) |
| 26 (58) | 29 (71) | 78 (51) | IPR001660: Sterile alpha motif SAM | |
| 26 (59) | 26 (84) | 45 (93) | IPR001752: Kinesin, motor region | Molecular Function: microtubule motor activity (GO:0003777), Molecular Function: ATP binding (GO:0005524), Cellular Component: microtubule associated complex (GO:0005875), Biological Process: microtubule-based movement (GO:0007018) |
| 26 (60) | 26 (85) | 62 (62) | IPR002219: Protein kinase C, phorbol ester/diacylglycerol binding | Biological Process: intracellular signaling cascade (GO:0007242) |
| 26 (61) | 89 (17) | 1 (3049) | IPR012934: Zinc finger, AD-type | |
| 25 (62) | 20 (123) | 57 (67) | IPR000219: DH | |
| 25 (63) | 25 (88) | 83 (46) | IPR000483: Cysteine-rich flanking region, C-terminal | |
| 25 (64) | 27 (79) | 65 (59) | IPR001715: Calponin-like actin-binding | |
| 24 (65) | 24 (97) | 48 (87) | IPR001005: Myb, DNA-binding | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634) |
| 24 (66) | 24 (98) | 44 (100) | IPR001878: Zinc finger, CCHC-type | Molecular Function: nucleic acid binding (GO:0003676) |
| 24 (67) | 13 (218) | () | IPR003534: Major royal jelly protein | |
| 23 (68) | 20 (122) | 68 (55) | IPR000198: RhoGAP | |
| 23 (69) | 24 (94) | 53 (73) | IPR000626: Ubiquitin | Biological Process: protein modification (GO:0006464) |
| 23 (70) | 22 (103) | 62 (61) | IPR000910: HMG1/2 (high mobility group) box | Molecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 23 (71) | 25 (89) | 53 (74) | IPR000961: Protein kinase, C-terminal | Molecular Function: protein serine/threonine kinase activity (GO:0004674), Molecular Function: ATP binding (GO:0005524), Biological Process: protein amino acid phosphorylation (GO:0006468) |
| 23 (72) | 18 (138) | 45 (94) | IPR001791: Laminin G | |
| 23 (73) | 29 (72) | 36 (126) | IPR004087: KH | Molecular Function: nucleic acid binding (GO:0003676) |
| 22 (74) | 21 (115) | 48 (85) | IPR000299: Band 4.1 | Cellular Component: cytoskeleton (GO:0005856) |
| 22 (75) | 23 (100) | 44 (97) | IPR001202: WW/Rsp5/WWP | |
| 22 (76) | 22 (106) | 54 (70) | IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 | Molecular Function: cysteine-type endopeptidase activity (GO:0004197), Molecular Function: ubiquitin thiolesterase activity (GO:0004221), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511) |
| 22 (77) | 30 (69) | 61 (65) | IPR003579: Ras small GTPase, Rab type | Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264), Biological Process: protein transport (GO:0015031) |
| 22 (78) | 22 (111) | 72 (53) | IPR011510: Sterile alpha motif homology 2 | |
| 21 (79) | 21 (114) | 47 (88) | IPR000195: RabGAP/TBC | |
| 21 (80) | 17 (144) | 48 (84) | IPR000225: Armadillo | |
| 21 (81) | 16 (163) | 65 (58) | IPR000884: Thrombospondin, type I | |
| 21 (82) | 21 (118) | 47 (89) | IPR001628: Nuclear hormone receptor, DNA-binding | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 21 (83) | 26 (86) | 49 (82) | IPR002867: Zinc finger, C6HC-type | |
| 21 (84) | 28 (76) | 35 (129) | IPR004088: KH, type 1 | Molecular Function: nucleic acid binding (GO:0003676) |
| 21 (85) | 21 (120) | 44 (103) | IPR006029: Neurotransmitter-gated ion-channel transmembrane region | Biological Process: ion transport (GO:0006811), Cellular Component: membrane (GO:0016020), Molecular Function: neurotransmitter receptor activity (GO:0030594) |
| 21 (86) | 21 (121) | 46 (91) | IPR006202: Neurotransmitter-gated ion-channel ligand-binding | Molecular Function: extracellular ligand-gated ion channel activity (GO:0005230), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 20 (87) | 15 (178) | 1 (2023) | IPR000172: Glucose-methanol-choline oxidoreductase | Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491) |
| 20 (88) | 30 (68) | 22 (210) | IPR001251: Cellular retinaldehyde-binding/triple function, C-terminal | |
| 20 (89) | 20 (127) | 50 (78) | IPR004827: Basic-leucine zipper (bZIP) transcription factor | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 20 (90) | 12 (241) | 89 (40) | IPR007125: Histone core | Molecular Function: DNA binding (GO:0003677) |
| 20 (91) | 15 (196) | 1 (2664) | IPR007867: GMC oxidoreductase | Molecular Function: oxidoreductase activity, acting on CH-OH group of donors (GO:0016614), Molecular Function: FAD binding (GO:0050660) |
| 20 (92) | 17 (156) | 37 (122) | IPR012680: Laminin G, subdomain 2 | |
| 19 (93) | 26 (81) | 34 (131) | IPR000449: Ubiquitin-associated | |
| 19 (94) | 18 (133) | 34 (133) | IPR000595: Cyclic nucleotide-binding | |
| 19 (95) | 28 (75) | 17 (284) | IPR001509: NAD-dependent epimerase/dehydratase | Molecular Function: catalytic activity (GO:0003824), Biological Process: nucleotide-sugar metabolism (GO:0009225), Molecular Function: NAD binding (GO:0051287) |
| 19 (96) | 12 (229) | 38 (115) | IPR001609: Myosin head, motor region | Molecular Function: motor activity (GO:0003774), Molecular Function: ATP binding (GO:0005524), Cellular Component: myosin (GO:0016459) |
| 19 (97) | 15 (186) | 44 (99) | IPR001683: Phox-like | Biological Process: intracellular signaling cascade (GO:0007242) |
| 19 (98) | 23 (101) | 37 (118) | IPR001828: Extracellular ligand-binding receptor | |
| 19 (99) | 32 (65) | 27 (171) | IPR004843: Metallophosphoesterase | Molecular Function: hydrolase activity (GO:0016787) |
| 19 (100) | 17 (152) | 68 (56) | IPR006652: Kelch repeat | |
| 19 (101) | 17 (153) | 40 (112) | IPR006670: Cyclin | |
| 18 (102) | 34 (58) | 32 (141) | IPR000301: CD9/CD37/CD63 antigen | Cellular Component: integral to membrane (GO:0016021) |
| 18 (103) | 16 (161) | 49 (80) | IPR000536: Nuclear hormone receptor, ligand-binding | Molecular Function: transcription factor activity (GO:0003700), Molecular Function: steroid hormone receptor activity (GO:0003707), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 18 (104) | 24 (96) | 48 (86) | IPR000859: CUB | |
| 18 (105) | 25 (90) | 20 (236) | IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase | Biological Process: intracellular signaling cascade (GO:0007242), Biological Process: cyclic nucleotide biosynthesis (GO:0009190), Molecular Function: phosphorus-oxygen lyase activity (GO:0016849) |
| 18 (106) | 18 (135) | 21 (226) | IPR001163: Like-Sm ribonucleoprotein, core | Cellular Component: nucleus (GO:0005634), Cellular Component: small nucleolar ribonucleoprotein complex (GO:0005732), Biological Process: mRNA processing (GO:0006397) |
| 18 (107) | 18 (136) | 40 (109) | IPR001487: Bromodomain | |
| 18 (108) | 26 (87) | 38 (117) | IPR005834: Haloacid dehalogenase-like hydrolase | Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152) |
| 18 (109) | 16 (175) | 68 (57) | IPR011498: Kelch | |
| 18 (110) | 18 (143) | 40 (114) | IPR011700: Basic leucine zipper | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 17 (111) | 21 (113) | 19 (247) | IPR000182: GCN5-related N-acetyltransferase | Molecular Function: N-acetyltransferase activity (GO:0008080) |
| 17 (112) | 17 (148) | 80 (50) | IPR002126: Cadherin | Molecular Function: calcium ion binding (GO:0005509), Biological Process: homophilic cell adhesion (GO:0007156), Cellular Component: membrane (GO:0016020) |
| 17 (113) | 16 (170) | 20 (241) | IPR002893: Zinc finger, MYND-type | |
| 17 (114) | 17 (149) | 21 (228) | IPR002917: GTP-binding protein, HSR1-related | |
| 17 (115) | 19 (131) | 22 (218) | IPR006662: Thioredoxin-related | Molecular Function: electron transporter activity (GO:0005489), Biological Process: electron transport (GO:0006118) |
| 17 (116) | 16 (177) | 31 (151) | IPR012679: Laminin G, subdomain 1 | |
| 16 (117) | 15 (179) | 25 (177) | IPR000253: Forkhead-associated | |
| 16 (118) | 12 (225) | 27 (169) | IPR000306: Zinc finger, FYVE-type | Molecular Function: zinc ion binding (GO:0008270) |
| 16 (119) | 17 (145) | 31 (146) | IPR000330: SNF2-related | Molecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524) |
| 16 (120) | 15 (180) | 86 (43) | IPR000372: Cysteine-rich flanking region, N-terminal | |
| 16 (121) | 16 (160) | 20 (233) | IPR000467: D111/G-patch | Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622) |
| 16 (122) | 14 (201) | 16 (295) | IPR000717: Proteasome component region PCI | |
| 16 (123) | 18 (134) | 29 (162) | IPR000795: Protein synthesis factor, GTP-binding | Molecular Function: GTP binding (GO:0005525), Biological Process: protein biosynthesis (GO:0006412) |
| 16 (124) | 14 (206) | 33 (140) | IPR004148: BAR | Molecular Function: protein binding (GO:0005515), Cellular Component: cytoplasm (GO:0005737) |
| 16 (125) | 18 (141) | 27 (172) | IPR006594: Lissencephaly type-1-like homology motif | |
| 15 (126) | 40 (48) | 24 (183) | IPR000073: Alpha/beta hydrolase fold | |
| 15 (127) | 16 (158) | 41 (106) | IPR000242: Tyrosine specific protein phosphatase | Molecular Function: protein tyrosine phosphatase activity (GO:0004725), Biological Process: protein amino acid dephosphorylation (GO:0006470) |
| 15 (128) | 9 (293) | 9 (504) | IPR000560: Histidine acid phosphatase | Molecular Function: acid phosphatase activity (GO:0003993) |
| 15 (129) | 28 (74) | 27 (170) | IPR000873: AMP-dependent synthetase and ligase | Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152) |
| 15 (130) | 22 (105) | 18 (263) | IPR001320: Ionotropic glutamate receptor | Molecular Function: ionotropic glutamate receptor activity (GO:0004970), Molecular Function: glutamate-gated ion channel activity (GO:0005234), Cellular Component: membrane (GO:0016020) |
| 15 (131) | 18 (137) | 42 (104) | IPR001766: Fork head transcription factor | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 15 (132) | 9 (300) | 26 (173) | IPR002017: Spectrin repeat | |
| 15 (133) | 16 (168) | 37 (119) | IPR002130: Peptidyl-prolyl cis-trans isomerase, cyclophilin type | Biological Process: protein folding (GO:0006457) |
| 15 (134) | 12 (235) | 35 (128) | IPR003008: Tubulin/FtsZ, GTPase | |
| 15 (135) | 15 (189) | 34 (134) | IPR004000: Actin/actin-like | Molecular Function: protein binding (GO:0005515) |
| 15 (136) | 10 (279) | 13 (377) | IPR004273: Dynein heavy chain | Molecular Function: microtubule motor activity (GO:0003777), Biological Process: microtubule-based movement (GO:0007018), Cellular Component: dynein complex (GO:0030286) |
| 15 (137) | 15 (192) | 22 (217) | IPR004841: Amino acid permease-associated region | Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 15 (138) | 13 (222) | 30 (159) | IPR006671: Cyclin, N-terminal | Biological Process: regulation of progression through cell cycle (GO:0000074) |
| 15 (139) | 10 (289) | 64 (60) | IPR008160: Collagen triple helix repeat | Cellular Component: cytoplasm (GO:0005737), Biological Process: phosphate transport (GO:0006817) |
| 14 (140) | 11 (244) | 36 (123) | IPR000159: RA | Biological Process: signal transduction (GO:0007165) |
| 14 (141) | 21 (112) | 21 (221) | IPR000175: Sodium:neurotransmitter symporter | Molecular Function: neurotransmitter:sodium symporter activity (GO:0005328), Cellular Component: integral to plasma membrane (GO:0005887), Biological Process: neurotransmitter transport (GO:0006836), Cellular Component: membrane (GO:0016020) |
| 14 (142) | 17 (146) | 5 (811) | IPR000412: ABC-2 | Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626) |
| 14 (143) | 14 (200) | 28 (167) | IPR000569: HECT | Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Cellular Component: intracellular (GO:0005622), Biological Process: protein modification (GO:0006464), Biological Process: ubiquitin cycle (GO:0006512) |
| 14 (144) | 32 (61) | 9 (505) | IPR000734: Lipase | Molecular Function: catalytic activity (GO:0003824), Biological Process: lipid metabolism (GO:0006629) |
| 14 (145) | 12 (232) | 81 (49) | IPR002035: von Willebrand factor, type A | |
| 14 (146) | 20 (125) | 7 (646) | IPR002076: GNS1/SUR4 membrane protein | Cellular Component: integral to membrane (GO:0016021) |
| 14 (147) | 22 (108) | 40 (111) | IPR002350: Proteinase inhibitor I1, Kazal | |
| 14 (148) | 16 (171) | 25 (182) | IPR004161: Elongation factor Tu, domain 2 | Molecular Function: GTP binding (GO:0005525) |
| 14 (149) | 10 (285) | 15 (327) | IPR006935: Type III restriction enzyme, res subunit | Molecular Function: ATP binding (GO:0005524) |
| 14 (150) | 14 (208) | 18 (273) | IPR007502: Helicase-associated region | Molecular Function: helicase activity (GO:0004386) |
| 14 (151) | 12 (242) | 36 (127) | IPR008280: Tubulin/FtsZ, C-terminal | Molecular Function: GTPase activity (GO:0003924), Molecular Function: GTP binding (GO:0005525), Cellular Component: protein complex (GO:0043234), Biological Process: protein polymerization (GO:0051258) |
| 14 (152) | 14 (209) | 37 (121) | IPR011616: bZIP transcription factor, bZIP_1 | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 13 (153) | 16 (157) | 30 (152) | IPR000014: PAS | Molecular Function: signal transducer activity (GO:0004871), Biological Process: signal transduction (GO:0007165) |
| 13 (154) | 22 (104) | 23 (194) | IPR001140: ABC transporter, transmembrane region | Molecular Function: ATP binding (GO:0005524), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021), Molecular Function: ATPase activity, coupled to transmembrane movement of substances (GO:0042626) |
| 13 (155) | 26 (83) | 19 (253) | IPR001353: 20S proteasome, A and B subunits | Molecular Function: threonine endopeptidase activity (GO:0004298), Cellular Component: proteasome core complex (sensu Eukaryota) (GO:0005839), Biological Process: ubiquitin-dependent protein catabolism (GO:0006511) |
| 13 (156) | 15 (185) | 14 (345) | IPR001507: Endoglin/CD105 antigen | |
| 13 (157) | 12 (230) | 25 (179) | IPR001610: PAC motif | Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Biological Process: signal transduction (GO:0007165) |
| 13 (158) | 11 (249) | 30 (156) | IPR002049: Laminin-type EGF-like | Molecular Function: structural molecule activity (GO:0005198) |
| 13 (159) | 15 (188) | 37 (120) | IPR003595: Protein tyrosine phosphatase, catalytic region | Molecular Function: protein tyrosine phosphatase activity (GO:0004725) |
| 13 (160) | 54 (41) | 2 (1694) | IPR004119: Protein of unknown function DUF227 | Molecular Function: molecular function unknown (GO:0005554) |
| 13 (161) | 28 (77) | () | IPR004272: Odorant binding protein | Molecular Function: molecular function unknown (GO:0005554) |
| 13 (162) | 36 (54) | () | IPR006170: Pheromone/general odorant binding protein, PBP/GOBP | Molecular Function: odorant binding (GO:0005549), Biological Process: transport (GO:0006810) |
| 13 (163) | 13 (223) | 29 (166) | IPR006689: ARF/SAR superfamily | Molecular Function: GTP binding (GO:0005525) |
| 13 (164) | 22 (110) | 40 (113) | IPR011497: Protease inhibitor, Kazal-type | |
| 13 (165) | 19 (132) | 50 (79) | IPR011705: BTB/Kelch-associated | |
| 13 (166) | 20 (130) | () | IPR012464: Protein of unknown function DUF1676 | |
| 12 (167) | 12 (226) | 41 (107) | IPR000340: Dual specificity protein phosphatase | Biological Process: protein amino acid dephosphorylation (GO:0006470), Molecular Function: protein tyrosine/serine/threonine phosphatase activity (GO:0008138) |
| 12 (168) | 11 (245) | 19 (249) | IPR000403: Phosphatidylinositol 3- and 4-kinase, catalytic | Molecular Function: phosphotransferase activity, alcohol group as acceptor (GO:0016773) |
| 12 (169) | 14 (199) | 17 (276) | IPR000433: Zinc finger, ZZ-type | Molecular Function: zinc ion binding (GO:0008270) |
| 12 (170) | 13 (210) | 20 (237) | IPR001159: Double-stranded RNA binding | Molecular Function: double-stranded RNA binding (GO:0003725), Cellular Component: intracellular (GO:0005622) |
| 12 (171) | 16 (165) | 12 (389) | IPR001199: Cytochrome b5 | |
| 12 (172) | 12 (228) | 22 (211) | IPR001357: BRCT | Cellular Component: intracellular (GO:0005622) |
| 12 (173) | 14 (204) | 22 (214) | IPR001876: Zinc finger, RanBP2-type | |
| 12 (174) | 10 (271) | 18 (266) | IPR002123: Phospholipid/glycerol acyltransferase | Biological Process: metabolism (GO:0008152), Molecular Function: acyltransferase activity (GO:0008415) |
| 12 (175) | 12 (234) | 14 (348) | IPR002225: 3-beta hydroxysteroid dehydrogenase/isomerase | Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity (GO:0003854), Biological Process: steroid biosynthesis (GO:0006694) |
| 12 (176) | 16 (169) | 18 (267) | IPR002422: Amino acid/polyamine transporter II | Molecular Function: amino acid-polyamine transporter activity (GO:0005279), Biological Process: amino acid transport (GO:0006865), Cellular Component: membrane (GO:0016020) |
| 12 (177) | 12 (239) | 87 (41) | IPR003877: SPla/RYanodine receptor SPRY | |
| 12 (178) | 9 (313) | 9 (552) | IPR011704: ATPase associated with various cellular activities, AAA_5 | Molecular Function: ATP binding (GO:0005524), Molecular Function: ATPase activity (GO:0016887) |
| 11 (179) | 14 (198) | 23 (191) | IPR000086: NUDIX hydrolase | |
| 11 (180) | 6 (410) | 74 (52) | IPR000315: Zinc finger, B-box | Cellular Component: intracellular (GO:0005622), Molecular Function: zinc ion binding (GO:0008270) |
| 11 (181) | 9 (292) | 17 (275) | IPR000408: Regulator of chromosome condensation, RCC1 | |
| 11 (182) | 16 (159) | 54 (69) | IPR000436: Sushi/SCR/CCP | |
| 11 (183) | 20 (124) | 30 (153) | IPR000953: Chromo | Cellular Component: chromatin (GO:0000785), Molecular Function: chromatin binding (GO:0003682), Cellular Component: nucleus (GO:0005634), Biological Process: chromatin assembly or disassembly (GO:0006333) |
| 11 (184) | 15 (181) | 36 (124) | IPR001007: von Willebrand factor, type C | |
| 11 (185) | 21 (117) | 22 (213) | IPR001594: Zinc finger, DHHC-type | Molecular Function: metal ion binding (GO:0046872) |
| 11 (186) | 15 (187) | 18 (265) | IPR001932: Protein phosphatase 2C-like | Molecular Function: catalytic activity (GO:0003824) |
| 11 (187) | 35 (57) | 14 (347) | IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase | Biological Process: metabolism (GO:0008152), Molecular Function: transferase activity, transferring hexosyl groups (GO:0016758) |
| 11 (188) | 12 (236) | 51 (76) | IPR003131: K+ channel tetramerisation | Molecular Function: voltage-gated potassium channel activity (GO:0005249), Biological Process: potassium ion transport (GO:0006813), Cellular Component: voltage-gated potassium channel complex (GO:0008076), Cellular Component: membrane (GO:0016020) |
| 11 (189) | 13 (217) | 30 (158) | IPR003347: Transcription factor jumonji, jmjC | |
| 11 (190) | 10 (276) | 24 (186) | IPR003577: Ras small GTPase, Ras type | Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264) |
| 11 (191) | 12 (237) | 22 (215) | IPR003604: Zinc finger, U1-type | Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: nucleus (GO:0005634), Molecular Function: zinc ion binding (GO:0008270) |
| 11 (192) | 11 (252) | 45 (96) | IPR003659: Plexin/semaphorin/integrin | Biological Process: development (GO:0007275) |
| 11 (193) | 7 (385) | 10 (480) | IPR003958: Transcription factor CBF/NF-Y/archaeal histone | Molecular Function: DNA binding (GO:0003677) |
| 11 (194) | 11 (255) | 10 (485) | IPR004344: Tubulin-tyrosine ligase | Molecular Function: tubulin-tyrosine ligase activity (GO:0004835), Biological Process: protein modification (GO:0006464) |
| 11 (195) | 8 (349) | 23 (205) | IPR008250: E1-E2 ATPase-associated region | Molecular Function: ATP binding (GO:0005524), Cellular Component: membrane (GO:0016020), Molecular Function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) |
| 11 (196) | 13 (224) | 17 (293) | IPR011709: Protein of unknown function DUF1605 | Molecular Function: ATP binding (GO:0005524), Molecular Function: ATP-dependent helicase activity (GO:0008026) |
| 10 (197) | 8 (315) | 19 (248) | IPR000313: PWWP | |
| 10 (198) | 10 (263) | 25 (178) | IPR000337: GPCR, family 3, metabotropic glutamate receptor-like | Molecular Function: metabotropic glutamate, GABA-B-like receptor activity (GO:0008067), Cellular Component: membrane (GO:0016020) |
| 10 (199) | 8 (316) | 31 (147) | IPR000342: Regulator of G protein signalling | Molecular Function: signal transducer activity (GO:0004871) |
| 10 (200) | 22 (102) | 45 (92) | IPR000832: GPCR, family 2, secretin-like | Molecular Function: G-protein coupled receptor activity (GO:0004930), Cellular Component: membrane (GO:0016020) |
| 10 (201) | 24 (95) | 22 (208) | IPR000834: Peptidase M14, carboxypeptidase A | Molecular Function: carboxypeptidase A activity (GO:0004182), Biological Process: proteolysis and peptidolysis (GO:0006508) |
| 10 (202) | 15 (183) | 22 (209) | IPR001148: Carbonic anhydrase, eukaryotic | Molecular Function: carbonate dehydratase activity (GO:0004089), Biological Process: one-carbon compound metabolism (GO:0006730), Molecular Function: zinc ion binding (GO:0008270) |
| 10 (203) | 16 (164) | 23 (195) | IPR001173: Glycosyl transferase, family 2 | |
| 10 (204) | 16 (166) | 7 (634) | IPR001223: Glycoside hydrolase, family 18 | Molecular Function: hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553), Biological Process: carbohydrate metabolism (GO:0005975) |
| 10 (205) | 35 (55) | 81 (47) | IPR001304: C-type lectin | Molecular Function: sugar binding (GO:0005529) |
| 10 (206) | 6 (431) | 40 (110) | IPR001590: Peptidase M12B, ADAM/reprolysin | Molecular Function: metalloendopeptidase activity (GO:0004222), Biological Process: proteolysis and peptidolysis (GO:0006508) |
| 10 (207) | 14 (203) | 17 (286) | IPR001753: Enoyl-CoA hydratase/isomerase | Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152) |
| 10 (208) | 22 (107) | 13 (370) | IPR001930: Peptidase M1, membrane alanine aminopeptidase | Molecular Function: membrane alanyl aminopeptidase activity (GO:0004179), Biological Process: proteolysis and peptidolysis (GO:0006508) |
| 10 (209) | 7 (374) | 20 (240) | IPR002085: Alcohol dehydrogenase superfamily, zinc-containing | Molecular Function: zinc ion binding (GO:0008270), Molecular Function: oxidoreductase activity (GO:0016491) |
| 10 (210) | 10 (272) | 10 (470) | IPR002129: Pyridoxal-dependent decarboxylase | Biological Process: amino acid metabolism (GO:0006520), Molecular Function: carboxy-lyase activity (GO:0016831) |
| 10 (211) | 13 (215) | 17 (289) | IPR002423: Chaperonin Cpn60/TCP-1 | Molecular Function: protein binding (GO:0005515), Molecular Function: ATP binding (GO:0005524), Biological Process: cellular protein metabolism (GO:0044267) |
| 10 (212) | 13 (216) | 26 (174) | IPR002999: Tudor | Molecular Function: nucleic acid binding (GO:0003676) |
| 10 (213) | 10 (274) | 12 (395) | IPR003029: RNA binding S1 | Molecular Function: RNA binding (GO:0003723) |
| 10 (214) | 10 (277) | 23 (202) | IPR003607: Metal-dependent phosphohydrolase, HD region | Molecular Function: catalytic activity (GO:0003824) |
| 10 (215) | 10 (280) | 15 (323) | IPR004839: Aminotransferase, class I and II | Biological Process: biosynthesis (GO:0009058), Molecular Function: transferase activity, transferring nitrogenous groups (GO:0016769) |
| 10 (216) | 12 (240) | 42 (105) | IPR005135: Endonuclease/exonuclease/phosphatase | |
| 10 (217) | 11 (256) | 31 (149) | IPR006020: Phosphotyrosine interaction region | |
| 10 (218) | 29 (73) | () | IPR006625: Insect pheromone/odorant binding protein PhBP | |
| 10 (219) | 10 (284) | 22 (219) | IPR006688: ADP-ribosylation factor | Molecular Function: GTP binding (GO:0005525) |
| 9 (220) | 10 (265) | 13 (364) | IPR000555: Mov34/MPN/PAD-1 | |
| 9 (221) | 8 (320) | 10 (447) | IPR000594: UBA/THIF-type NAD/FAD binding fold | Molecular Function: catalytic activity (GO:0003824) |
| 9 (222) | 12 (227) | 21 (223) | IPR000727: Target SNARE coiled-coil region | |
| 9 (223) | 7 (363) | 32 (142) | IPR001164: Arf GTPase activating protein | Biological Process: regulation of GTPase activity (GO:0043087) |
| 9 (224) | 6 (427) | 11 (414) | IPR001258: NHL repeat | |
| 9 (225) | 11 (248) | 22 (212) | IPR001395: Aldo/keto reductase | Molecular Function: oxidoreductase activity (GO:0016491) |
| 9 (226) | 8 (327) | 32 (143) | IPR001496: SOCS protein, C-terminal | Biological Process: intracellular signaling cascade (GO:0007242) |
| 9 (227) | 16 (167) | 11 (417) | IPR001734: Na+/solute symporter | Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 9 (228) | 10 (269) | 10 (467) | IPR002007: Animal haem peroxidase | Molecular Function: peroxidase activity (GO:0004601) |
| 9 (229) | 10 (270) | 8 (577) | IPR002068: Heat shock protein Hsp20 | |
| 9 (230) | 11 (250) | 19 (255) | IPR002086: Aldehyde dehydrogenase | Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity (GO:0016491) |
| 9 (231) | 12 (233) | 3 (1246) | IPR002159: CD36 antigen | Biological Process: cell adhesion (GO:0007155), Cellular Component: membrane (GO:0016020) |
| 9 (232) | 8 (331) | 8 (578) | IPR002300: Aminoacyl-tRNA synthetase, class Ia | Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418) |
| 9 (233) | 9 (301) | 11 (420) | IPR002314: tRNA synthetase, class II (G, H, P and S) | Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: tRNA aminoacylation for protein translation (GO:0006418) |
| 9 (234) | 4 (654) | 13 (375) | IPR003616: SET-related region | |
| 9 (235) | 8 (338) | 20 (244) | IPR004012: RUN | |
| 9 (236) | 11 (254) | 10 (484) | IPR004274: NLI interacting factor | |
| 9 (237) | 10 (282) | 8 (602) | IPR005804: Fatty acid desaturase | Molecular Function: oxidoreductase activity (GO:0016491) |
| 9 (238) | 17 (150) | 21 (230) | IPR006076: FAD dependent oxidoreductase | Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491) |
| 9 (239) | 6 (472) | 14 (357) | IPR006560: AWS | |
| 9 (240) | 51 (42) | 5 (915) | IPR006578: MADF | |
| 9 (241) | 9 (310) | 26 (176) | IPR008145: Guanylate kinase/L-type calcium channel region | |
| 9 (242) | 15 (197) | 12 (401) | IPR008191: Maternal tudor protein | |
| 9 (243) | 9 (312) | 10 (494) | IPR011547: Sulphate transporter | Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: integral to membrane (GO:0016021) |
| 9 (244) | 16 (176) | 7 (693) | IPR011583: Chitinase II | Molecular Function: chitinase activity (GO:0004568), Biological Process: chitin catabolism (GO:0006032) |
| 8 (245) | 3 (726) | 6 (699) | IPR000092: Polyprenyl synthetase | Biological Process: isoprenoid biosynthesis (GO:0008299) |
| 8 (246) | 6 (413) | 24 (184) | IPR000413: Integrins alpha chain | Biological Process: cell adhesion (GO:0007155), Biological Process: cell-matrix adhesion (GO:0007160), Cellular Component: integrin complex (GO:0008305) |
| 8 (247) | 8 (317) | 29 (161) | IPR000418: Ets | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 8 (248) | 17 (147) | 15 (308) | IPR000637: HMG-I and HMG-Y, DNA-binding | |
| 8 (249) | 21 (116) | 7 (627) | IPR000718: Peptidase M13, neprilysin | Molecular Function: neprilysin activity (GO:0004245), Biological Process: proteolysis and peptidolysis (GO:0006508), Cellular Component: membrane (GO:0016020) |
| 8 (250) | 10 (268) | 15 (311) | IPR000917: Sulfatase | Biological Process: metabolism (GO:0008152), Molecular Function: sulfuric ester hydrolase activity (GO:0008484) |
| 8 (251) | 9 (296) | 10 (454) | IPR000994: Peptidase M24 | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metalloexopeptidase activity (GO:0008235) |
| 8 (252) | 11 (247) | 11 (413) | IPR001107: Band 7 protein | |
| 8 (253) | 8 (323) | 14 (341) | IPR001206: Diacylglycerol kinase, catalytic region | Molecular Function: diacylglycerol kinase activity (GO:0004143), Biological Process: protein kinase C activation (GO:0007205) |
| 8 (254) | 7 (364) | 8 (567) | IPR001208: MCM | Molecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524), Biological Process: DNA replication initiation (GO:0006270), Molecular Function: DNA-dependent ATPase activity (GO:0008094) |
| 8 (255) | 6 (425) | 8 (568) | IPR001236: Lactate/malate dehydrogenase | Biological Process: tricarboxylic acid cycle intermediate metabolism (GO:0006100), Molecular Function: oxidoreductase activity (GO:0016491) |
| 8 (256) | 15 (184) | 12 (390) | IPR001494: Importin-beta, N-terminal | Biological Process: protein-nucleus import, docking (GO:0000059), Cellular Component: nucleus (GO:0005634), Cellular Component: nuclear pore (GO:0005643), Cellular Component: cytoplasm (GO:0005737), Molecular Function: protein transporter activity (GO:0008565) |
| 8 (257) | 7 (370) | 12 (391) | IPR001529: DNA-directed RNA polymerase, M/15 kDa subunit | Molecular Function: DNA binding (GO:0003677), Molecular Function: DNA-directed RNA polymerase activity (GO:0003899), Biological Process: transcription (GO:0006350) |
| 8 (258) | 6 (436) | 20 (238) | IPR001763: Rhodanese-like | |
| 8 (259) | 6 (441) | 20 (239) | IPR002073: 3'5'-cyclic nucleotide phosphodiesterase | Molecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114), Biological Process: signal transduction (GO:0007165) |
| 8 (260) | 8 (330) | 29 (164) | IPR002165: Plexin | Molecular Function: receptor activity (GO:0004872), Cellular Component: membrane (GO:0016020) |
| 8 (261) | 4 (643) | 10 (474) | IPR002919: Protease inhibitor I8, cysteine-rich trypsin inhibitor-like | |
| 8 (262) | 5 (534) | 10 (477) | IPR003392: Patched | Molecular Function: hedgehog receptor activity (GO:0008158), Cellular Component: membrane (GO:0016020) |
| 8 (263) | 6 (456) | 6 (753) | IPR003395: SMC protein, N-terminal | Molecular Function: ATP binding (GO:0005524), Cellular Component: chromosome (GO:0005694), Biological Process: chromosome organization and biogenesis (GO:0051276) |
| 8 (264) | 7 (383) | 20 (243) | IPR003594: ATP-binding region, ATPase-like | Molecular Function: ATP binding (GO:0005524) |
| 8 (265) | 9 (305) | 14 (349) | IPR003689: Zinc/iron permease | Cellular Component: membrane (GO:0016020), Biological Process: metal ion transport (GO:0030001), Molecular Function: metal ion transporter activity (GO:0046873) |
| 8 (266) | 8 (337) | 18 (269) | IPR003903: Ubiquitin interacting motif | |
| 8 (267) | 39 (51) | 23 (203) | IPR004045: Glutathione S-transferase, N-terminal | |
| 8 (268) | 8 (344) | 18 (271) | IPR005824: KOW | |
| 8 (269) | 7 (393) | 13 (380) | IPR006055: Exonuclease | Molecular Function: exonuclease activity (GO:0004527), Cellular Component: intracellular (GO:0005622) |
| 8 (270) | 10 (283) | 11 (434) | IPR006090: Acyl-CoA dehydrogenase, C-terminal | Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491) |
| 8 (271) | 13 (219) | 15 (324) | IPR006091: Acyl-CoA dehydrogenase, central region | Molecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118) |
| 8 (272) | 6 (471) | 18 (272) | IPR006212: Furin-like repeat | |
| 8 (273) | 9 (307) | 15 (325) | IPR006553: Leucine-rich repeat, cysteine-containing subtype | |
| 8 (274) | 9 (308) | 11 (437) | IPR006575: RWD | |
| 8 (275) | 20 (129) | 1 (2460) | IPR006631: Protein of unknown function DM4/12 | |
| 8 (276) | 7 (397) | 7 (687) | IPR007863: Peptidase M16, C-terminal | |
| 8 (277) | 18 (142) | 7 (689) | IPR008753: Peptidase M13 | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237) |
| 8 (278) | 17 (155) | 9 (551) | IPR011022: Arrestin, C-terminal | |
| 7 (279) | 10 (261) | 15 (303) | IPR000033: Low-density lipoprotein receptor, YWTD repeat | Cellular Component: membrane (GO:0016020) |
| 7 (280) | 5 (485) | 7 (619) | IPR000061: SWAP/Surp | Molecular Function: RNA binding (GO:0003723), Biological Process: RNA processing (GO:0006396) |
| 7 (281) | 6 (406) | 9 (497) | IPR000089: Biotin/lipoyl attachment | |
| 7 (282) | 29 (70) | 34 (130) | IPR000215: Proteinase inhibitor I4, serpin | Molecular Function: serine-type endopeptidase inhibitor activity (GO:0004867) |
| 7 (283) | 5 (491) | 21 (222) | IPR000421: Coagulation factor 5/8 type, C-terminal | Biological Process: cell adhesion (GO:0007155) |
| 7 (284) | 8 (318) | 33 (136) | IPR000488: Death | Molecular Function: protein binding (GO:0005515), Biological Process: signal transduction (GO:0007165) |
| 7 (285) | 6 (416) | 5 (817) | IPR000640: Elongation factor G, C-terminal | Molecular Function: GTP binding (GO:0005525) |
| 7 (286) | 5 (494) | 17 (277) | IPR000644: CBS | |
| 7 (287) | 6 (417) | 12 (387) | IPR000679: Zinc finger, GATA-type | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 7 (288) | 9 (294) | 5 (821) | IPR000760: Inositol monophosphatase | Molecular Function: inositol or phosphatidylinositol phosphatase activity (GO:0004437) |
| 7 (289) | 10 (267) | 31 (148) | IPR000863: Sulfotransferase | Molecular Function: sulfotransferase activity (GO:0008146) |
| 7 (290) | 9 (295) | 6 (711) | IPR000866: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen | |
| 7 (291) | 7 (359) | 9 (509) | IPR000938: CAP-Gly | |
| 7 (292) | 6 (421) | 10 (456) | IPR001025: Bromo adjacent region | Molecular Function: DNA binding (GO:0003677) |
| 7 (293) | 5 (504) | 18 (261) | IPR001060: Cdc15/Fes/CIP4 | |
| 7 (294) | 6 (423) | 18 (262) | IPR001093: IMP dehydrogenase/GMP reductase | Molecular Function: catalytic activity (GO:0003824) |
| 7 (295) | 8 (322) | 19 (252) | IPR001179: Peptidylprolyl isomerase, FKBP-type | Biological Process: protein folding (GO:0006457) |
| 7 (296) | 6 (426) | 7 (635) | IPR001247: 3' exoribonuclease | Molecular Function: 3'-5'-exoribonuclease activity (GO:0000175), Molecular Function: RNA binding (GO:0003723), Biological Process: RNA processing (GO:0006396) |
| 7 (297) | 7 (368) | 9 (517) | IPR001375: Peptidase S9, prolyl oligopeptidase active site region | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: serine-type peptidase activity (GO:0008236) |
| 7 (298) | 9 (299) | 9 (520) | IPR001523: Paired box protein, N-terminal | Cellular Component: nucleus (GO:0005634), Biological Process: development (GO:0007275) |
| 7 (299) | 6 (433) | 13 (369) | IPR001606: AT-rich interaction region | Molecular Function: DNA binding (GO:0003677), Cellular Component: intracellular (GO:0005622) |
| 7 (300) | 7 (372) | 36 (125) | IPR001839: Transforming growth factor beta | Molecular Function: growth factor activity (GO:0008083) |
| 7 (301) | 25 (91) | 8 (575) | IPR001873: Na+ channel, amiloride-sensitive | Molecular Function: sodium channel activity (GO:0005272), Biological Process: sodium ion transport (GO:0006814), Cellular Component: membrane (GO:0016020) |
| 7 (302) | 8 (329) | 29 (163) | IPR001895: Guanine-nucleotide dissociation stimulator CDC25 | Molecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: intracellular signaling cascade (GO:0007242) |
| 7 (303) | 2 (1023) | 7 (644) | IPR001991: Sodium:dicarboxylate symporter | Biological Process: dicarboxylic acid transport (GO:0006835), Cellular Component: membrane (GO:0016020), Molecular Function: sodium:dicarboxylate symporter activity (GO:0017153) |
| 7 (304) | 7 (376) | 13 (371) | IPR002553: Adaptin, N-terminal | |
| 7 (305) | 10 (273) | 30 (157) | IPR002909: Cell surface receptor IPT/TIG | |
| 7 (306) | 7 (379) | 9 (531) | IPR003014: N/apple PAN | |
| 7 (307) | 5 (531) | 19 (256) | IPR003034: DNA-binding SAP | Molecular Function: DNA binding (GO:0003677) |
| 7 (308) | 7 (380) | 8 (588) | IPR003107: RNA-processing protein, HAT helix | Cellular Component: intracellular (GO:0005622), Biological Process: RNA processing (GO:0006396) |
| 7 (309) | 8 (335) | 15 (321) | IPR003409: MORN motif | |
| 7 (310) | 6 (457) | 23 (201) | IPR003578: Ras small GTPase, Rho type | Molecular Function: GTP binding (GO:0005525), Biological Process: small GTPase mediated signal transduction (GO:0007264) |
| 7 (311) | 6 (458) | 13 (374) | IPR003603: Leucine-rich-associated | |
| 7 (312) | 8 (339) | 10 (482) | IPR004156: Organic anion transporter polypeptide OATP | Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 7 (313) | 7 (388) | 18 (270) | IPR004160: Elongation factor Tu, C-terminal | Molecular Function: GTP binding (GO:0005525) |
| 7 (314) | 15 (191) | 1 (2329) | IPR004262: Male sterility protein | |
| 7 (315) | 7 (390) | 11 (430) | IPR004365: nucleic acid binding, OB-fold, tRNA/helicase-type | Molecular Function: nucleic acid binding (GO:0003676) |
| 7 (316) | 8 (340) | 9 (539) | IPR004837: Sodium/calcium exchanger membrane region | Cellular Component: integral to membrane (GO:0016021) |
| 7 (317) | 8 (341) | 3 (1318) | IPR005018: DOMON | Molecular Function: dopamine beta-monooxygenase activity (GO:0004500), Biological Process: catecholamine metabolism (GO:0006584) |
| 7 (318) | 21 (119) | 17 (291) | IPR005123: 2OG-Fe(II) oxygenase | |
| 7 (319) | 6 (464) | 8 (600) | IPR005475: Transketolase, central region | |
| 7 (320) | 7 (392) | 19 (258) | IPR005817: Wnt superfamily | Molecular Function: signal transducer activity (GO:0004871), Cellular Component: extracellular region (GO:0005576), Biological Process: frizzled-2 signaling pathway (GO:0007223), Biological Process: development (GO:0007275) |
| 7 (321) | 14 (207) | 7 (679) | IPR006047: Alpha amylase, catalytic region | Molecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975) |
| 7 (322) | 17 (151) | 14 (355) | IPR006186: Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase | Molecular Function: hydrolase activity (GO:0016787) |
| 7 (323) | 11 (257) | 10 (487) | IPR006569: Regulation of nuclear pre-mRNA protein | |
| 7 (324) | 8 (345) | 8 (603) | IPR006595: CTLH, C-terminal to LisH motif | |
| 7 (325) | 6 (473) | 11 (439) | IPR006612: Zinc finger, C2CH-type | Molecular Function: nucleic acid binding (GO:0003676) |
| 7 (326) | 9 (309) | 1 (2670) | IPR007889: Helix-turn-helix, Psq | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634) |
| 7 (327) | 7 (398) | 20 (246) | IPR008144: Guanylate kinase | |
| 7 (328) | 5 (566) | 15 (328) | IPR008197: Whey acidic protein, core region | |
| 7 (329) | 17 (154) | 9 (550) | IPR011021: Arrestin, N-terminal | |
| 6 (330) | 5 (486) | 10 (445) | IPR000209: Peptidase S8 and S53, subtilisin, kexin, sedolisin | Molecular Function: subtilase activity (GO:0004289), Biological Process: proteolysis and peptidolysis (GO:0006508) |
| 6 (331) | 10 (264) | 14 (331) | IPR000348: emp24/gp25L/p24 | Biological Process: intracellular protein transport (GO:0006886), Molecular Function: protein carrier activity (GO:0008320), Cellular Component: membrane (GO:0016020) |
| 6 (332) | 7 (354) | 15 (306) | IPR000425: Major intrinsic protein | Molecular Function: transporter activity (GO:0005215), Biological Process: transport (GO:0006810), Cellular Component: membrane (GO:0016020) |
| 6 (333) | 7 (356) | 7 (626) | IPR000577: Carbohydrate kinase, FGGY | Biological Process: carbohydrate metabolism (GO:0005975) |
| 6 (334) | 5 (495) | 19 (250) | IPR000651: Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal | Molecular Function: guanyl-nucleotide exchange factor activity (GO:0005085), Biological Process: small GTPase mediated signal transduction (GO:0007264) |
| 6 (335) | 11 (246) | 15 (309) | IPR000668: Peptidase C1A, papain | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: cysteine-type peptidase activity (GO:0008234) |
| 6 (336) | 14 (202) | 24 (185) | IPR000772: Ricin B lectin | |
| 6 (337) | 4 (596) | 8 (561) | IPR000850: Adenylate kinase | Molecular Function: ATP binding (GO:0005524), Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139), Molecular Function: nucleotide kinase activity (GO:0019201) |
| 6 (338) | 6 (419) | 16 (296) | IPR000904: SEC7-like | |
| 6 (339) | 4 (598) | 15 (310) | IPR000909: Phosphatidylinositol-specific phospholipase C, X region | Molecular Function: phospholipase C activity (GO:0004629), Biological Process: signal transduction (GO:0007165), Biological Process: intracellular signaling cascade (GO:0007242) |
| 6 (340) | 9 (297) | 14 (337) | IPR001012: UBX | |
| 6 (341) | 6 (420) | 6 (713) | IPR001017: Dehydrogenase, E1 component | Biological Process: metabolism (GO:0008152), Molecular Function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) |
| 6 (342) | 7 (361) | 16 (297) | IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit | Molecular Function: signal transducer activity (GO:0004871), Biological Process: G-protein coupled receptor protein signaling pathway (GO:0007186), Molecular Function: guanyl nucleotide binding (GO:0019001) |
| 6 (343) | 15 (182) | 11 (412) | IPR001023: Heat shock protein Hsp70 | Molecular Function: ATP binding (GO:0005524) |
| 6 (344) | 2 (983) | 6 (715) | IPR001087: Lipolytic enzyme, G-D-S-L | Biological Process: lipid metabolism (GO:0006629), Molecular Function: hydrolase activity, acting on ester bonds (GO:0016788) |
| 6 (345) | 8 (324) | 10 (459) | IPR001279: Beta-lactamase-like | |
| 6 (346) | 8 (325) | 8 (571) | IPR001327: FAD-dependent pyridine nucleotide-disulphide oxidoreductase | Biological Process: electron transport (GO:0006118), Molecular Function: disulfide oxidoreductase activity (GO:0015036) |
| 6 (347) | 7 (366) | 14 (344) | IPR001345: Phosphoglycerate/bisphosphoglycerate mutase | Molecular Function: catalytic activity (GO:0003824), Biological Process: metabolism (GO:0008152) |
| 6 (348) | 7 (367) | 9 (515) | IPR001373: Cullin | Biological Process: cell cycle (GO:0007049) |
| 6 (349) | 5 (507) | 9 (516) | IPR001374: Single-stranded nucleic acid binding R3H | Molecular Function: nucleic acid binding (GO:0003676) |
| 6 (350) | 6 (429) | 13 (368) | IPR001433: Oxidoreductase FAD/NAD(P)-binding | Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491) |
| 6 (351) | 5 (511) | 5 (829) | IPR001451: Bacterial transferase hexapeptide repeat | |
| 6 (352) | 4 (619) | 3 (1222) | IPR001540: Glycoside hydrolase, family 20 | Molecular Function: beta-N-acetylhexosaminidase activity (GO:0004563), Biological Process: carbohydrate metabolism (GO:0005975) |
| 6 (353) | 8 (328) | 17 (285) | IPR001699: Transcription factor, T-box | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 6 (354) | 3 (769) | 14 (346) | IPR001711: Phosphatidylinositol-specific phospholipase C, Y domain | Molecular Function: phosphoinositide phospholipase C activity (GO:0004435), Biological Process: lipid metabolism (GO:0006629), Biological Process: signal transduction (GO:0007165), Biological Process: intracellular signaling cascade (GO:0007242) |
| 6 (355) | 7 (371) | 7 (641) | IPR001737: Ribosomal RNA adenine methylase transferase | Biological Process: rRNA modification (GO:0000154), Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity (GO:0000179), Molecular Function: rRNA methyltransferase activity (GO:0008649) |
| 6 (356) | 5 (515) | 23 (198) | IPR001762: Disintegrin | |
| 6 (357) | 5 (517) | 16 (298) | IPR001846: von Willebrand factor, type D | |
| 6 (358) | 5 (518) | 15 (315) | IPR001936: Ras GTPase-activating protein | |
| 6 (359) | 2 (1026) | 3 (1240) | IPR002015: Proteasome/cyclosome, regulatory subunit | Biological Process: regulation of progression through cell cycle (GO:0000074) |
| 6 (360) | 7 (375) | 9 (526) | IPR002524: Cation efflux protein | Biological Process: cation transport (GO:0006812), Molecular Function: cation transporter activity (GO:0008324), Cellular Component: membrane (GO:0016020) |
| 6 (361) | 9 (302) | 13 (372) | IPR002659: Glycosyl transferase, family 31 | Biological Process: protein amino acid glycosylation (GO:0006486), Molecular Function: galactosyltransferase activity (GO:0008378), Cellular Component: membrane (GO:0016020) |
| 6 (362) | 6 (448) | 5 (849) | IPR002877: Ribosomal RNA methyltransferase RrmJ/FtsJ | |
| 6 (363) | 18 (140) | 7 (654) | IPR002933: Peptidase M20 | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237) |
| 6 (364) | 8 (333) | 7 (655) | IPR002937: Amine oxidase | Biological Process: electron transport (GO:0006118), Molecular Function: oxidoreductase activity (GO:0016491) |
| 6 (365) | 5 (530) | 8 (585) | IPR003000: Silent information regulator protein Sir2 | Molecular Function: DNA binding (GO:0003677), Cellular Component: chromatin silencing complex (GO:0005677), Biological Process: chromatin silencing (GO:0006342), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 6 (366) | 8 (334) | 8 (586) | IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase | Biological Process: nitrogen compound metabolism (GO:0006807), Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810) |
| 6 (367) | 6 (450) | 13 (373) | IPR003104: Actin-binding FH2 | Molecular Function: actin binding (GO:0003779), Biological Process: cell organization and biogenesis (GO:0016043) |
| 6 (368) | 6 (453) | 7 (658) | IPR003126: Zinc finger, N-recognin | Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Biological Process: ubiquitin cycle (GO:0006512) |
| 6 (369) | 6 (455) | 12 (397) | IPR003323: Ovarian tumour, otubain | |
| 6 (370) | 4 (651) | 7 (661) | IPR003405: Structural maintenance of chromosome protein SMC, C-terminal | Molecular Function: ATP binding (GO:0005524), Cellular Component: chromosome (GO:0005694), Biological Process: chromosome organization and biogenesis (GO:0051276) |
| 6 (371) | 6 (459) | 7 (665) | IPR003609: Apple-like | |
| 6 (372) | 5 (537) | 7 (666) | IPR003613: U box | Cellular Component: ubiquitin ligase complex (GO:0000151), Molecular Function: ubiquitin-protein ligase activity (GO:0004842), Biological Process: protein ubiquitination (GO:0016567) |
| 6 (373) | 12 (238) | 11 (428) | IPR003650: Orange | Molecular Function: DNA binding (GO:0003677), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 6 (374) | 10 (278) | 10 (479) | IPR003890: Initiation factor eIF-4 gamma, middle | Molecular Function: RNA binding (GO:0003723) |
| 6 (375) | 4 (656) | 14 (350) | IPR003954: RNA recognition, region 1 | Molecular Function: nucleic acid binding (GO:0003676) |
| 6 (376) | 5 (541) | 16 (300) | IPR004014: Cation transporting ATPase, N-terminal | Biological Process: cation transport (GO:0006812), Molecular Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (GO:0015662), Cellular Component: membrane (GO:0016020) |
| 6 (377) | 6 (461) | 22 (216) | IPR004038: Ribosomal protein L7Ae/L30e/S12e/Gadd45 | |
| 6 (378) | 32 (64) | 21 (229) | IPR004046: Glutathione S-transferase, C-terminal | |
| 6 (379) | 7 (387) | 10 (481) | IPR004154: Anticodon-binding | Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Biological Process: protein biosynthesis (GO:0006412) |
| 6 (380) | 6 (462) | 14 (351) | IPR004367: Cyclin, C-terminal | Biological Process: regulation of progression through cell cycle (GO:0000074), Cellular Component: nucleus (GO:0005634) |
| 6 (381) | 8 (342) | 9 (540) | IPR005024: Snf7 | Molecular Function: molecular function unknown (GO:0005554) |
| 6 (382) | 5 (553) | 5 (899) | IPR005814: Aminotransferase class-III | Molecular Function: transaminase activity (GO:0008483), Molecular Function: pyridoxal phosphate binding (GO:0030170) |
| 6 (383) | 6 (467) | 14 (354) | IPR006068: Cation transporting ATPase, C-terminal | Biological Process: cation transport (GO:0006812), Molecular Function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (GO:0015662), Cellular Component: membrane (GO:0016020) |
| 6 (384) | 6 (468) | 9 (542) | IPR006092: Acyl-CoA dehydrogenase, N-terminal | Molecular Function: acyl-CoA dehydrogenase activity (GO:0003995), Biological Process: electron transport (GO:0006118) |
| 6 (385) | 3 (857) | 5 (905) | IPR006204: GHMP kinase | Molecular Function: ATP binding (GO:0005524), Molecular Function: kinase activity (GO:0016301), Biological Process: phosphorylation (GO:0016310) |
| 6 (386) | 24 (99) | 15 (326) | IPR006620: Prolyl 4-hydroxylase, alpha subunit | Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706), Biological Process: protein metabolism (GO:0019538) |
| 6 (387) | 15 (194) | () | IPR006621: Nose resistant to fluoxetine-4, N-terminal | |
| 6 (388) | 16 (174) | 16 (301) | IPR006629: LPS-induced tumor necrosis factor alpha factor | |
| 6 (389) | 7 (396) | 13 (383) | IPR007123: Gelsolin region | |
| 6 (390) | 10 (286) | 3 (1399) | IPR007248: Mpv17/PMP22 | Cellular Component: integral to membrane (GO:0016021) |
| 6 (391) | 4 (701) | 3 (1430) | IPR008257: Peptidase M19, renal dipeptidase | Molecular Function: membrane dipeptidase activity (GO:0004237), Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: dipeptidyl-peptidase activity (GO:0008239) |
| 6 (392) | 4 (706) | 22 (220) | IPR010294: ADAM-TS Spacer 1 | Molecular Function: metalloendopeptidase activity (GO:0004222), Cellular Component: extracellular matrix (GO:0031012) |
| 6 (393) | 5 (572) | 13 (384) | IPR010569: Myotubularin-related | Molecular Function: inositol or phosphatidylinositol phosphatase activity (GO:0004437), Biological Process: phospholipid dephosphorylation (GO:0046839) |
| 6 (394) | 4 (709) | () | IPR010629: Insect allergen related | |
| 5 (395) | 8 (314) | 23 (189) | IPR000024: Frizzled CRD region | |
| 5 (396) | 4 (576) | 7 (618) | IPR000034: Laminin B | |
| 5 (397) | 6 (407) | 14 (329) | IPR000095: PAK-box/P21-Rho-binding | |
| 5 (398) | 3 (731) | 13 (363) | IPR000156: RanBP1 | |
| 5 (399) | 4 (578) | 22 (206) | IPR000164: Histone H3 | Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001) |
| 5 (400) | 6 (409) | 9 (500) | IPR000300: Inositol polyphosphate related phosphatase | Molecular Function: inositol or phosphatidylinositol phosphatase activity (GO:0004437) |
| 5 (401) | 10 (262) | 15 (305) | IPR000326: Phosphoesterase, PA-phosphatase related | |
| 5 (402) | 4 (583) | 9 (501) | IPR000331: Rap/ran-GAP | |
| 5 (403) | 5 (490) | 6 (705) | IPR000409: Beige/BEACH | |
| 5 (404) | 6 (414) | 5 (813) | IPR000435: Tektin | Biological Process: microtubule cytoskeleton organization and biogenesis (GO:0000226), Cellular Component: microtubule (GO:0005874) |
| 5 (405) | 5 (492) | 5 (814) | IPR000462: CDP-alcohol phosphatidyltransferase | Biological Process: phospholipid biosynthesis (GO:0008654) |
| 5 (406) | 2 (948) | 8 (558) | IPR000533: Tropomyosin | |
| 5 (407) | 2 (949) | 33 (137) | IPR000566: Lipocalin-related protein and Bos/Can/Equ allergen | Molecular Function: binding (GO:0005488) |
| 5 (408) | 6 (415) | 20 (235) | IPR000591: Pleckstrin/ G-protein, interacting region | Biological Process: intracellular signaling cascade (GO:0007242) |
| 5 (409) | 5 (498) | 11 (411) | IPR000697: EVH1 | |
| 5 (410) | 5 (499) | 9 (506) | IPR000756: Diacylglycerol kinase accessory region | Molecular Function: diacylglycerol kinase activity (GO:0004143), Biological Process: protein kinase C activation (GO:0007205) |
| 5 (411) | 6 (418) | 10 (450) | IPR000836: Phosphoribosyltransferase | Biological Process: nucleoside metabolism (GO:0009116) |
| 5 (412) | 4 (597) | 9 (507) | IPR000857: Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4 | Cellular Component: cytoskeleton (GO:0005856) |
| 5 (413) | 7 (358) | () | IPR000896: Arthropod hemocyanin/insect LSP | Molecular Function: oxygen transporter activity (GO:0005344), Biological Process: transport (GO:0006810) |
| 5 (414) | 4 (602) | 2 (1557) | IPR001117: Multicopper oxidase, type 1 | Molecular Function: copper ion binding (GO:0005507) |
| 5 (415) | 6 (424) | 8 (565) | IPR001132: Dwarfin protein | Cellular Component: intracellular (GO:0005622), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 5 (416) | 4 (603) | 14 (340) | IPR001180: Citron-like | Molecular Function: small GTPase regulator activity (GO:0005083) |
| 5 (417) | 4 (611) | 9 (514) | IPR001298: Filamin/ABP280 repeat | |
| 5 (418) | 4 (617) | 10 (460) | IPR001370: Proteinase inhibitor I32, inhibitor of apoptosis | Cellular Component: intracellular (GO:0005622), Biological Process: anti-apoptosis (GO:0006916) |
| 5 (419) | 5 (509) | 9 (518) | IPR001388: Synaptobrevin | Cellular Component: integral to membrane (GO:0016021), Biological Process: vesicle-mediated transport (GO:0016192) |
| 5 (420) | 4 (618) | 10 (461) | IPR001392: Clathrin adaptor complex, medium chain | Biological Process: intracellular protein transport (GO:0006886), Cellular Component: clathrin vesicle coat (GO:0030125) |
| 5 (421) | 6 (428) | 13 (367) | IPR001401: Dynamin | Molecular Function: GTPase activity (GO:0003924), Molecular Function: GTP binding (GO:0005525) |
| 5 (422) | 1 (1517) | 4 (1021) | IPR001525: C-5 cytosine-specific DNA methylase | Molecular Function: DNA binding (GO:0003677), Biological Process: DNA methylation (GO:0006306) |
| 5 (423) | 5 (513) | 7 (639) | IPR001619: Sec1-like protein | Biological Process: vesicle docking during exocytosis (GO:0006904), Biological Process: vesicle-mediated transport (GO:0016192) |
| 5 (424) | 6 (434) | 30 (155) | IPR001627: Semaphorin/CD100 antigen | |
| 5 (425) | 4 (627) | 2 (1590) | IPR001747: Lipid transport protein, N-terminal | Molecular Function: lipid transporter activity (GO:0005319), Biological Process: lipid transport (GO:0006869) |
| 5 (426) | 5 (519) | 12 (393) | IPR002083: MATH | |
| 5 (427) | 2 (1033) | 25 (181) | IPR002119: Histone H2A | Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001) |
| 5 (428) | 6 (443) | 5 (838) | IPR002125: CMP/dCMP deaminase, zinc-binding | Molecular Function: zinc ion binding (GO:0008270), Molecular Function: hydrolase activity (GO:0016787) |
| 5 (429) | 6 (444) | 7 (648) | IPR002155: Thiolase | |
| 5 (430) | 25 (92) | 17 (288) | IPR002223: Proteinase inhibitor I2, Kunitz metazoa | Molecular Function: serine-type endopeptidase inhibitor activity (GO:0004867) |
| 5 (431) | 5 (522) | 6 (739) | IPR002469: Peptidase S9B, dipeptidylpeptidase IV N-terminal | Molecular Function: dipeptidyl-peptidase IV activity (GO:0004274), Biological Process: proteolysis and peptidolysis (GO:0006508), Cellular Component: membrane (GO:0016020) |
| 5 (432) | 11 (251) | 4 (1048) | IPR002502: N-acetylmuramoyl-L-alanine amidase, family 2 | Molecular Function: N-acetylmuramoyl-L-alanine amidase activity (GO:0008745), Biological Process: peptidoglycan catabolism (GO:0009253) |
| 5 (433) | 5 (525) | 5 (844) | IPR002562: 3'-5' exonuclease | Molecular Function: nucleic acid binding (GO:0003676), Cellular Component: intracellular (GO:0005622), Molecular Function: 3'-5' exonuclease activity (GO:0008408) |
| 5 (434) | 7 (377) | 9 (527) | IPR002610: Rhomboid-like protein | |
| 5 (435) | 3 (792) | 9 (529) | IPR002857: Zinc finger, CXXC-type | Molecular Function: DNA binding (GO:0003677), Molecular Function: zinc ion binding (GO:0008270) |
| 5 (436) | 9 (304) | 9 (530) | IPR002939: Chaperone DnaJ, C-terminal | Biological Process: protein folding (GO:0006457), Molecular Function: unfolded protein binding (GO:0051082) |
| 5 (437) | 6 (451) | 15 (320) | IPR003118: Sterile alpha motif/pointed | Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634) |
| 5 (438) | 6 (452) | 19 (257) | IPR003124: Actin-binding WH2 | |
| 5 (439) | 5 (532) | 5 (857) | IPR003152: PIK-related kinase, FATC | |
| 5 (440) | 5 (533) | 8 (592) | IPR003307: eIF4-gamma/eIF5/eIF2-epsilon | Molecular Function: translation initiation factor activity (GO:0003743), Biological Process: regulation of translational initiation (GO:0006446) |
| 5 (441) | 7 (382) | 5 (863) | IPR003397: Mitochondrial import inner membrane translocase, subunit Tim17/22 | Cellular Component: mitochondrial inner membrane (GO:0005743), Molecular Function: protein transporter activity (GO:0008565), Biological Process: protein transport (GO:0015031) |
| 5 (442) | 5 (538) | 12 (398) | IPR003619: Dwarfin protein, A | Cellular Component: intracellular (GO:0005622), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 5 (443) | 4 (655) | 8 (596) | IPR003892: Ubiquitin system component Cue | |
| 5 (444) | 5 (545) | 17 (290) | IPR004182: GRAM | |
| 5 (445) | 20 (126) | () | IPR004210: BESS motif | Molecular Function: DNA binding (GO:0003677) |
| 5 (446) | 7 (389) | 12 (400) | IPR004299: Membrane bound O-acyl transferase, MBOAT | |
| 5 (447) | 5 (548) | 5 (885) | IPR004364: tRNA synthetase, class II (D, K and N) | Molecular Function: tRNA ligase activity (GO:0004812), Molecular Function: ATP binding (GO:0005524), Cellular Component: cytoplasm (GO:0005737), Biological Process: tRNA aminoacylation for protein translation (GO:0006418) |
| 5 (448) | 4 (669) | 13 (379) | IPR005112: dDENN | |
| 5 (449) | 4 (670) | 11 (432) | IPR005113: uDENN | |
| 5 (450) | () | 1 (2384) | IPR005119: LysR, substrate-binding | |
| 5 (451) | 10 (281) | () | IPR005203: Hemocyanin, C-terminal | |
| 5 (452) | 8 (343) | () | IPR005204: Hemocyanin, N-terminal | |
| 5 (453) | 2 (1181) | 5 (895) | IPR005476: Transketolase, C-terminal | |
| 5 (454) | 3 (847) | 3 (1345) | IPR005835: Nucleotidyl transferase | Biological Process: biosynthesis (GO:0009058), Molecular Function: nucleotidyltransferase activity (GO:0016779) |
| 5 (455) | 6 (466) | 11 (433) | IPR006011: Syntaxin, N-terminal | Cellular Component: membrane (GO:0016020) |
| 5 (456) | 15 (193) | 31 (150) | IPR006026: Peptidase, metallopeptidases | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: metallopeptidase activity (GO:0008237) |
| 5 (457) | 6 (469) | 4 (1104) | IPR006139: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region | Biological Process: L-serine biosynthesis (GO:0006564), Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) |
| 5 (458) | 6 (470) | 4 (1105) | IPR006140: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding | Biological Process: L-serine biosynthesis (GO:0006564), Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) |
| 5 (459) | 5 (554) | 13 (381) | IPR006153: Sodium/hydrogen exchanger | Biological Process: regulation of pH (GO:0006885), Molecular Function: solute:hydrogen antiporter activity (GO:0015299), Cellular Component: integral to membrane (GO:0016021) |
| 5 (460) | 5 (557) | 5 (912) | IPR006571: TLDc | |
| 5 (461) | 13 (220) | 5 (917) | IPR006589: Alpha amylase, catalytic subdomain | Molecular Function: alpha-amylase activity (GO:0004556), Biological Process: carbohydrate metabolism (GO:0005975) |
| 5 (462) | 7 (394) | 7 (682) | IPR006596: Nucleotide binding protein, PINc | |
| 5 (463) | 5 (559) | 6 (780) | IPR006630: RNA-binding protein Lupus La | |
| 5 (464) | 4 (691) | 10 (488) | IPR006680: Amidohydrolase | Molecular Function: hydrolase activity (GO:0016787) |
| 5 (465) | 5 (562) | 6 (786) | IPR007109: Brix | |
| 5 (466) | 6 (474) | 5 (922) | IPR007259: Spc97/Spc98 | Biological Process: microtubule cytoskeleton organization and biogenesis (GO:0000226), Cellular Component: spindle pole (GO:0000922), Cellular Component: microtubule organizing center (GO:0005815) |
| 5 (467) | 15 (195) | 9 (546) | IPR007484: Peptidase M28 | Biological Process: proteolysis and peptidolysis (GO:0006508), Molecular Function: peptidase activity (GO:0008233) |
| 5 (468) | 6 (476) | 14 (359) | IPR008211: Laminin, N-terminal | Cellular Component: extracellular matrix (sensu Metazoa) (GO:0005578) |
| 5 (469) | 3 (902) | 10 (490) | IPR008273: Cellular retinaldehyde-binding/triple function, N-terminal | |
| 5 (470) | 5 (569) | 1 (2770) | IPR008774: A2 Phospholipase | Molecular Function: phospholipase A2 activity (GO:0004623), Molecular Function: calcium ion binding (GO:0005509), Cellular Component: extracellular region (GO:0005576), Biological Process: phospholipid metabolism (GO:0006644) |
| 5 (471) | 2 (1331) | 9 (549) | IPR009886: HCaRG | |
| 5 (472) | 6 (479) | 12 (403) | IPR010625: CHCH | |
| 5 (473) | 10 (290) | 3 (1479) | IPR011611: PfkB | |
| 5 (474) | 5 (575) | 4 (1164) | IPR011706: Multicopper oxidase, type 2 | Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491) |
| 5 (475) | 4 (718) | () | IPR011707: Multicopper oxidase, type 3 | Molecular Function: copper ion binding (GO:0005507), Molecular Function: oxidoreductase activity (GO:0016491) |
| 5 (476) | 6 (482) | 6 (805) | IPR011765: Peptidase M16, N-terminal | |
| 4 (477) | 2 (930) | 18 (260) | IPR000001: Kringle | |
| 4 (478) | 5 (484) | 15 (304) | IPR000038: Cell division/GTP binding protein | Molecular Function: GTP binding (GO:0005525), Biological Process: cell cycle (GO:0007049) |
| 4 (479) | 4 (577) | 3 (1172) | IPR000040: Acute myeloid leukemia 1 protein (AML 1)/Runt | Molecular Function: DNA binding (GO:0003677), Molecular Function: ATP binding (GO:0005524), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 4 (480) | 6 (408) | 4 (974) | IPR000120: Amidase | Molecular Function: amidase activity (GO:0004040) |
| 4 (481) | 9 (291) | 20 (231) | IPR000157: TIR | Molecular Function: transmembrane receptor activity (GO:0004888), Cellular Component: membrane (GO:0016020) |
| 4 (482) | 7 (353) | 6 (701) | IPR000194: H+-transporting two-sector ATPase, alpha/beta subunit, central region | Molecular Function: ATP binding (GO:0005524), Biological Process: ATP synthesis coupled proton transport (GO:0015986), Cellular Component: proton-transporting two-sector ATPase complex (GO:0016469), Molecular Function: hydrogen-transporting ATP synthase activity, rotational mechanism (GO:0046933), Molecular Function: hydrogen-transporting ATPase activity, rotational mechanism (GO:0046961) |
| 4 (483) | 5 (487) | 3 (1177) | IPR000246: Peptidase T2, asparaginase 2 | Molecular Function: asparaginase activity (GO:0004067), Biological Process: glycoprotein catabolism (GO:0006516) |
| 4 (484) | 4 (581) | 9 (499) | IPR000261: EPS15 homology (EH) | |
| 4 (485) | 5 (488) | 11 (408) | IPR000286: Histone deacetylase superfamily | |
| 4 (486) | 4 (582) | 3 (1182) | IPR000323: Copper type II, ascorbate-dependent monooxygenase | Molecular Function: monooxygenase activity (GO:0004497), Molecular Function: copper ion binding (GO:0005507) |
| 4 (487) | 5 (489) | 16 (294) | IPR000327: POU | Molecular Function: transcription factor activity (GO:0003700), Cellular Component: nucleus (GO:0005634), Biological Process: regulation of transcription, DNA-dependent (GO:0006355) |
| 4 (488) | 3 (739) | 4 (978) | IPR000352: Class I peptide chain release factor | Molecular Function: translation release factor activity (GO:0003747), Biological Process: translational termination (GO:0006415) |
| 4 (489) | 6 (412) | 6 (704) | IPR000402: Na+/K+ ATPase, beta subunit | Molecular Function: sodium:potassium-exchanging ATPase activity (GO:0005391), Biological Process: potassium ion transport (GO:0006813), Biological Process: sodium ion transport (GO:0006814), Cellular Component: membrane (GO:0016020) |
| 4 (490) | 2 (947) | 5 (812) | IPR000432: DNA mismatch repair protein MutS, C-terminal | Molecular Function: damaged DNA binding (GO:0003684), Molecular Function: ATP binding (GO:0005524), Biological Process: mismatch repair (GO:0006298) |
| 4 (491) | 1 (1423) | 22 (207) | IPR000558: Histone H2B | Cellular Component: nucleosome (GO:0000786), Molecular Function: DNA binding (GO:0003677), Cellular Component: nucleus (GO:0005634), Biological Process: nucleosome assembly (GO:0006334), Biological Process: chromosome organization and biogenesis (sensu Eukaryota) (GO:0007001) |
| 4 (492) | 4 (588) | 4 (981) | IPR000583: Glutamine amidotransferase, class-II | Biological Process: metabolism (GO:0008152) |
| 4 (493) | 4 (590) | 12 (386) | IPR000648: Oxysterol-binding protein | Biological Process: steroid metabolism (GO:0008202) |
| 4 (494) | 4 (591) | 4 (989) | IPR000649: Initiation factor 2B related | Biological Process: cellular biosynthesis (GO:0044249) |
| 4 (495) | 7 (357) | 6 (709) | IPR000793: H+-transporting two-sector ATPase, alpha/beta subunit, C-terminal | Biological Process: ATP biosynthesis (GO:0006754), Biological Process: ATP synthesis coupled proton transport (GO:0015986), Cellular Component: proton-transporting two-sector ATPase complex (GO:0016469), Molecular Function: hydrogen-transporting ATP synthase activity, rotational mechanism (GO:0046933), Molecular Function: hydrogen-transporting ATPase activity, rotational mechanism (GO:0046961) |
| 4 (496) | 5 (500) | 3 (1195) | IPR000814: TATA-box binding | Molecular Function: DNA binding (GO:0003677), Molecular Function: RNA polymerase II transcription factor activity (GO:0003702), Cellular Component: nucleus (GO:0005634), Cellular Component: transcription factor TFIID complex (GO:0005669), Biological Process: regulation of transcription, DNA-dependent (GO:0006355), Biological Process: transcription initiation from RNA polymerase II promoter (GO:0006367) |
| 4 (497) | 2 (969) | 1 (2077) | IPR000897: GTP-binding signal recognition particle SRP54, G-domain | Molecular Function: RNA binding (GO:0003723), Molecular Function: GTP binding (GO:0005525), Cellular Component: signal recognition particle (sensu Eukaryota) (GO:0005786), Biological Process: SRP-dependent cotranslational protein-membrane targeting (GO:0006614) |
| 4 (498) | 2 (971) | 9 (508) | IPR000906: ZU5 | |
| 4 (499) | 5 (502) | 13 (365) | IPR000949: ELM2 | |
| 4 (500) | 7 (360) | () | IPR000990: Innexin | Cellular Component: gap junction (GO:0005921) |